TITLE

Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein

AUTHOR(S)
Jakobsen, Martin R; Mogensen, Trine H; Paludan, Søren R
PUB. DATE
March 2013
SOURCE
Cell Research;Mar2013, Vol. 23 Issue 3, p320
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Human immunodeficiency virus type 1 (HIV-1) is the cause of AIDS. In recent years it has emerged that cellular interferon-stimulated genes (ISG), play important roles in cell-intrinsic restriction of HIV replication. A publication now describes a novel strategy employed by HIV-infected cells to restrict viral replication, which involves inhibition of viral mRNA translation by the ISG Schlafen 11.
ACCESSION #
85846395

 

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