TITLE

RON is not a prognostic marker for resectable pancreatic cancer

AUTHOR(S)
Tactacan, Carole M.; Chang, David K.; Cowley, Mark J.; Humphrey, Emily S.; Wu, Jianmin; Gill, Anthony J.; Chou, Angela; Nones, Katia; Grimmond, Sean M.; Sutherland, Robert L.; Biankin, Andrew V.; Daly, Roger J.
PUB. DATE
January 2012
SOURCE
BMC Cancer;2012, Vol. 12 Issue 1, p395
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown. Methods: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed. Results: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study. Conclusions: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.
ACCESSION #
85787851

 

Related Articles

  • Assessing the role of the EGF receptor in the development and progression of pancreatic cancer. Cook, Natalie; Frese, Kristopher K.; Moore, Malcolm // Gastrointestinal Cancer: Targets & Therapy;2014, Vol. 4, p23 

    The prognosis for patients with pancreatic cancer remains poor despite increased knowledge of its molecular genetics and histopathological progression. Pancreatic cancer is a complicated, heterogeneous tumor with several common genetic alterations. Aberrant epidermal growth factor receptor...

  • Ribosomal Protein S6 Kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein. Qi Ma; Sunny Guin; Padhye, Snehal S.; Yong-Qing Zhou; Rui-Wen Zhang; Ming-Hai Wang // Molecular Cancer;2011, Vol. 10 Issue 1, p66 

    Background: Epithelial to mesenchymal transition (EMT) occurs during cancer cell invasion and malignant metastasis. Features of EMT include spindle-like cell morphology, loss of epithelial cellular markers and gain of mesenchymal phenotype. Activation of the RON receptor tyrosine kinase by...

  • Decreased TUSC3 Promotes Pancreatic Cancer Proliferation, Invasion and Metastasis. Fan, Xiaoqiang; Zhang, Xiu; Shen, Jie; Zhao, Haibin; Yu, Xuetao; Chen, Yong’an; Zhuang, Zhuonan; Deng, Xiaolong; Feng, Hua; Wang, Yunfei; Peng, Long // PLoS ONE;2/12/2016, Vol. 11 Issue 2, p1 

    Pancreatic cancer is an aggressive disease with dismal prognosis. It is of paramount importance to understand the underlying etiological mechanisms and identify novel, consistent, and easy-to-apply prognostic factors for precision therapy. TUSC3 (tumor suppressor candidate 3) was identified as a...

  • CUX1 mediates tumour cell survival: implications for future therapies? Malek, Nisar P. // Gut;Aug2010, Vol. 59 Issue 8, p1014 

    The author comments on the study "Pancreas: CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer," by S. Ripka and colleagues, published within the issue. A brief information on adenocarcinoma of the pancreas, along with the failure of several drug...

  • Effects of the Natural Isoflavonoid Genistein on Growth, Signaling Pathways and Gene Expression of Matrix Macromolecules by Breast Cancer Cells. Kousidou, O. Ch.; Tzanakakis, G. N.; Karamanos, N. K. // Mini Reviews in Medicinal Chemistry;Mar2006, Vol. 6 Issue 3, p331 

    Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17�- estradiol and exerts antiestrogenic effects. It also affects the signal transduction components Akt, FAK, ErbB-2 and Bcl-2. Key enzymes implicated in cancer invasion are also affected by...

  • Membrane proteins: the key players of a cancer cell. Kampen, Kim; Kampen, Kim R // Journal of Membrane Biology;Jul2011, Vol. 242 Issue 2, p69 

    Membrane proteins are involved in the prognosis of the most common forms of cancer. Membrane proteins are the hallmark of a cancer cell. The overexpressed membrane receptors are becoming increasingly important in cancer cell therapy. Current renewing therapy approaches based on receptor...

  • EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Cortina, Carme; Palomo-Ponce, Sergio; Iglesias, Mar; Fernández-Masip, Juan Luis; Vivancos, Ana; Whissell, Gavin; Humà, Mireia; Peiró, Nerea; Gallego, Lourdes; Jonkheer, Suzanne; Davy, Alice; Lloreta, Josep; Sancho, Elena; Batlle, Eduard // Nature Genetics;Nov2007, Vol. 39 Issue 11, p1376 

    The genes encoding tyrosine kinase receptors EphB2 and EphB3 are β-catenin and Tcf4 target genes in colorectal cancer (CRC) and in normal intestinal cells. In the intestinal epithelium, EphB signaling controls the positioning of cell types along the crypt-villus axis. In CRC, EphB activity...

  • Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma. Carrasco-García, Estefanía; Saceda, Miguel; Martínez-Lacaci, Isabel // Cells (2073-4409);Jun2014, Vol. 3 Issue 2, p199 

    Glioblastoma multiforme is the most frequent, aggressive and fatal type of brain tumor. Glioblastomas are characterized by their infiltrating nature, high proliferation rate and resistance to chemotherapy and radiation. Recently, oncologic therapy experienced a rapid evolution towards "targeted...

  • Neuropilins: A New Target for Cancer Therapy. Grandclement, Camille; Borg, Christophe // Cancers;2011, Vol. 3 Issue 2, p1899 

    Recent investigations highlighted strong similarities between neural crest migration during embryogenesis and metastatic processes. Indeed, some families of axon guidance molecules were also reported to participate in cancer invasion: plexins/semaphorins/neuropilins, ephrins/Eph receptors,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics