GPR34 as a lysophosphatidylserine receptor

Makide, Kumiko; Aoki, Junken
April 2013
Journal of Biochemistry;Apr2013, Vol. 153 Issue 4, p327
Academic Journal
GPR34, a P2Y receptor family member, was identified as a candidate lysophosphatidylserine (LysoPS) receptor in 2006. However, it was controversial whether LysoPS is a real ligand for GPR34. Kitamura et al. (GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position. J. Biochem. 2012;151:511–518), using several methods for detecting activation of G protein-coupled receptor (GPCR) and chemically synthesized LysoPS analogues, concluded that GPR34 is a cellular receptor for LysoPS, especially with a fatty acid at the sn-2 position. Furthermore, three additional GPCRs belonging to the P2Y family were recently identified as GPCRs for LysoPS, supporting the idea that GPR34 is a LysoPS receptor.


Related Articles

  • Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils. Manosalva, Carolina; Mena, Jaqueline; Velasquez, Zahady; Colenso, Charlotte K.; Brauchi, Sebastian; Burgos, Rafael A.; Hidalgo, Maria A. // PLoS ONE;Mar2015, Vol. 10 Issue 3, p1 

    Long chain fatty acids (LCFAs), which are ligands for the G-protein coupled receptor FFAR1 (GPR40), are increased in cow plasma after parturition, a period in which they are highly susceptible to infectious diseases. This study identified and analyzed the functional role of the FFAR1 receptor in...

  • STRUCTURE-ACTIVITY RELATIONSHIPS OF NOVEL PIPERAZINES AS ANTAGONISTS FOR THE MELANOCORTIN-4 RECEPTOR. Mahmood, Shaik; Chandra Kumar, R. Uday; Ayub, Shaik // Pharma Science Monitor;Nov2012 Supply1, Vol. 3 Issue 4, p2056 

    The melanocortin system (MC) is implicated in the regulation of a variety of physiological pathways including pigmentation, steroid function, energy homeostasis, food intake, obesity, cardiovascular, sexual function, and normal gland regulation. Comparative Molecular Field Analysis (CoMFA) and...

  • Biased signalling: the instinctive skill of the cell in the selection of appropriate signalling pathways. Ying Liu; Yang Yang; Ward, Richard; Su An; Xiao-Xi Guo; Wei Li; Tian-Rui Xu // Biochemical Journal;2015, Vol. 470 Issue 2, p155 

    GPCRs (G-protein-coupled receptors) are members of a family of proteins which are generally regarded as the largest group of therapeutic drug targets. Ligands of GPCRs do not usually activate all cellular signalling pathways linked to a particular seventransmembrane receptor in a uniform manner....

  • Allosteric and biased G protein-coupled receptor signaling regulation: potentials for new therapeutics. Khoury, Etienne; Clément, Stéphanie; Laporte, Stéphane A. // Frontiers in Endocrinology;May2014, Vol. 5, p1 

    G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that participate in many aspects of the endocrine function and are important targets for drug development. They transduce signals mainly, but not exclusively, via hetero-trimeric G proteins, leading to a diversity of...

  • High Throughput Screening (HTS) in Identification New Ligands and Drugable Targets of G Protein-Coupled Receptors (GPCRs). Dashan Wang; Yan Li; Yugao Zhang; Yuan Liu; Guixiu Shi // Combinatorial Chemistry & High Throughput Screening;Mar2012, Vol. 15 Issue 3, p232 

    G protein-coupled receptors (GPCRs) which constitute one of the largest and most versatile families of cell surface receptors are involved in a wide spectrum of physiological functions, such as, neuronal transmission, chemotaxis, pacemaker activity and embryonic development. Therefore, in the...

  • Corrigendum: Cloud-based simulations on Google Exacycle reveal ligand modulation of GPCR activation pathways. Kohlhoff, Kai J.; Shukla, Diwakar; Lawrenz, Morgan; Bowman, Gregory R.; Konerding, David E.; Belov, Dan; Altman, Russ B.; Pande, Vijay S. // Nature Chemistry;Sep2015, Vol. 7 Issue 9, p759 

    A correction to the article "cloud-based simulations on Google Exacycle reveal ligand modulation of GPCR activation pathways" that was published in the December 15, 2013 issue is presented.

  • Therapeutic role and ligands of medium- to long-chain fatty acid receptors. Takafumi Hara; Atsuhiko Ichimura; Akira Hirasawa // Frontiers in Endocrinology;Jun2014, Vol. 5, p1 

    Medium- and long-chain free fatty acids (FFAs) are energy source for whole body and biological metabolites and components. In these decades, some research groups have reported that the biological functions of medium- to long-chain FFAs are exerted through G-protein coupled receptor designated...

  • FRET-Based Detection of M1 Muscarinic Acetylcholine Receptor Activation by Orthosteric and Allosteric Agonists. Markovic, Danijela; Holdich, Jonathan; Al-Sabah, Suleiman; Mistry, Rajendra; Krasel, Cornelius; Mahaut-Smith, Martyn P.; Challiss, R. A. John // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    Background and Objective: Muscarinic acetylcholine receptors (mAChRs) are 7-transmembrane, G protein-coupled receptors that regulate a variety of physiological processes and represent potentially important targets for therapeutic intervention. mAChRs can be stimulated by full and partial...

  • Probing Heterotrimeric G Protein Activation: Applications to Biased Ligands. Denis, Colette; Saulière, Aude; Galandrin, Ségolène; Sénard, Jean-Michel; Galés, Céline // Current Pharmaceutical Design;1/11/2012, Vol. 18 Issue 2, p128 

    Cell surface G protein-coupled receptors (GPCRs) drive numerous signaling pathways involved in the regulation of a broad range of physiologic processes. Today, they represent the largest target for modern drugs development with potential application in all clinical fields. Recently, the concept...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics