TITLE

Application of Gas Chromatography/Mass Spectrometry to Therapeutic Monitoring of Valproic Acid

AUTHOR(S)
Abaimov, D.; Sariev, A.; Tyurin, I.; Prokhorov, D.; Noskova, T.; Shvedkov, V.; Seifulla, R.
PUB. DATE
February 2013
SOURCE
Pharmaceutical Chemistry Journal;Feb2013, Vol. 46 Issue 11, p679
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A new method for quantitative determination of the anticonvulsant valproic acid that was based on gas chromatography with mass spectrometric detection of three characteristic ionized fragments with m/ z = 73, 102, and 115 was developed. The proposed technique was used to solve tasks of therapeutic anticonvulsant drug monitoring and applied to the determination of individual pharmacokinetic characteristics of valproic acid in patients at the Research Center of Neurology of the Russian Academy of Medical Sciences.
ACCESSION #
86177347

 

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