A revolution coming to a classic model organism

Grunwald, David Jonah
April 2013
Nature Methods;Apr2013, Vol. 10 Issue 4, p303
Academic Journal
The article focuses on the way gene replacement and gene targeting can be achieved through cleaving the genome and engineered nucleases in zebrafish. It mentions that gene targeting can be achieved in zebrafish through the insertion of small protein-coding sequences that will allow the production of endogenous proteins. It adds that the method used for the study takes the advantage of zebrafish's endogenous response to induce chromosome breaks.


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