Reproducibility restored-on toward the human interactome

Braun, Pascal
April 2013
Nature Methods;Apr2013, Vol. 10 Issue 4, p301
Academic Journal
The article discusses the two-laboratory study of the reproducibility of affinity purification-mass spectometry. M. Varjosalo and colleagues formulated a standardized process for parallel interactome analysis to attain highly reproducible data between two active laboratories. The study shows that the complexities of high-throughput protein-interaction biochemistry can be operated by standardizing experimental and bioinformatic approaches, and that interactome projects are technically feasible.


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