TITLE

Cardiovascular and Behavioral Response to Auditory Stimuli in Boys With Fragile X Syndrome

AUTHOR(S)
Roberts, Jane E.; Long, Anna C. J.; McCary, Lindsay M.; Quady, Amy N.; Rose, Bonnie S.; Widrick, Dean; Baranek, Grace
PUB. DATE
April 2013
SOURCE
Journal of Pediatric Psychology;Apr2013, Vol. 38 Issue 3, p276
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective The aim of this study was to determine whether young boys with fragile X syndrome (FXS) exhibit abnormal physiological or behavioral responses to a moderately intense auditory stimulus, as heightened sensory reactivity is believed to contribute to problem behaviors in this population. Methods We examined the physiological basis, via heart activity, of auditory startle in young boys with FXS (n = 22) compared with typically developing controls (n = 27). Associations with mental age, behavioral reactivity, and chronological age were examined. Results Results suggest that older boys with FXS display increased cardiac reactivity to auditory input than younger boys with FXS that distinguishes them from typically developing controls. Higher mental age was associated with decreased latency to react. Conclusions Results contribute to increased understanding of the pathology in sensory processing in boys with FXS, which can inform refinement of the phenotype in young children with FXS and aid in the development of efficacious psychopharmacological and/or behavioral interventions.
ACCESSION #
86428164

 

Related Articles

  • Teaching and Behaviour Modification Strategies in Educating the Child with Fragile X Syndrome in the Classroom. Owens, Bernadette // Reach;Jan2001, Vol. 14 Issue 2, p92 

    The author describes characteristics common to many pupils with Fragile X Syndrome and suggests how curriculum, classroom management strategies and behaviour modification techniques can be tailored to meet the educational needs of these children.

  • An Investigation of Narrative Ability in Boys with Autism and Fragile X Syndrome. Hogan-Brown, Abigail L.; Losh, Molly; Martin, Gary E.; Mueffelmann, Deborah I. // American Journal on Intellectual & Developmental Disabilities;Mar2013, Vol. 118 Issue 2, p77 

    Whereas pragmatic language difficulties are characteristic of both autism and Fragile X syndrome, it is unclear whether such deficits are qualitatively similar or whether certain skills are differentially affected. This study compared narrative competence in boys with autism, Fragile X syndrome,...

  • Phonological Accuracy and Intelligibility in Connected Speech of Boys With Fragile X Syndrome or Down Syndrome. Barnes, Elizabeth; Roberts, Joanne; Long, Steven H.; Martin, Gary E.; Berni, Mary C.; Mandulak, Kerry C.; Sideris, John // Journal of Speech, Language & Hearing Research;Aug2009, Vol. 52 Issue 4, p1048 

    Purpose: To compare the phonological accuracy and speech intelligibility of boys with fragile X syndrome with autism spectrum disorder (FXS-ASD), fragile X syndrome only (FXS-O), Down syndrome (DS), and typically developing (TD) boys. Method: Participants were 32 boys with FXS-O (3-14 years), 31...

  • Clinic-Based Retrospective Analysis of Psychopharmacology for Behavior in Fragile X Syndrome. Berry-Kravis, Elizabeth; Sumis, Allison; Hervey, Crystal; Mathur, Shaguna // International Journal of Pediatrics;2012, p1 

    Fragile X syndrome (FXS) is associated with behavior that limits functioning, including distractibility, hyperactivity, impulsivity, hyperarousal, anxiety,mood dysregulation, and aggression. Medication response and side effect data were reviewed retrospectively for 257 patients (age 14 ± 11...

  • Treatment of fragile X syndrome.  // American Family Physician;6/1/94, Vol. 49 Issue 8, p1963 

    Discusses treatment options for fragile X syndrome. Prevalence of the disease; Diagnosis; Potential use of folic acid in improving behavior and intelligence of children with fragile X syndrome.

  • Early fatal course in three brothers with FG syndrome. Sorge, Giovanni; Polizzi, Agata // Clinical Pediatrics;Jul1996, Vol. 35 Issue 7, p365 

    Reports on the case of three infant brothers with FG syndrome, a relatively-rare X-linked recessive disorder. Birthweights; Results of diagnoses; Symptoms of the disease include mental retardation, severe congenital hypotonia, relative macrocephaly and characteristic facial appearance with...

  • Brief report: The association between autism and fragile X syndrome: A case report. Lenti, Carlo; Peruzzi, Cinzia // Journal of Autism & Developmental Disorders;Dec1995, Vol. 25 Issue 6, p655 

    Presents a study on the association between autism and fragile X syndrome. Case study of a child with typical autistic behavior and cerebellar hypoplasia.

  • Letters to the Editor. Fitzgerald, Michael; Rapin, Isabelle; Loddo, Silvio // Journal of Autism & Developmental Disorders;Feb2002, Vol. 32 Issue 1, p59 

    Comments on articles about autism and developmental disorders. Discussion of the molecular and cellular genetics of Fragile X syndrome; Assertion on the emotional meaning of facial experiences in people with autism.

  • A New X-linked Mental Retardation (XLMR) Syndrome With Late-onset Primary Testicular Failure, Short Stature and Microcephaly Maps to Xq25-Xq27. Cilliers, Deirdre; Parveen, R.; Clayton, P.; Cairns, S. A.; Clark, S.; Shalet, S. M.; Black, G. C. M.; Newman, W.; Clayton-Smith, J. // Journal of Medical Genetics;Sep2005, Vol. 42, pS55 

    Presents an abstract of the article "A New X-linked Mental Retardation (XLMR) Syndrome With Late-onset Primary Testicular Failure, Short Stature and Microcephaly Maps to Xq25-Xq27," by Emma Roisin Woodward, F. MacDonald, and E. R. Maher.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics