The pharmacology of Tourette syndrome

Thomas, Roji; Cavanna, Andrea
April 2013
Journal of Neural Transmission;Apr2013, Vol. 120 Issue 4, p689
Academic Journal
Tourette syndrome (TS) is a chronic neuropsychiatric disorder characterised by multiple motor and vocal tics, plus associated behavioural symptoms. Tics are defined as sudden, rapid, repetitive non-rhythmic movements (motor tics) or vocalisations (vocal tics). Tics are distressing symptoms and can lead to considerable disruption to social functioning and quality of life. Converging evidence from different lines of research suggests that the pathophysiology of TS involves altered dopaminergic transmission in the cortico-striatal-thalamo-cortical circuits, along with other neurotransmitter systems. Pharmacotherapy is currently the treatment of choice in patients with moderate-to-severe tics, particularly when associated with deterioration in social, occupational or academic performance. This review will focus on the recent evidence base supporting the use of different medication classes for the treatment of tics in TS. The recent publication of the European and Canadian guidelines on the management of TS are based on experts' consensus and highlight the need for randomised controlled trials, especially with regards to newly developed pharmacological agents.


Related Articles

  • Pathological glutamatergic neurotransmission in Gilles de la Tourette syndrome. Kanaan, Ahmad Seif; Gerasch, Sarah; García-García, Isabel; Lampe, Leonie; Pampel, André; Anwander, Alfred; Near, Jamie; Möller, Harald E.; Müller-Vahl, Kirsten // Brain: A Journal of Neurology;Jan2017, Vol. 140 Issue 1, p218 

    Gilles de la Tourette syndrome is a hereditary, neuropsychiatric movement disorder with reported abnormalities in the neurotransmission of dopamine and γ-aminobutyric acid (GABA). Spatially focalized alterations in excitatory, inhibitory and modulatory neurochemical ratios within specific...

  • Fine motor skills in adult Tourette patients are task-dependent. Neuner, Irene; Arrubla, Jorge; Ehlen, Corinna; Janouschek, Hildegard; Nordt, Carlos; Fimm, Bruno; Schneider, Frank; Shah, N Jon; Kawohl, Wolfram // BMC Neurology;2012, Vol. 12 Issue 1, p120 

    Background: Tourette syndrome is a neuropsychiatric disorder characterized by motor and phonic tics. Deficient motor inhibition underlying tics is one of the main hypotheses in its pathophysiology. Therefore the question arises whether this supposed deficient motor inhibition affects also...

  • SELECTIVE SOUND SENSITIVITY SYNDROME (MISOPHONIA) AND TOURETTE SYNDROME. Neal, M.; Cavanna, A. E. // Journal of Neurology, Neurosurgery & Psychiatry;Oct2012, Vol. 83 Issue 10, p7 

    Objective We present the case of a 52-year-old man first diagnosed with Tourette syndrome (TS) at the age of 44 following referral to our specialist TS clinic for chronic tic symptoms. Method On neuropsychiatric examination, he presented with multiple motor tics (including facial grimacing and...

  • Tic disorders: from pathophysiology to treatment. Rampello, Liborio; Alvano, Alessandro; Battaglia, Giuseppe; Bruno, Valeria; Raffaele, Rocco; Nicoletti, Francesco // Journal of Neurology;Jan2006, Vol. 253 Issue 1, p1 

    Tic disorders are stereotypic behaviours,more frequent than once believed, and therefore likely to be encountered by primary care physicians. Tics usually begin in childhood and are the clinical hallmark of Tourette Syndrome (TS), the most common cause of tics. TS is a relatively common...

  • Increased Thalamic Gamma Band Activity Correlates with Symptom Relief following Deep Brain Stimulation in Humans with Tourette's Syndrome. Maling, Nicholas; Hashemiyoon, Rowshanak; Foote, Kelly D.; Okun, Michael S.; Sanchez, Justin C.; Baumert, Mathias // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    Tourette syndrome (TS) is an idiopathic, childhood-onset neuropsychiatric disorder, which is marked by persistent multiple motor and phonic tics. The disorder is highly disruptive and in some cases completely debilitating. For those with severe, treatment-refractory TS, deep brain stimulation...

  • Tourette BozukluÄŸunda Ä°laç Tedavisi. Ayraler Taner, Hande; Güney, Esra; Taner, Yasemen // Current Approaches in Psychiatry / Psikiyatride Guncel Yaklasiml;2013, Vol. 5 Issue 2, p246 

    Tourette disorder is a chronic neuropsychiatric disorder characterized by vocal and motor tics. The course of the disorder shows waxing and vaning pattern and symptoms adversely affect patients' quality of life. Patients use psychopharmacologic agents for long periods to control their symptoms...

  • Altered modulation of intracortical excitability during movement preparation in Gilles de la Tourette syndrome. Heise, K.-F.; Steven, B.; Liuzzi, G.; Thomalla, G.; Jonas, M.; Müller-Vahl, K.; Sauseng, P.; Münchau, A.; Gerloff, C.; Hummel, F. C. // Brain: A Journal of Neurology;Feb2010, Vol. 133 Issue 2, p580 

    Gilles de la Tourette syndrome is a neuropsychiatric disorder in which cortical disinhibition has been proposed as a pathophysiological mechanism involved in the generation of tics. Tics are typically reduced during task performance and concentration. How this task-dependent reduction of motor...

  • Novel Surgical Therapies for Tourette Syndrome. Neimat, Joseph S.; Patil, Parag G.; Lozano, Andres M. // Journal of Child Neurology;Aug2006, Vol. 21 Issue 8, p715 

    Tourette syndrome is a common neurologic disorder with close ties to obsessive-compulsive disorder and attention-deficit hyperactivity disorder (ADHD). The majority of patients improve spontaneously as they near adulthood. Most others are effectively treated with pharmacologic agents, although...

  • Clinical Effectiveness of Quetiapine in Children and Adolescents with Tourette's Syndrome: A Retrospective Case-Note Survey. Copur, Mazlum; Arpaci, Baki; Demir, Turkay; Narin, Halis // Clinical Drug Investigation;2007, Vol. 27 Issue 2, p123 

    BACKGROUND AND OBJECTIVE: Tourette's syndrome is a relatively common biological genetic disorder with a broad spectrum of neurobehavioural manifestations. Unfortunately, treatment of the condition is often unsatisfactory and all available drugs are associated with potential adverse effects. We...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics