TITLE

FREE RADICAL SCAVENGING AND ANTIOXIDANT POTENTIAL OF THESPESIA POPULNEA (L.) FLOWER EXTRACT

AUTHOR(S)
PATIL, P.S.; VENKATNARAYANAN, R.D.; ARGADE, P.D.; SHINDE, P.R.
PUB. DATE
April 2012
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Apr2012 Supplement 3, Vol. 4, p561
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Antioxidants are act as scavengers and play the housekeeper's role by mopping up free radicals before they possibly will get a chance to create havoc in a body. Thus they may well be defined as the substances that are capable of quenching or stabilizing free radicals. Thespesia populnea widely distributed throughout the India mostly found in Coast forests and evergreen forest of Western Ghats, largely grown as a roadside tree in tropical regions. Objective: To evaluate the antioxidant potential of flower of Thespesia populnea; yet unreported. Material and Method: Antioxidant potential of methanolic extract of flower (TPF) was evaluated by in- vitro antioxidant studies like free radical scavenging activity by DPPH method, nitric oxide method, anti- lipid peroxidation study, and reducing power assay and expressed as % scavenging and IC50. Ascorbic acid was served as standard for the study. Result: The phytochemical screening of the extract mainly revealed the presence of terpenoids and flavonoids mainly; whereas the HPTLC profile of extract confirmed the presence of β- sitosterol in the extract. The extract showed the significant antioxidant activity as compared to control; but comparatively less than the ascorbic acid. The antioxidant potential was increased in dose dependant manner. Conclusion: From the present study it can be conclude that TPF exhibits better antioxidant activity due to prominent presence of vital bioactive constituents.
ACCESSION #
86242868

Tags: FREE radical scavengers;  FREE radicals (Chemistry);  FREE radical reactions;  FLOWERS -- Therapeutic use;  PLANT extracts -- Therapeutic use;  MEDICINAL plants -- Therapeutic use

 

Related Articles

  • Synthesis, antimicrobial and antioxidant activities of 5-((2-oxo-2 H-chromen-7-yloxy)methyl)-1,3,4-thiadiazol-2(3 H)-one derived from umbelliferone. Al-Amiery, Ahmed; Al-Temimi, Ali; Sulaiman, Ghassan; Aday, Hamdan; Kadhum, Abdul; Mohamad, Abu // Chemistry of Natural Compounds;Jan2013, Vol. 48 Issue 6, p950 

    5-((2-Oxo-2 H-chromen-7-yloxy)methyl)-1,3,4-thiadiazol-2(3 H)-one was synthesized and characterized by FT-IR and NMR spectra in addition to elemental analysis. The prepared compound shows considerable antibacterial and antifungal activity. The free radical scavenging activity of the synthesized...

  • Protective Action of Flavonoids Genistein and Gingerol against Cisplatin Toxicity In Vitro. Beg, T.; Siddique, Y. H.; Afzal, M. // Journal of Young Pharmacists;2012, Vol. 4 Issue 2, p124 

    The article presents a study which looks into the toxicity potential of a platinum-based chemotherapy drug called cisplatin in in vitro in human lymphocytes. The study has discovered that a combination of cisplatin and free radical scavenging agents such as genistein and gingerol during...

  • In vitro antioxidant potential of stem bark of Prosopis cineraria Linn. Velmurugan, V.; Arunachalam, G.; Ravichandiran, V. // Journal of Pharmacy Research;Feb2013, Vol. 6 Issue 2, p140 

    The present study was to design and evaluation of antioxidants activity of methanolic extract of Prosopis cineraria (Linn.). Anti-oxidants can neutralize the side effects of free radicals by scavenging or chain breaking (like vitamin A, C, -carotene, etc.) or some other mechanism of action....

  • Evaluation of phenolic contents and antioxidant activity of various solvent extracts of Sonchus asper (L.) Hill.  // Chemistry Central Journal;2012, Vol. 6 Issue 1, p12 

    The article presents information on a study which investigates the use of nonpolar (hexane, SAHE; ethyl acetate, SAEE and chloroform, SACE) and polar (methanol, SAME) crude extracts of the whole plant sonchus asper (SA) for treating various ailments associated with liver, lungs and kidneys. The...

  • Evaluation of Natural Substances' Protective Effects Against Oxidative Stress in a Newly Developed Canine Endothelial Cell-Based Assay and in Cell-Free Radical Scavenging Assays. Ripoll, Christophe; Coussaert, Aur�lie; Waldenberger, Ferdinand Rudolf; Vischer, Claudia; Ginouv�s, Amandine; McGahie, David; Gatto, Hugues // International Journal of Applied Research in Veterinary Medicine;2012, Vol. 10 Issue 2, p113 

    Oxidative stress has been shown to induce damage in a variety of canine and human cardiovascular cell types, and is implicated in the initiation and progression of various cardiac diseases. Various antioxidant agents used in the management of heart failure appear to confer cardio-protective...

  • P055 - EVALUATION OF THE DPPH RADICAL SCAVENGING ACTIVITY, TOTAL PHENOLIC COMPOUND AMOUNT AND MINERAL CONTENT OF FRUITS GRAPE BOÄžAZKERE.  // Turkish Journal of Biochemistry / Turk Biyokimya Dergisi;2012 Special Issue, Vol. 37 Issue S1, p196 

    The human body has several antioxidant defense systems to protect healthy cell membranes from free radicals. The innate defense systems may be supported by antioxidative compounds taken as foods, cosmetics and medicine. Therefore, the antioxidative compounds provided by the diet may enrich the...

  • ANTIOXIDANT ACTIVITIES AND PHYTOCHEMICALS OF EDIBLE FLOWERS. Sawatpipat, Jeerawat; Phunsawat, Vatin; Rojsanga, Piyanuch; Sithisarn, Pongtip // Thai Journal of Pharmaceutical Sciences;2014 Supplement, Vol. 38, p26 

    The article presents a study that investigates the phytochemicals and antioxidant activities of edible flowers in Bangkok, Thailand. Researchers did an experiment to screen and to identify the free radicals and scavenging activities of extracts of 11 edible flowers with the use of 1,1-...

  • IN VITRO ASSESSMENT OF TINOSPORA CORDIFOLIA STEM FOR ITS ANTIOXIDANT, FREE RADICAL SCAVENGING AND DNA PROTECTIVE POTENTIALS. NIKHIL BABAN GHATE; DIPANKAR CHAUDHURI; NRIPENDRANATH MANDAL // International Journal of Pharma & Bio Sciences;Jan-Mar2013, Vol. 4 Issue 1, pP-373 

    Antioxidants have reactive oxygen species (ROS) scavenging ability with great relevance in the prevention of oxidative stress. The present study aimed to examine the antioxidant and ROS scavenging activities of 70% methanolic extract of Tinospora cordifolia. The plant was found a significant...

  • Radical!  // Joe Weider's Muscle & Fitness;Dec94, Vol. 55 Issue 12, p36 

    Notes the impact of free radicals on aging and certain diseases. Definition of free radicals; Body mechanism against free radicals; Functions of antioxidant chemicals to keep free radicals in check; Health risks of excessive free radicals.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics