TITLE

StuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion

AUTHOR(S)
Jahaninejad, Tahere; Ghasemi, Nasrin; Kalantar, Seyyed; Sheikhha, Mohammad; Pashaiefar, Hossein
PUB. DATE
March 2013
SOURCE
Journal of Assisted Reproduction & Genetics;Mar2013, Vol. 30 Issue 3, p437
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: This is a case- control study to determine whether G1733A polymorphism of androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA). Method: A total of 85 women with at least two recurrent spontaneous abortion before 20th week of gestation composed the study group. Subjects were genotyped by the polymerase chain reaction restriction fragment length polymorphism method. Results: The observed frequencies of GG, GA and AA genotypes of the G1733A polymorphism were 5.89 %, 82.35 % and 11.76 %, respectively, for the patient group and 71.76 %, 23.51 % and 4.71 %, respectively, for the control group. Allele frequencies of the G1733A polymorphism among patients and controls were 0.47 and 0.84, respectively, for the dominant allele (G) (wild type) and 0.53 and 0.16, respectively, for the A allele (mutant type). Conclusions: These results indicated that the androgen receptor G1733A polymorphism is strongly associated with increased risk for RSA.
ACCESSION #
86304971

 

Related Articles

  • Association of interleukin-10 gene promoter polymorphism in spontaneous abortions: a family-based triad study. Vidyadhari, M.; Sujatha, M.; Krupa, P.; Jyothy, A.; Nallari, Pratibha; Venkateshwari, A. // Inflammation Research;Dec2015, Vol. 64 Issue 12, p963 

    Objective: The present study is a triad study designed to determine the co-relation of IL-10 −819C/T promoter polymorphism with the risk of spontaneous abortions. Materials: A total of 50 families with spontaneous abortions and 60 families with medically terminated pregnancies were...

  • Association of CYP1A1, GSTM1, and GSTT1 gene polymorphism with risk of oral submucous fibrosis in a section of North Indian population. Ghosh, Tanima; Gupta, Shalini; Bajpai, Prachi; Agarwal, Deepti; Agarwal, Mohit; Gupta, O.; Agrawal, Deepa // Molecular Biology Reports;Oct2012, Vol. 39 Issue 10, p9383 

    Genetic alterations in the genes expressing drug metabolizing enzymes can make an individual susceptible to various cancers. This study detects the polymorphisms at CYP1A1, GSTM1, and GSTT1 genes in a section of North Indian population and determines the susceptibility to oral submucous fibrosis...

  • A preliminary case study of androgen receptor gene polymorphism association with impulsivity in women with alcoholism. Mettman, Daniel J.; Butler, Merlin G.; Poje, Albert B.; Penick, Elizabeth C.; Manzardo, Ann M . // Advances in Genomics & Genetics;2014, Vol. 4, p5 

    Objective: The androgen receptor (AR) gene, located on the X chromosome, contains a common polymorphism involving cytosine-adenine-guanine (CAG) repeats, which impacts disease and could contribute to the unequal sex ratio in alcoholism. CAG repeats in the AR gene are known to correlate with...

  • The role of IL6 and ESR1 gene polymorphisms as immunological factors of pregnancy maintenance. Kucherenko, A. M.; Vorobiova, I. I.; Rudakova, N. V.; Livshits, L. A. // Biopolymers & Cell;2013, Vol. 29 Issue 5, p402 

    Aim. The study is aimed at the evaluation of the association of IL6 gene -174G/C polymorphism and ESR1 gene -397C/T polymorphism with recurrent pregnancy loss (RPL) pathogenesis and at the investigation of the ESR1 gene -397C/T variant regulatory significance for the IL6 gene function. Methods....

  • Investigation on estrogen receptor alpha gene polymorphisms in Iranian women with recurrent pregnancy loss. Mahdavipour, Marzieh; Idali, Farah; Zarei, Saeed; Talebi, Saeed; Fatemi, Ramina; Jeddi-Tehrani, Mahmood; Pahlavan, Somayeh; Rajaei, Farzad // Iranian Journal of Reproductive Medicine;Jun2014, Vol. 12 Issue 6, p395 

    Background: Recurrent pregnancy loss (RPL) is a multifactorial disorder. Environmental factors and genetics can affect pregnancy outcomes. Objective: Conflicting data suggest an association between estrogen receptor alpha (ESR1) gene polymorphisms and RPL. In this study, such association was...

  • No evidence of the human chorionic gonadotropin-beta gene 5 βV79M polymorphism in Mexican women. Pablo Dominguez-Lopez; Laura Diaz-Cueto; Alfredo Ulloa-Aguirre; Miguel Lopez-Valle; Fabian Arechavaleta-Velasco // Endocrine (1355008X);Dec2008, Vol. 34 Issue 1-3, p117 

    Abstract  Human chorionic gonadotropin (hCG) is a placental hormone essential for the maintenance of pregnancy. Previous studies have shown a G to A transition in exon 3 of the hCGβ gene 5, which changes the naturally occurring valine to methionine in codon 79. The frequency of this...

  • Relationship between cytokine gene polymorphisms and recurrent spontaneous abortion. Ru-Xin Liu; Ying Wang; Li-Hua Wen // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 6, p9786 

    Recurrent spontaneous abortion (RSA), defined as three or more sequential abortions before the twentieth week of gestation. Some studies have led to the awareness that immunological factors play an important role in establishing a successful pregnancy. The aim of present study was to investigate...

  • Evaluation of transcobalamin II rs1801198 and transcobalamin II receptor rs2336573 gene polymorphisms in recurrent spontaneous abortion. Hashemi, Mohammad; Mokhtari, Mojgan; Yazdani-Shahrbabaki, Vajiheh; Danesh, Hiva; Bizhani, Fatemeh; Taheri, Mohsen // Journal of Obstetrics & Gynaecology;Aug2018, Vol. 38 Issue 6, p860 

    It has been proposed that transcobalamin 2 (TCN2) and the transcobalamin 2 receptor (TCN2R) are associated with idiopathic recurrent spontaneous abortion (RSA). The aim of the present study was to investigate the impact of TCN2 rs1801198 and TCN2R rs2336573 polymorphism on RSA in a sample of...

  • Placental Expression of CD100, CD72 and CD45 Is Dysregulated in Human Miscarriage. Lorenzi, Teresa; Turi, Angelo; Lorenzi, Maria; Paolinelli, Francesca; Mancioli, Francesca; Sala, Lucia La; Morroni, Manrico; Ciarmela, Pasquapina; Mantovani, Angelo; Tranquilli, Andrea Luigi; Castellucci, Mario; Marzioni, Daniela // PLoS ONE;May2012, Vol. 7 Issue 5, p1 

    Context and Objective: The etiology of miscarriage is often multifactorial. One major cause, immunological rejection of the fetus, has not been clearly elucidated. Our aim was to establish whether the semaphorin CD100, its natural receptor CD72, and the glycoprotein CD45, implicated in immune...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics