An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet

Rengan, Anil K.; Agarwal, Ashok; van der Linde, Michelle; du Plessis, Stefan S.
January 2012
Reproductive Biology & Endocrinology;2012, Vol. 10 Issue 1, p92
Academic Journal
Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may transpire. The cytoplasmic droplet then becomes known as excess residual cytoplasm, which can impair overall sperm function and produce higher levels of reactive oxygen species, potentially leading to male infertility. Though the distinction between cytoplasmic droplets and excess residual cytoplasm has been made, some studies fail to recognize the difference and incorrectly label the latter as a cytoplasmic droplet. This review attempts to clarify excess residual cytoplasm's effect on fertility, examine the enzymes responsible, and suggest tests and possible treatment options for those affected by this defect.


Related Articles

  • 37° C is Optimum Temperature for Collection, Transportation, and Processing.  // Fertility Weekly;1/20/2003, p8 

    Presents a study in Ohio on the optimum temperature for collection, transportation and processing of human spermatozoa. Evaluation of sperm motility; Result of increased production of reactive oxygen species; Ranges of temperature for incubating semen samples from infertile men.

  • EFFECT OF VARIOUS BIOMOLECULES FOR NORMAL FUNCTIONING OF HUMAN SPERM FOR FERTILIZATION: A REVIEW. Vickram, A. S.; Ramesh Pathy, M.; Sridharan, T. B. // International Journal of Pharmacy & Pharmaceutical Sciences;Oct-Dec2012, Vol. 4 Issue 4, p18 

    Semen is a mixture of sperm and secretions of seminal vesicle, prostate gland and Cowper's gland. The molecules present in the semen includes Sperm, amino acids, proteins, lipids, Anti-sperm antibodies and trace elements like include zinc, megnesium, sodium and potasium. Each of these molecules...

  • Reactive oxygen species measurement in neat and washed semen: comparative analysis and its significance in male infertility assessment. Venkatesh, S.; Shamsi, M.; Dudeja, S.; Kumar, R.; Dada, Rima // Archives of Gynecology & Obstetrics;Jan2011, Vol. 283 Issue 1, p121 

    Purpose: Oxidative stress (OS) is a major concern in idiopathic male infertility as elevated levels of reactive oxygen species (ROS) in the semen is believed to adversely affect sperm functional competence and damage both nuclear and mitochondrial DNA. Therefore, identifying infertile men with...

  • Gene deletions in an infertile man with sperm fibrous sheath dysplasia. M. Estenoz; P. Piomboni // Human Reproduction;Oct2005, Vol. 20 Issue 10, p2790 

    BACKGROUND: Asthenozoospermia may sometimes be related to genetic structural defects of the sperm tail detectable by transmission electron microscopy. Dysplasia of the fibrous sheath (DFS) is a genetic sperm defect, characterized by dysplastic development of the axonemal and periaxonemal...

  • Increased frequency of X-bearing sperm in males from an infertility clinic: analysis by two-color fluorescence in situ hybridization. Johannisson; Leuschner; Hüppe; Hinrichs; Al-Hasani; Diedrich; Schwinger; Mennicke // Cytogenetic & Genome Research;2002, Vol. 98 Issue 4, p240 

    Semen samples from 34 men visiting the Lübeck infertility clinic were investigated using a two-color FISH method to determine the ratio of X- and Y-bearing sperm. The overall ratio was significantly shifted to a preponderance of X-containing sperm. A statistical comparison with seven reports...

  • Comparison of reactive oxygen species in neat and washed semen of infertile men. Moein, Mohammad Reza; Vahidi, Serajedin; Ghasemzadeh, Jalal; Tabibnejad, Nasirn // Iranian Journal of Reproductive Medicine;May2014, Vol. 12 Issue 5, p301 

    Background: Male are involved in near 50% of cases of infertility and reactive oxygen species (ROS) playing an important role in decreasing fertility potential. Accurate measurement of ROS seems to be important in evaluation of infertile male patients. Objective: To compare ROS measurement in...

  • Deficiency of alpha-Tocopherol in Seminal Fluid as a Probable Factor in Low Fertility in Côte d'Ivoire. Diafouka, François; Gbassi, Gildas K. // African Journal of Reproductive Health;Sep2009, Vol. 13 Issue 3, p123 

    To evaluate the level of alpha-Tocopherol in seminal fluid of patients with low fertility, forty subjects with low fertility (17 with asthenospermia and 32 with oligoasthenospermia) and 21 subjects with normal sperm parameters were recruited into this study for assessing their alpha-Tocopherol...

  • Correlación entre el número de colonias bacterianas en espermocultivos con las alteraciones en los índices del análisis seminal. Terriquez-Fimbres, María de los Ángeles; González-Barrios, Juan Antonio // Boletin del Colegio Mexicano de Urologia;jul-sep2003, Vol. 18 Issue 3, p100 

    The seminal liquid infection disease has been consider a powerful condition to alter the seminal parameters like motility and viability in the spermatozoa, the main microorganism found in seminal culture is a Chlamydia trachomatis and Ureaplasma urealyticum, in this work we determine the...

  • Cigarette Smoking and the Risk of Male Infertility. Colagar, A. Hosseinzadeh; Jorsaraee, G. A.; Marzony, E. Tahmasbpour // Pakistan Journal of Biological Sciences;2007, Vol. 10 Issue 21, p3870 

    In this research we investigated the effect of cigarette smoking on sperm parameters both before and after swim-up. Semen sample provided from fertile smoker (n = 25), fertile nonsmoker (n = 21), infertile smoker (n = 23) and infertile nonsmoker men (n = 32). Semen analysis was performed...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics