Adapted exercise interventions for persons with progressive multiple sclerosis

Pilutti, Lara A.
March 2013
Applied Physiology, Nutrition & Metabolism;Mar2013, Vol. 38 Issue 3, p357
Academic Journal
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease that results in a myriad of physical and mental symptoms. Current disease-modifying therapies do not prevent long-term disability accumulation and are particularly ineffective for patients with a progressive disease onset. Exercise may represent an alternative strategy for managing symptoms and disability accumulation, particularly in progressive MS. Whereas the benefits of exercise have been established primarily in ambulatory MS patients with a relapsing disease course, few studies have investigated the benefits of exercise for patients with progressive MS with greater impairment. Therefore, the purpose of this dissertation was to determine the short-term, long-term, and maintenance effects of adapted exercise interventions for patients with progressive MS of high disability, which was addressed by conducting 2 adapted exercise interventions. The first intervention examined the effects of 24 weeks of body-weight-supported treadmill training (BWSTT) on outcomes of physical and mental functioning, fatigue, quality of life (QoL), and brain health. Outcomes were evaluated at baseline, 12 weeks, and 24 weeks following the intervention, and again 12 weeks postintervention. The second intervention evaluated and compared the effects of 12 weeks of total-body recumbent stepper training (TBRST) with BWSTT on outcomes of safety, physical and mental functioning, fatigue, QoL, and equipment preference. Safety of BWSTT and TBRST was established. Significant improvements in fatigue and QoL were observed with both training modalities; however, neither significantly improved physical function. There was some evidence to suggest that long-term BWSTT may improve cognitive performance and brain health, and that TBRST was the preferred exercise modality. Furthermore, most beneficial effects of long-term BWSTT tended not to be maintained when exercise was discontinued. This dissertation established evidence for the potential benefits of BWSTT and TBRST in patients with progressive MS with high disability. BWSTT and TBRST may represent viable alternative strategies for disease management.


Related Articles

  • Yoga for People With MS.  // IDEA Fitness Journal;Jan2015, Vol. 12 Issue 1, p71 

    The article offers information on the study conducted by the researchers from Rutgers University School of Health Related Professions in Newark, New Jersey which explores whether yoga could be used as treatment for people with multiple sclerosis (MS).

  • Will treatment make life better?  // Inside MS;Fall95, Vol. 13 Issue 3, p10 

    Discusses the necessity of balancing clinical benefits, side effects and quality of life in choosing a therapy for patients with multiple sclerosis (MS). Adaptation of cancer and AIDS quality-of-life evaluations to MS; Measurement of emotional well-being.

  • Fatigue, mood and quality of life improve in MS patients after progressive resistance training. Dalgas, U.; Stenager, E.; Jakobsen, J.; Petersen, T.; Hansen, H. J.; Knudsen, C.; Overgaard, K.; Ingemann-Hansen, T. // Multiple Sclerosis (13524585);Apr2010, Vol. 16 Issue 4, p480 

    Fatigue occurs in the majority of multiple sclerosis patients and therapeutic possibilities are few. Fatigue, mood and quality of life were studied in patients with multiple sclerosis following progressive resistance training leading to improvement of muscular strength and functional capacity....

  • Treatment experience, burden and unmet needs (TRIBUNE) in MS study: results from five European countries. Karampampa, Korinna; Gustavsson, Anders; Miltenburger, Carolin; Eckert, Benjamin // Multiple Sclerosis Journal;Jun2012 Supplement, Vol. 18 Issue 2, p7 

    Background: Multiple sclerosis (MS) is a common cause of neurological disability in young adults. The TRIBUNE study provides a detailed exploration of costs in relation to relapses and disease severity, and assesses the quality of life impact on MS patients in terms of utilities, fatigue and...

  • Symptomatic Treatment in Multiple Sclerosis. Bigi, Sandra; Yeh, E. Ann // U.S. Neurology;Fall2013, Vol. 9 Issue 1, p35 

    Multiple sclerosis (MS) is a progressive and disabling neurodegenerative disease that primarily affects young adults. Despite significant therapeutic advances in the prevention of relapses, individuals with MS experience a variety of symptoms, most notably fatigue, spasticity, depression, gait...

  • Transcranial magnetic stimulation primes the effects of exercise therapy in multiple sclerosis. Mori, Francesco; Ljoka, Concetta; Magni, Elisabetta; CodecĂ , Claudia; Kusayanagi, Hajime; Monteleone, Fabrizia; Sancesario, Andrea; Bernardi, Giorgio; Koch, Giacomo; Foti, Calogero; Centonze, Diego // Journal of Neurology;Jul2011, Vol. 258 Issue 7, p1281 

    Exercise therapy (ET) can be beneficial in disabled multiple sclerosis (MS) patients. Intermittent transcranial magnetic theta burst stimulation (iTBS) induces long-term excitability changes of the cerebral cortex and may ameliorate spasticity in MS. We investigated whether the combination of...

  • Disease-specific quality of life in multiple sclerosis: the effect of disease modifying treatment. Lily, O.; McFadden, E.; Hensor, E.; Johnson, M.; Ford, H. // Multiple Sclerosis (13524585);Dec2006, Vol. 12 Issue 6, p808 

    Disease specific quality of life was measured in the Leeds Multiple Sclerosis (MS) Treatment Programme (n = 210) using the self-report Leeds MS Quality of Life (LMSQoL) scale. The results showed a significant and sustained increase in quality of life associated with 'disease modifying'...

  • Measuring the Quality of Life in Patients with Multiple Sclerosis in Clinical Practice: A Necessary Challenge. Baumstarck, Karine; Boyer, Laurent; Boucekine, Mohamed; Michel, Pierre; Pelletier, Jean; Auquier, Pascal // Multiple Sclerosis International;2013, p1 

    While the physical disability aspect of multiple sclerosis (MS) is of great importance, quality of life (QoL) measurements are being considered increasingly important with regard to evaluating disease progression, treatment, and the management of care provided toMS patients. Despite the...

  • PATCH CUTS FATIGUE. Harrar, Sari; P.R. // Prevention;Aug2002, Vol. 54 Issue 8, p148 

    Reports on a skin patch, called the Prokarin patch, which may help relieve tiredness from multiple sclerosis (MS) without major side effects.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics