TITLE

ANTIHYPERGLYCEMIC EFFECT OF SOPHORAINTERRUPTA BEDD. ANDGYMNOSPORIAEMARGINATA (WILLD.) IN ALLOXAN INDUCED DIABETIC RATS

AUTHOR(S)
HEMAMALINI, K.; PAVANI, P.
PUB. DATE
January 2013
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Jan-Mar2013, Vol. 5 Issue 1, p103
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The antihyperglycemic effect of SophorainterruptaBedd.(Family: Leguminosae) and Gymnosporiaemarginata(Willd). (Family: Celastraceae) methanolic extracts of leaves were investigated in Alloxan induced diabetic albino rats. A comparison was made between both the plant extracts and a known antidiabetic drug Glibenclamide (5 mg/kg body weight). The dried leaves of Sophorainterrupta and Gymnosporiaemarginata were subjected to extraction by continuous hot percolation using methanol as solvent and were subjected to standardization using pharmacognostical and phytochemical screening. Dose selection was made on the basis of acute oral toxicity study (4000mg/kg b. wt.) as per OECD and CPCSEA guidelines. Oral administration of extracts of Sophorainterrupta (400mg/kg) and Gymnosporiaemarginata (300mg/kg) for 7 days resulted in a significant reduction in blood glucose levels. Alloxan induced hyperglycemicrat model was used for the evaluation of antihyperglycemic effect. Activity is more for Sophorainterruptain comparision with Gymnosporiaemarginata. Sophorainterrupta methanolic extract (SIME) and Gymnosporiaemarginata methanolic extract (GEME) showed significant (p<0.001) antihyperglycemic effect. The blood glucose levels of these plant extracts on seventh day of the study were SIME (111.2±6.16) GEME (131.5±3.23) in comparision of diabetic control (414.2±5.03). In glucose loaded rats, SIME exhibited glucose level of (126.8 ± 3.945) after 30 min and (89.83±1.167) after 90 min, whereas the levels in GEME treated animals were (123.5±2.997) after 30 min and (88.67±2.044) after 90 min.These extracts also prevented body weight loss in diabetic rats. The drug has the potential to act as an antidiabetic drug.
ACCESSION #
85723659

 

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