Highly sensitive cardiac troponin T and long-term mortality in a population of community-derived perimenopausal women: nested case-control study

Cramer, G. Etienne; Brouwer, Marc A.; Vader, Huib L.; de Boer, Menko Jan; Pop, Gheorghe A. M.; Pop, Victor J. M.; Verheugt, Freek W. A.
April 2013
Heart;Apr2013, Vol. 99 Issue 8, p528
Academic Journal
Objective To assess the association between baseline levels of highly sensitive cardiac troponin T (hs-cTnT) and long-term mortality in perimenopausal women of the general community using a gender specific 99th percentile reference limit. Design Nested case control. Setting The present study was conducted within the Eindhoven Perimenopausal Osteoporosis Study which is a large prospective cohort of 8503 community-derived women of the city of Eindhoven, The Netherlands. Participants Cases were defined as Eindhoven Perimenopausal Osteoporosis Study participants who provided an adequate baseline blood sample and subsequently experienced death during follow-up between 1994 and 2003. In total, 123 cases were identified. For each case two matched controls were selected using age, body mass index and hypertension as matching factors. The gender specific 99th percentile reference limit determined in the 246 controls was 8.0 ng/l. Main outcome measure All cause mortality. Results Hs-cTnT was significantly higher in the cases: 3.0 ng/l versus 2.3 ng/l ( p=0.04). After adjustment for matching and clinical risk factors, each 1 SD increase of the level of hs-cTnT was significantly associated with mortality (OR 1.3, 95% CI 1.1 to 1.7, p=0.018). With amino-terminal pro-B-type natriuretic peptide (NT-proBNP) in the multivariable model as a continuous variable the association of hs-cTnT with mortality was lost. With both hs-cTnT and NT-proBNP as dichotomous variables, the gender specific 99th percentile reference limit (8.0 ng/l) was associated with mortality, independent of NT-proBNP (OR 3.7, 95% CI 1.0 to 13.2, p=0.048). Conclusions In this study of community-derived perimenopausal women, hs-cTnT was associated with long-term mortality, independent of clinical risk factors. With the use of easily applicable cut-off levels, the gender specific reference limit of hs-cTnT had a prognostic impact that was independent of NT-proBNP.


Related Articles

  • Assessment of Awareness Regarding Osteoporosis Prevention in a Group of Pre-Menopause Women. LUPESCU, Olivera; MARCOV, Narcis // Revista de Cercetare si Interventie Sociala;Sep2016, Vol. 54, p127 

    Osteoporosis (OP) is nowadays considered one of the most important health care problems due to its frequency and due to medical and socio-economic consequences of its major complications, fragility fractures. The Global burden of OP has not been completely described yet, but the most recent data...

  • Predictors of Bone Mass in Perimenopausal Women. Slemenda, Charles W.; Hui, Siu L; Longcope, Christopher; Wellman, Henry; Johnston Jr., C. Conrad // Annals of Internal Medicine;1/15/90, Vol. 112 Issue 2, p96 

    Discusses the predictors of bone mass in perimenopausal women. Relation of bone mass to osteoporotic fracture; Value of bone mass measurements in the diagnosis of osteoporosis; Risk factors for osteoporosis.

  • Screening, treatment of osteoporosis in premenopausal women unclear. Southall, Jennifer // Endocrine Today;Oct2009, Vol. 7 Issue 12, p1 

    The article focuses on a study published in a 2009 issue of the "Journal of Women's Health" which examined secondary causes of osteoporosis in premenopausal women.

  • Risk factors and prevalence of osteoporosisin premenopausal women from pooreconomic backgrounds in Colombia. Londono, John; Valencia, Paula; Santos, Ana María; Gutiérrez, Luisa F.; Baquero, Roberto; Valle-Oñate, Rafael // International Journal of Women's Health;2013, Vol. 5, p425 

    Introduction: The prevalence of osteoporosis in premenopausal women along with associated risk factors has not been well elucidated. Recent studies have shown that poverty is a risk factor for osteoporosis. Objective: To determine the prevalence of osteoporosis and its risk factors in a group of...

  • IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women. Jian-min Liu; Hong-yan Zhao; Guang Ning; Ying Chen; Lian-zhen Zhang; Li-hao Sun; Yong-ju Zhao; Man-yin Xu; Jia-lun Chen // Journal of Bone & Mineral Metabolism;Mar2008, Vol. 26 Issue 2, p159 

    Abstract  To find out which of the following parameters—serum levels of insulin-like growth factor 1 (IGF-1), osteoprotegerin (OPG), leptin, osteocalcin (OC), and urinary excretion of N-terminal telopeptide of type I collagen (NTx), can be used as an early marker for...

  • Evaluation of biochemical and bone density parameters in premenopausal and postmenopausal women. Jada, Muni Radha; Perugu, Balananda; Chalasani, Suneetha; Parvathi, G. // International Journal of Biological & Medical Research;2013, Vol. 4 Issue 3, p3441 

    Osteoporosis is a bone disease of low bone mass and bone tissue deterioration resulting in an increased risk of fracture. The objective of this study was to analyse biochemical and bone density measurements on the dual energy X-Ray absorptiometry (DEXA) instrument among postmenopausal women in...

  • Pathological fracture: an ill telltale in osteoporosis. Üstün, Ihsan; Özçakar, Levent; Şeker, Metin; Üstün, Nilgün; Karaahmeto&gcaron;lu, Selma // Rheumatology International;May2004, Vol. 24 Issue 3, p187 

    Presents a letter to the editor describing the medical case study of 31-year ole female diagnosed with a rare combination of secondary osteoporosis with clinical complications due to pathological fractures, Graves’ disease and parathyroid adenoma citing the importance of treating the...

  • Endogenous subclinical hyperthyroidism may not lead to bone loss in premenopausal women. Saler, T; Ahbab, S; Sağlam, ZA; Keşkek, ŞŐ; Kurnaz, S // Hippokratia;2014, Vol. 18 Issue 3, p240 

    Background: Osteoporosis is defined as the decrease in bone mineral density. ?t is a serious health problem showing the predisposed person with increased bone fracture risk. Hyperthyroidism is one of the major causes of secondary osteoporosis. The aim of this study was to assess bone mineral...

  • Platelet count and MPV, routinely measured but ignored parameters used in conjunction with the diagnosis of acute coronary syndrome: single study center in Iranian population, 2010. Mirzaie, Ali Zare; Abolhasani, Maryam; Ahmadinejad, Bina; Panahi, Mahshid // Medical Journal of the Islamic Republic of Iran;Feb2012, Vol. 26 Issue 1, p17 

    Background: Myocardial infarction is the major cause of morbidity and mortality in industrialized countries. Platelet count and the mean platelet volume (MPV), a simple and reliable indicator of platelet size which correlates with platelet activation, might associate with troponin in acute chest...


Read the Article


Sign out of this library

Other Topics