Increased expression of forkhead box M1 protein is associated with poor prognosis in clear cell renal cell carcinoma

Wu, Xiao-Rong; Chen, Yong-Hui; Liu, Dong-Ming; Sha, Jian-Jun; Xuan, Han-Qing; Bo, Juan-Jie; Huang, Yi-Ran
March 2013
Medical Oncology;Mar2013, Vol. 30 Issue 1, p1
Academic Journal
Forkhead box protein M1 (FoxM1) is crucial in the regulation of various biological processes, including cell proliferation, organogenesis, and angiogenesis. Overexpression of FoxM1 is associated with carcinogenesis. In this study, immunohistochemistry was carried out to examine FoxM1 expression in clear cell renal cell carcinoma (ccRCC), and these data were examined for correlation with clinicopathological parameters and prognosis. FoxM1 protein had high expression in 37 of 87 cases of ccRCC (42.5 %), which was significantly higher than in normal tissues, and FoxM1 overexpression was significantly associated with tumor stage ( P = 0.005) and recurrence ( P = 0.027). The Kaplan-Meier survival analysis demonstrated that FoxM1 expression was significantly associated with shorter recurrence-free survival and overall survival ( P = 0.007 and P = 0.008, respectively). Multivariate analysis further demonstrated that FoxM1 was an independent prognostic factor for patients with ccRCC. So FoxM1 might be a potential molecular marker to predict the prognosis of patients with ccRCC.


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