TITLE

Prognostic significance of BRCA1 expression in gastric cancer

AUTHOR(S)
Chen, Wenjiao; Wang, Jian; Li, Xiao; Li, Jingying; Zhou, Li; Qiu, Tianzhu; Zhang, Meiling; Liu, Ping
PUB. DATE
March 2013
SOURCE
Medical Oncology;Mar2013, Vol. 30 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The breast and ovarian cancer susceptibility gene 1 (BRCA1) is a well-known tumor suppressor gene implicated in the predisposition of early-onset breast and ovarian cancer. The aim of this study is to identify the prognostic significance of BRCA1 in patients with gastric cancer undergoing surgery and platinum-based adjuvant chemotherapy. BRCA1 protein expression profiles were evaluated by immunohistochemistry (IHC) on surgical specimens of 637 gastric cancer patients. The relationships between BRCA1 expression and existing prognostic factors, platinum-based adjuvant chemotherapy, disease-free survival, and overall survival were analyzed. There were 637 stage II/III patients, of which 219 samples (34 %) were evaluated as BRCA1 IHC positive. BRCA1 expression had statistically significant association only with tumor differentiation ( p = 0.004). The patients with BRCA1-positive expression had significantly prolonged overall survival ( p = 0.049). The patients received platinum-based adjuvant chemotherapy showed a better prognosis ( p = 0.017). The patients with BRCA1-negative expression benefited more from platinum-based adjuvant chemotherapy ( p = 0.024). Multivariate analysis demonstrated that tumor size, T category, N category, vascular or nerves invasion, and platinum-based adjuvant chemotherapy were good prognostic factors for overall survival ( p < 0.05). BRCA1 expression was not significantly related to overall survival ( p = 0.127). The positive correlation between BRCA1 expression and overall survival suggests that patients with BRCA1 expression have a better prognosis in gastric cancer. Patients without BRCA1 expression can benefit from platinum-based adjuvant chemotherapy. However, BRCA1 expression might not be a good prognostic factor.
ACCESSION #
85859824

 

Related Articles

  • Clinicopathological and prognostic significance of Ki-67, caspase-3 and p53 expression in gastric carcinomas. LI-JUN XIAO; SHUANG ZHAO; EN-HONG ZHAO; XIN ZHENG; WEN-FENG GOU; YASUO TAKANO; HUA-CHUAN ZHENG // Oncology Letters;2013, Vol. 6 Issue 5, p1277 

    The understanding of proliferative and apoptotic changes has aided the improvement of the diagnosis, treatment and prevention of gastric cancer. The present study aimed to investigate the clinicopathological and prognostic significance of Ki-67, caspase-3 and p53 in gastric cancer. The...

  • Low expression of RBMS3 and SFRP1 are associated with poor prognosis in patients with gastric cancer. Tao Zhang; Youliang Wu; Zheng Fang; Qiang Yan; Shangxin Zhang; Ruochuan Sun; Junaid khaliq; Yongxiang Li // American Journal of Cancer Research;2016, Vol. 6 Issue 11, p2679 

    RNA binding motif, single stranded interacting protein 3 (RBMS3) has been reported as a tumor suppressor gene (TSG) in some squamous carcinoma. However, its expression levels and clinical significance in gastric cancer (GC) remains unclear. Secreted frizzled-related protein 1 (SFRP1) plays a...

  • Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer. Kim, Jin; Cho, Hyun; Kim, Miso; Lee, Kyung-Hun; Kim, Min; Han, Sae-Won; Oh, Do-Youn; Lee, Hyuk-Joon; Im, Seock-Ah; Kim, Tae-You; Yang, Han-Kwang; Kim, Woo; Bang, Yung-Jue // Cancer Chemotherapy & Pharmacology;Jun2013, Vol. 71 Issue 6, p1435 

    Background: We aimed to investigate the role of BRCA1 nuclear expression in sporadic gastric cancer; currently, the role remains unknown. Methods: Patients with gastric cancer who received curative operation with D2 dissection were enrolled in this study. Adjuvant chemotherapy was administered...

  • SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma. Hedner, Charlotta; Gaber, Alexander; Korkocic, Dejan; Nodin, Björn; Uhlén, Mathias; Kuteeva, Eugenia; Johannesson, Henrik; Jirström, Karin; Eberhard, Jakob // Virchows Archiv;Dec2014, Vol. 465 Issue 6, p649 

    Gastric cancer is the second most common cause of cancer-related death worldwide, and the incidence of esophageal adenocarcinoma is rising. While some progress has been made in treatment strategies, overall survival remains very poor for patients with adenocarcinoma in the upper gastrointestinal...

  • Gastric Sarcomatoid Carcinoma. Carboni, Fabio; Levi Sandri, Giovanni; Valle, Mario; Covello, Renato; Garofalo, Alfredo // Journal of Gastrointestinal Surgery;Nov2013, Vol. 17 Issue 11, p2025 

    Sarcomatoid carcinoma is an uncommon biphasic malignant tumor of the stomach. The histogenesis remains unknown, and a definitive diagnosis is obtained with immunohistochemical staining. Since prognosis is poor after surgery, more effective diagnostic tools are needed in order to select the...

  • NDRG1 expression is related to the progression and prognosis of gastric cancer patients through modulating proliferation, invasion and cell cycle of gastric cancer cells. Chang, Xiaojing; Xu, Xiaoyang; Ma, Jinguo; Xue, Xiaoying; Li, Zhenhua; Deng, Peng; Zhang, Shuanglong; Zhi, Yu; Chen, Jing; Dai, Dongqiu // Molecular Biology Reports;Sep2014, Vol. 41 Issue 9, p6215 

    N-myc downstream-regulated gene 1 (NDRG1) has been proposed as a tumor suppressor gene in many different types of tumors, but its potential function and corresponding mechanism are not yet fully elucidated. This study aims to detect the possible function of NDRG1 in gastric cancer progression....

  • Clinicopathological significance of LRP16 protein in 336 gastric carcinoma patients. Ya-Zhuo Li; Po Zhao; Wei-Dong Han; Costello, Eithne // World Journal of Gastroenterology;10/14/2009, Vol. 15 Issue 38, p4833 

    AIM: To investigate the expression of leukemia related protein 16 (LRP16), and the possible relationship between LRP16 expression and clinicopathological indices in 336 gastric carcinoma patients. METHODS: Immunohistochemistry was used to detect LRP16 expression in 336 cases of paraffin-embedded...

  • Polymorphism of DNA Methyltransferase 3b and Association with Development and Prognosis in Gastric Cancer. Wang, Chuan; Jia, Zhifang; Cao, Donghui; You, Lili; Jin, Meishan; Wu, Xing; Wen, Simin; Cao, Xueyuan; Jiang, Jing // PLoS ONE;8/11/2015, Vol. 10 Issue 8, p1 

    Objective: DNA methyltransferase 3b (DNMT3b) plays an important role in abnormal methylation during tumorigenesis. Polymorphism of the DNMT3b gene may influence DNMT3b activity and be associated with cancer risk. This study aimed to investigate the association between single nucleotide...

  • Decreased xanthine oxidoreductase is a predictor of poor prognosis in early-stage gastric cancer. N Linder // Journal of Clinical Pathology;Sep2006, Vol. 59 Issue 9, p965 

    BACKGROUND: Xanthine oxidoreductase (XOR) is a key enzyme in the degradation of DNA, RNA and high-energy phosphates. About half of the patients with breast cancer have a decrease in XOR expression. Patients with breast cancer with unfavourable prognosis are independently identified by the loss...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics