TITLE

Robust, synergistic regulation of human gene expression using TALE activators

AUTHOR(S)
Maeder, Morgan L; Linder, Samantha J; Reyon, Deepak; Angstman, James F; Fu, Yanfang; Sander, Jeffry D; Joung, J Keith
PUB. DATE
March 2013
SOURCE
Nature Methods;Mar2013, Vol. 10 Issue 3, p243
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Artificial activators designed using transcription activator-like effector (TALE) technology have broad utility, but previous studies suggest that these monomeric proteins often exhibit low activities. Here we demonstrate that TALE activators can robustly function individually or in synergistic combinations to increase expression of endogenous human genes over wide dynamic ranges. These findings will encourage applications of TALE activators for research and therapy, and guide design of monomeric TALE-based fusion proteins.
ACCESSION #
85776244

 

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