TITLE

Interim PET/CT-based prognostic model for the treatment of diffuse large B cell lymphoma in the post-rituximab era

AUTHOR(S)
Yang, Deok-Hwan; Ahn, Jae-Sook; Byun, Byung; Min, Jung; Kweon, Sun-Seog; Chae, Yee; Sohn, Sang; Lee, Sang; Kim, Hae; Jung, Sung-Hoon; Kim, Yeo-Kyeoung; Kim, Hyeoung-Joon; Bom, Hee-Seung; Lee, Je-Jung
PUB. DATE
April 2013
SOURCE
Annals of Hematology;Apr2013, Vol. 92 Issue 4, p471
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The prognostic accuracy of interim F-fluoro-2-dexoy- d-glucose positron emission tomography/computerized tomography (PET/CT) using three different methods of response assessments during rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy was investigated in 186 patients with newly diagnosed diffuse large B cell lymphoma (DLBCL). The response of interim PET/CT was assessed based on a combined evaluation of the Deauville five-point scale (5-PS), the rates of reduction in the maximal standardized uptake value (ΔSUVmax), and the rates of reduction in the metabolic tumor volume (ΔMTV2.5). Positivity on the 5-PS, the optimal cutoff of ΔSUVmax, or the optimal cutoff of ΔMTV2.5 could each predict disease progression. Over a median follow-up of 22.8 months, the assessment of responses based on the 5-PS, ΔSUVmax, and ΔMTV2.5 had prognostic value for progression-free survival. When patients were allocated a score of 0 to 3 depending on the presence of an inadequate response by visual, ΔSUVmax, or ΔMTV2.5, the outcomes of patients with a score of 0 were significantly superior to those with a score of 1, 2, or 3. The interim PET/CT response based on visual, SUV-based, and MTV-based assessment had significant negative predictive value for disease progression and a high potential for predicting outcomes of patients with DLBCL.
ACCESSION #
85923229

 

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