The influence of cognitive reserve on cognition in Parkinson's disease

Koerts, Janneke; Tucha, Lara; Lange, Klaus; Tucha, Oliver
April 2013
Journal of Neural Transmission;Apr2013, Vol. 120 Issue 4, p593
Academic Journal
There are considerable differences in cognition between individuals with Parkinson's Disease (PD) which might be explained by the theory of cognitive reserve. This theory states that premorbid factors, such as high intellectual capacities, provide a buffer against cognitive impairments. This study determines whether cognitive reserve influences cognition in PD. Forty-eight PD patients were included. All were assessed with two proxies of cognitive reserve, tests of cognition and both measures of disease characteristic and symptoms of depression. After accounting for age, gender, disease characteristics and depression, cognitive reserve was an independent predictor of cognitive performance. In conclusion, cognitive reserve influences cognition in PD, i.e. PD patients with a high premorbid intellectual ability show fewer cognitive impairments than patients with a low premorbid ability. This indicates that cognitive reserve needs to be taken into account when monitoring the evolution of cognition in PD, however, verification of results on a larger patient sample would be desirable.


Related Articles

  • An Evidence-Based Exercise Regimen for Patients with Mild to Moderate Parkinson's Disease. Salgado, Sanjay; Williams, Nori; Kotian, Rima; Salgado, Miran // Brain Sciences (2076-3425);Mar2013, Vol. 3 Issue 1, p87 

    Parkinson's disease (PD) is a neurological disorder that is manifested in the form of both motor and non-motor symptoms such as resting tremor, bradykinesia, muscular rigidity, depression, and cognitive impairment. PD is progressive in nature, ultimately leading to debilitating disruption of...

  • Psychiatric aspects of Parkinson's disease. Baldwin, R.C.; Byrne, E.J. // BMJ: British Medical Journal (International Edition);7/1/89, Vol. 298 Issue 6690, p3 

    Examines the psychiatric aspect of Parkinson's disease (PD). Development of dementia in PD patients; Increase susceptibility to severe depression; Occurrence of psychotic disturbance caused by antiparkinsonian drugs.

  • Neurologists' diagnostic accuracy of depression and cognitive problems in patients with parkinsonism. Bouwmans, Angela E. P.; Weber, Wim E. J. // BMC Neurology;2012, Vol. 12 Issue 1, p37 

    Background: Depression and cognitive impairment (CI) are important non-motor symptoms in Parkinson's Disease (PD) and related syndromes, but it is not clear how well they are recognised in daily practice. We have studied the diagnostic performance of experienced neurologists on the topics...

  • Cognitive symptoms in depression going 'unnoticed and untreated'.  // Practice Nurse;9/18/2015, Vol. 45 Issue 9, p10 

    The article discusses the results of a survey conducted by Depression Alliance which shows that 99% of people diagnosed with depression experienced at least one symptom of cognitive dysfunction. The most common cognitive symptoms are mentioned including difficulty with planning and organising,...

  • Determining the association of medical co-morbidity with subjective and objective cognitive performance in an inner city memory disorders clinic: a retrospective chart review. Fischer, Corinne E.; Depeng Jiang; Schweizer, Tom A. // BMC Geriatrics;2010, Vol. 10, p89 

    Background: Medical co-morbidity may be associated with impaired cognitive function based on prior studies. However, no studies to date have determined to what extent this association is linked to medical illness or other factors that may be linked to medical illness (such as education, income...

  • Perfusion ECD/SPECT in the characterization of cognitive deficits in Parkinson's disease. Antonini, A.; De Notaris, R.; Benti, R.; De Gaspari, D.; Pezzoli, G. // Neurological Sciences;Feb2001, Vol. 22 Issue 1, p45 

    Cognitive abnormalities have been reported in a large percentage of patients with Parkinson's disease (PD). Often cognitive changes are sub-clinical and involve frontal lobe function. In other occasions they develop into full dementia. Functional neuroimaging may help characterize these...

  • Rational pharmacological approaches for cognitive dysfunction and depression in Parkinson's disease. Sandoval-Rincón, Maritza; Sáenz-Farret, Michel; Miguel-Puga, Adán; Micheli, Federico; Arias-Carrión, Oscar // Frontiers in Neurology;Mar2015, Vol. 6, p1 

    Parkinson's disease (PD) is not a single entity but rather a heterogeneous neurodegenerative disorder.The present study aims to conduct a critical systematic review of the literature to describe the main pharmacological strategies to treat cognitive dysfunction and major depressive disorder in...

  • Trabzon ilinde elli beÅŸ yaşından büyüklerde depresyon ve biliÅŸsel bozulma yaygınlığı. Kavakcı, Önder; Bilici, Mustafa; Çam, Gamze; Ülgen, Metin // Anatolian Journal of Psychiatry / Anadolu Psikiyatri Dergisi;Oct2011, Vol. 12 Issue 4, p258 

    Objective: The aim of this study is to determine the prevalence of depression and cognitive impairment, in addition to investigate the relation between these disorders and sociodemographic variables in 55 years of age and older population of Trabzon city. Methods: There has been interviewed with...

  • Parkinson's disease in the elderly and the comprehensive geriatric assessment. Lauretani, Fulvio // Nigerian Medical Journal;Mar/Apr2013, Vol. 54 Issue 2, p146 

    The article presents a commentary on the prevalence of Parkinson's disease in older people. A study examined the nonmotor symptoms of PD, including depression and cognitive impairment. The course of the pathology in incidental and symptomatic cases of PD is explored. In addition, the article...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics