TITLE

Turning the analysis of obesity-mortality associations upside down: Modeling years of life lost through conditional distributions

AUTHOR(S)
Robertson, Henry T.; Campos, Gustavo de los; Allison, David B.
PUB. DATE
February 2013
SOURCE
Obesity (19307381);Feb2013, Vol. 21 Issue 2, p398
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: We demonstrate the utility of parametric survival analysis. The analysis of longevity as a function of risk factors such as body mass index (BMI; kg/m2), activity levels, and dietary factors is a mainstay of obesity research. Modeling survival through hazard functions, relative risks, or odds of dying with methods such as Cox proportional hazards or logistic regression are the most common approaches and have many advantages. However, they also have disadvantages in terms of the ease of interpretability, especially for non-statisticians; the need for additional data to convert parameter estimates to estimates of years of life lost (YLL); debates about the appropriate time scale in the model; and an inability to estimate median survival time when the censoring rate is too high. Design and Methods: We will conduct parametric survival analyses with multiple distributions, including distributions that are known to be poor fits (Gaussian), as well as a newly discovered 'Compressed Gaussian''' distribution. Results: Parametric survival analysis models were able to accurately estimate median survival times in a population-based data set of 15,703 individuals, even for distributions that were not good fits and the censoring rate was high, due to the central limit theorem. Conclusions: Parametric survival models are able to provide more direct answers, and in our analysis of an obesity-related data set, gave consistent YLL estimates regardless of the distribution used. We recommend increased consideration of parametric survival models in chronic disease and risk factor epidemiology.
ACCESSION #
86402352

 

Related Articles

  • Are Dietary Patterns of Mothers during Pregnancy Related to Children's Weight Status? Evidence from the Lifeways Cross-Generational Cohort Study. Murrin, Celine M.; Heinen, Mirjam M.; Kelleher, Cecily C. // AIMS Public Health;2015, Vol. 2 Issue 3, p274 

    Children's diet patterns are likely to be influenced by their mothers' diet pattern. The primary objective of this study was to examine whether children's adiposity could be influenced by diet patterns of mothers during pregnancy. A secondary objective was to study the relative influence of...

  • Turning the analysis of obesity-mortality associations upside down: Modeling years of life lost through conditional distributions. Robertson, Henry T.; Campos, Gustavo de los; Allison, David B. // Obesity (19307381);Mar2013 Supplement, Vol. 21, p398 

    Objective: We demonstrate the utility of parametric survival analysis. The analysis of longevity as a function of risk factors such as body mass index (BMI; kg/m2), activity levels, and dietary factors is a mainstay of obesity research. Modeling survival through hazard functions, relative risks,...

  • Perioperative risk factors for 30-day mortality after bariatric surgery: is functional status important? Khan, Muhammad; Grinberg, Roman; Johnson, Stelin; Afthinos, John; Gibbs, Karen // Surgical Endoscopy;May2013, Vol. 27 Issue 5, p1772 

    Background: Although the mortality from bariatric surgery is low, perioperative determinants of morbidity and mortality in the bariatric surgery population to date have not been fully defined. This study aimed to evaluate the factors capable of predicting perioperative mortality based on...

  • Associations of body mass index and gestational weight gain with term pregnancy outcomes in urban Cameroon: a retrospective cohort study in a tertiary hospital. Fouelifack, Florent Ymele; Fouedjio, Jeanne Hortence; Fouogue, Jovanny Tsuala; Sando, Zacharie; Fouelifa, Loic Dongmo; Mbu, Robinson Enow // BMC Research Notes;12/19/2015, Vol. 8, p1 

    Background: Obesity is a rising public health issue worldwide. Guidelines regarding maternal body mass index (BMI) and gestational weight gain (GWG) are missing in Cameroon where maternal mortality rate remains very high. We hypothesized that obesity and inappropriate GWG are associated with...

  • RESEARCH Open Access Prevalence of overweight, obesity and thinness in 9-10 year old children in Mauritius. Caleyachetty, Rishi; Rudnicka, Alicja R.; Echouffo-Tcheugui, Justin B.; Siegel, Karen R.; Richards, Nigel; Whincup, Peter H. // Globalization & Health;2012, Vol. 8 Issue 1, p28 

    Objective: To document the prevalence of overweight, obesity and thinness in 9-10 year old children in Mauritius.Methods: 412 boys and 429 girls aged 9-10 years from 23 primary schools were selected using stratified cluster random sampling. All data was cross-sectional and collected via...

  • Hypertension, a Neglected Disease in Rural and Urban Areas in Moramanga, Madagascar. Ratovoson, Rila; Rasetarinera, Ony Rabarisoa; Andrianantenaina, Ionimalala; Rogier, Christophe; Piola, Patrice; Pacaud, Pierre // PLoS ONE;9/10/2015, Vol. 10 Issue 9, p1 

    Background: Hypertension is one of the main risk factors of cardiovascular diseases. In Madagascar, studies on hypertension in urban and rural communities are scarce. Objectives: The aim of this study was to determine the prevalence of hypertension and identify associated risk factors in...

  • Interacting effects of obesity, race, ethnicity and sex on the incidence and control of adult-onset asthma. Koebnick, Corinna; Fischer, Heidi; Daley, Matthew F.; Ferrara, Assiamira; Horberg, Michael A.; Waitzfelder, Beth; Young, Deborah Rohm; Gould, Michael K. // Allergy, Asthma & Clinical Immunology;10/19/2016, Vol. 12, p1 

    Background: To improve care and control for patients with adult-onset asthma, a better understanding of determinants of their risk and outcomes is important. We investigated how associations between asthma, asthma control and obesity may be modified by patient demographic characteristics....

  • Obesity and Its Relationship with Hypertension among Adults 50 Years and Older in Jinan, China. Wang, Shu-Kang; Ma, Wei; Wang, Shumei; Yi, Xiang-Ren; Jia, Hong-Ying; Xue, Fuzhong // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Background: The relationship between obesity and hypertension varies with geographical area, race and definitions of obesity. Our study aimed to investigate the prevalence of obesity using standard Chinese criteria based on the body mass index (BMI) and the waist circumference (WC) and to...

  • Predictors of chronic breathlessness: a large population study. Bowden, Jacqueline A.; To, Timothy H. M.; Abernethy, Amy P.; Currow, David C. // BMC Public Health;2011, Vol. 11 Issue 1, p33 

    Background: Breathlessness causes significant burden in our community but the underlying socio-demographic and lifestyle factors that may influence it are not well quantified. This study aims to define these predictors of chronic breathlessness at a population level. Methods: Data were collected...

Share

Other Topics