TITLE

Adiponectin: an enlarging role in acute kidney injury

AUTHOR(S)
Oh, Jieun; Rabb, Hamid
PUB. DATE
April 2013
SOURCE
Kidney International;Apr2013, Vol. 83 Issue 4, p546
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Adiponectin (APN) is known as an anti-inflammatory adipokine in obesity and atherosclerosis. Jin et al. examine the effects of APN deficiency in renal ischemia/reperfusion injury (IRI) using APN knockout mice and demonstrate that APN deficiency protects mice from IRI. This newly described role for APN in acute kidney injury opens up the possibility of novel mechanistic and therapeutic strategies from the cross-fertilization of the fields of obesity and kidney diseases.
ACCESSION #
86416869

 

Related Articles

  • Genetic deficiency of adiponectin protects against acute kidney injury. Jin, Xiaogao; Chen, Jiyuan; Hu, Zhaoyong; Chan, Lawrence; Wang, Yanlin // Kidney International;Apr2013, Vol. 83 Issue 4, p604 

    Adiponectin is a multifunctional cytokine that has a role in regulating inflammation. Here we determined whether adiponectin modulates ischemic acute kidney injury. Compared with wild-type mice, adiponectin-knockout mice were found to have lower serum creatinine and less tubular damage or...

  • Effects of Rosa canina L. on ischemia/ reperfusion injury in anesthetized rats. Gholampour, Firouzeh; Javadifar, Tahereh Sadat; Karimi, Saeedeh; Eslam-Zadeh, Tahereh; Owji, Seyed Mohammad // Tehran University Medical Journal;Apr2012, Vol. 70 Issue 1, p21 

    Background: Ischemia/reperfusion induced acute renal failure causes excretory functional disorders of nephrons. Ischemia/reperfusion injury is accompanied by generation of reactive oxygen species that leads to dysfunction, injury, and death of renal cells. Antioxidants of plant origin minimize...

  • Protective Action of Antioxidants on the Remote Effects of Renal Ischemia- Reperfusion Injury. Adam, Abdel Nasser Ismail; Kamel, Maher Abdel-Nabi; Rashad, Mona Mohamed; Sultan, Sherin Abdel Malak // Australian Journal of Basic & Applied Sciences;2011, Vol. 5 Issue 6, p581 

    Many studies indicate that the production of reactive oxygen species (ROS) after renal ischemia / reperfusion (I/R) may initiate a cascade of cellular injury locally and in remote organs. It has been demonstrated that preconditioning by natural antioxidants (garlic, vitamin E, Vitamin A +...

  • Remote Ischemic Conditioning for Preventing Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions/Coronary Angiography: A Meta-Analysis of Randomized Controlled Trials. Bei, Wei-jie; Duan, Chong-yang; Chen, Ji-yan; Wang, Kun; Liu, Yuan-hui; Liu, Yong; Tan, Ning // Journal of Cardiovascular Pharmacology & Therapeutics;Jan2016, Vol. 21 Issue 1, p53 

    Background: It is uncertain whether remote ischemic conditioning (RIC) has a protective effect on contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI)/coronary artery angiography (CAG). We performed a meta-analysis of randomized controlled...

  • Effect of Doxycycline on Atherosclerosis: From Bench to Bedside. Rodriguez-Granillo, Gast�n A.; Rodriguez-Granillo, Agustina; Milei, Jos� // Recent Patents on Cardiovascular Drug Discovery;Jan2011, Vol. 6 Issue 1, p42 

    Matrix metalloproteinases (MMPs) have a pivotal role in the natural history of atherosclerosis and its cardiovascular consequences. Non-selective MMP inhibition with doxycycline appears as a potential strategy to reduce the residual risk observed in patients already at intensive lipid lowering...

  • Administration of minocycline ameliorates damage in a renal ischemia/reperfusion injury model. Dan Xia; Kezhen Shen; Weide Zhong; Hao Pan // Clinical & Investigative Medicine;Apr2011, Vol. 34 Issue 2, pE55 

    Purpose: The purpose of this study was to investigate the effects of minocycline on the renal dysfunction and injury caused by bilateral ischemia/reperfusion (I/R) of murine kidneys in vito. Methods: Male C57BL/6 mice were administered minocycline (45 mg/kg i.v.) or saline (0.9%, v/v, NaCl) 36...

  • Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia–reperfusion-induced acute and chronic kidney injury. Gatti, Stefano; Bruno, Stefania; Deregibus, Maria Chiara; Sordi, Andrea; Cantaluppi, Vincenzo; Tetta, Ciro; Camussi, Giovanni // Nephrology Dialysis Transplantation;May2011, Vol. 26 Issue 5, p1474 

    Background. Several studies demonstrated that mesenchymal stem cells (MSCs) reverse acute kidney injury (AKI) by a paracrine mechanism rather than by MSC transdifferentiation. We recently demonstrated that microvesicles (MVs) released from MSCs may account for this paracrine mechanism by a...

  • The Anti-Inflammatory Effect of Erythropoietin and Melatonin on Renal Ischemia Reperfusion Injury in Male Rats. Ahmadiasl, Nasser; Banaei, Shokofeh; Alihemmati, Alireza; Baradaran, Behzad; Azimian, Ehsan // Advanced Pharmaceutical Bulletin;2014, Vol. 4 Issue 1, p49 

    Purpose: Renal ischemia reperfusion (IR) is an important cause of renal dysfunction. It contributes to the development of acute renal failure (ARF). The purpose of this study was to investigate the anti-inflammatory effect of erythropoietin (EPO) and melatonin (MEL), which are known...

  • Carbon monoxide potently prevents ischemia-induced high-mobility group box 1 translocation and release and protects against lethal renal ischemia-reperfusion injury. Ruan, Yongle; Wang, Lu; Zhao, Yue; Yao, Ying; Chen, Song; Li, Junhua; Guo, Hui; Ming, Changsheng; Chen, Shi; Gong, Feili; Chen, Gang // Kidney International;Sep2014, Vol. 86 Issue 3, p525 

    High-mobility group box 1 (HMGB1) is a chromatin-binding nuclear molecule that has potent proinflammatory effects once released by damaged cells. In some disease models, carbon monoxide (CO) exhibits anti-inflammatory and protective properties. Here, we investigated whether the protective effect...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics