MicroRNA-107 inhibits glioma cell migration and invasion by modulating Notch2 expression

Chen, Lei; Chen, Xiang-Rong; Zhang, Run; Li, Peng; Liu, Yi; Yan, Ke; Jiang, Xiao-Dan
April 2013
Journal of Neuro-Oncology;Apr2013, Vol. 112 Issue 1, p59
Academic Journal
MicroRNAs (miRNAs), small non-protein-coding RNA molecules, modulate target gene expression by binding to 3′untranslated regions (UTR) of target mRNA. These molecules are aberrantly expressed in many human cancers, and can function either as tumor suppressors or oncogenes. In the current study, we show that miR-107 is down-regulated in glioma tissues and cell lines, and its overexpression leads to inhibition of the migratory and invasive ability of glioma cells via direct targeting of Notch2, which is known to transactivate Tenascin-C and Cox-2. Experiments with Notch2 siRNA further suggest that miR-107 may exerts its anti-invasive activity through Notch2 signaling pathways. Our findings collectively indicate that miR-107 is involved in glioma cell migration and invasion, and support its utility as a potential target for glioma treatment.


Related Articles

  • Anti-PABPC1 Co-Immunoprecipitation for Examining the miRNAs Directly Targeting the 3′-UTR of EED mRNA. Hu, Yi; Yin, Kun-Lun; Ma, Xu; Xia, Hong-Fei // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate post-transcriptional gene expression by base pairing with partially complementary sequences within target messenger RNAs (mRNAs). Although the target genes and the precise biological functions of individual miRNAs remain largely...

  • MicroRNA-181 inhibits glioma cell proliferation by targeting cyclin B1. FEI WANG; JI-YONG SUN; YOU-HOU ZHU; NING-TAO LIU; YI-FANG WU; FEI YU // Molecular Medicine Reports;2014, Vol. 10 Issue 4, p2160 

    Small non-coding RNAs from the microRNA family (miRs) are important elements in the posttranscriptional control of gene expression. miRs are known to regulate numerous cellular processes and are of crucial importance during development and in pathological conditions, including tumor initiation...

  • MicroRNA-650 expression in glioma is associated with prognosis of patients. Sun, Boqian; Pu, Bo; Chu, Dake; Chu, Xiaodan; Li, Wei; Wei, Dun // Journal of Neuro-Oncology;Dec2013, Vol. 115 Issue 3, p375 

    MicroRNAs are known as non-coding RNAs that regulate the expression of target mRNA. Accumulating evidence has indicated that microRNA expression in human malignancies can be utilized as a prognostic marker for patients. However, the prognostic value of miR-650 in human glioma has not been...

  • MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status. Yang, Guang; Zhang, Ruyou; Chen, Xiaofeng; Mu, Yulong; Ai, Jing; Shi, Chen; Liu, Yaohua; Shi, Changbin; Sun, Lihua; Rainov, Nikolai; Li, Hulun; Yang, Baofeng; Zhao, Shiguang // Journal of Molecular Medicine;Oct2011, Vol. 89 Issue 10, p1037 

    MicroRNAs are single-stranded small non-coding RNA molecules which regulate mammalian cell growth, differentiation, and apoptosis by altering the expression of other genes and play a role in tumor genesis and progression. MiR-106a is upregulated in several types of malignancies and provides a...

  • MicroRNA Profiling in the Malignant Progression of Gliomas. Stupak, E. V.; Veryaskina, Yu. A.; Titov, S. E.; Achmerova, L. G.; Stupak, V. V.; Ivanov, M. K.; Zhimulev, I. F.; Kolesnikov, N. N. // AIP Conference Proceedings;2016, Vol. 1760 Issue 1, p1 

    Wealth of data indicates that microRNAs (miRNAs) are directly involved in carcinogenesis and that miRNA can, on their own, act as diagnostic and prognostic markers for various types of cancers, including gliomas. The aim of this study was to conduct a comparative analysis of expression profile...

  • Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas. Kwak, H-J; Kim, Y-J; Chun, K-R; Woo, Y M; Park, S-J; Jeong, J-A; Jo, S H; Kim, T H; Min, H S; Chae, J S; Choi, E-J; Kim, G; Shin, S-H; Gwak, H-S; Kim, S-K; Hong, E-K; Lee, G-K; Choi, K-H; Kim, J H; Yoo, H // Oncogene;5/26/2011, Vol. 30 Issue 21, p2433 

    Gliomas are associated with high mortality because of their exceedingly invasive character. As these tumors acquire their invasiveness from low-grade tumors, it is very important to understand the detailed molecular mechanisms of invasion onset. Recent evidences suggest the significant role of...

  • MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major Infection. Lemaire, Julien; Mkannez, Ghada; Guerfali, Fatma Z.; Gustin, Cindy; Attia, Hanène; Sghaier, Rabiaa M.; Dellagi, Koussay; Laouini, Dhafer; Renard, Patricia // PLoS Neglected Tropical Diseases;Oct2013, Vol. 7 Issue 10, p1 

    Background: Leishmania (L.) are intracellular protozoan parasites able to survive and replicate in the hostile phagolysosomal environment of infected macrophages. They cause leishmaniasis, a heterogeneous group of worldwide-distributed affections, representing a paradigm of neglected diseases...

  • Long non-coding RNA SNHG15 promotes CDK14 expression via miR-486 to accelerate non-small cell lung cancer cells progression and metastasis. Jin, Bing; Jin, Hua; Wu, Hai-Bo; Xu, Jian-Jun; Li, Bing // Journal of Cellular Physiology;Sep2018, Vol. 233 Issue 9, p7164 

    Long non-coding RNAs (lncRNAs) have been validated to play important role in multiple cancers, including non-small cell lung cancer (NSCLC). In present study, our team investigate the biologic role of SNHG15 in the NSCLC tumorigenesis. LncRNA SNHG15 was significantly upregulated in NSCLC tissue...

  • Down-Regulation of miR-140 Induces EMT and Promotes Invasion by Targeting Slug in Esophageal Cancer. Li, Weiling; Jiang, Guojun; Zhou, Jianping; Wang, Hongmin; Gong, Zegang; Zhang, Zheng; Min, Ke; Zhu, Hongdi; Tan, Yongfei // Cellular Physiology & Biochemistry (Karger AG);Nov2014, Vol. 34 Issue 5, p1466 

    Background/Aims: MicroRNAs (miRNAs) are reported to regulate cell invasion and functions by interfering with the translation of target mRNAs, but the role of miRNAs in esophageal cancer (EC) remains unclear. Methods: RT-PCR and Western blot were used to detect the expression of miRNAs and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics