TITLE

GPR34 as a lysophosphatidylserine receptor

AUTHOR(S)
Makide, Kumiko; Aoki, Junken
PUB. DATE
April 2013
SOURCE
Journal of Biochemistry;Apr2013, Vol. 153 Issue 4, p327
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
GPR34, a P2Y receptor family member, was identified as a candidate lysophosphatidylserine (LysoPS) receptor in 2006. However, it was controversial whether LysoPS is a real ligand for GPR34. Kitamura et al. (GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position. J. Biochem. 2012;151:511–518), using several methods for detecting activation of G protein-coupled receptor (GPCR) and chemically synthesized LysoPS analogues, concluded that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position. Furthermore, three additional GPCRs belonging to the P2Y family were recently identified as GPCRs for LysoPS, supporting the idea that GPR34 is a LysoPS receptor.
ACCESSION #
86428354

 

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