Proton pump inhibitors and hypomagnesemia: a rare but serious complication

Perazella, Mark A
April 2013
Kidney International;Apr2013, Vol. 83 Issue 4, p553
Academic Journal
Proton pump inhibitors (PPIs) promote hypomagnesemia through loss of active Mg2+ absorption via transient receptor potential melastatin-6 and -7 (TRPM6/7). Danziger et al. confirm the association of PPIs with hypomagnesemia in patients hospitalized at a tertiary medical center. They found that patients taking PPIs, compared with those receiving histamine-2 antagonists or no acid-suppressive medications, had a decline in serum Mg2+ after adjusting for several clinical and laboratory factors. The effect was seen only in those concomitantly receiving diuretics.


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