TITLE

Blackwater fever like in murine malaria

AUTHOR(S)
Rivera, Norma; Romero, Samanta; Menchaca, Ángeles; Zepeda, Armando; García, Luis; Salas, Gerardo; Romero, Laura; Malagón, Filiberto
PUB. DATE
March 2013
SOURCE
Parasitology Research;Mar2013, Vol. 112 Issue 3, p1021
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Blackwater fever (BWF) is the term used to designate the occurrence of hemoglobin pigments in the urine of patients infected with malaria parasites. BWF is more often associated with Plasmodium falciparum infection in man. The pathogenesis of BWF has not been explained satisfactorily. In the present study, the clinical and pathological observations made upon CD1 mice infected with Plasmodium yoelii yoelii lethal strain with clinical signs of hemoglobinuria and acute renal failure were evaluated. From the 40 P. yoelii yoelii-infected mice, 14 presented hemoglobinuria. In the observations, it was emphasized that hemoglobinuria occurred in the animals 1-2 days before they die. At 6 days post-infection, infected hemoglobinuric mice (HM) exhibited clinical signs such as dark red urine, apnea, and evident oliguria and hematuria; urine microscopical examination showed very few red blood cells. The entire non hemoglobinuric infected mice had a high parasitemia preceding the time of death, while the HM parasitemia was just detectable. In HM, marked hepatosplenomegaly, anemia, and renal and hepatic dysfunction were observed with the blood chemistry analysis at 6 days post-infection. Severe renal lesions were demonstrated in histopathological and scanning electron microscopy samples. Occlusion and necrosis of convoluted tubules were the main lesions found. The conditions required for the experimental production of hemoglobinuria in CD1 mouse infected by P. yoelii yoelii is still unknown. The clinical picture of a BWF, like in our rodents, was produced exclusively by the interaction between the parasite and its host. Results showed that hemoglobinuria in CD1 mice infected with P. yoelii yoelii and BWF in man infected with P. falciparum are similar in their pathogenesis.
ACCESSION #
85716133

 

Related Articles

  • Blackwater fever caused by Plasmodium vivax infection in the acquired immune deficiency syndrome. Katongole-Mbidde, Edward; Banura, Cecil; Kizito, Alexandria // British Medical Journal (Clinical Research Edition);3/19/1988, Vol. 296 Issue 6625, p827 

    Focuses on the blackwater fever caused by Plasmodium vivax infection in patients with AIDS in east Africa. Symptoms of blackwater fever; Incidence of severe parasitic invasion at the time of hemolysis; Diagnosis of blackwater fever.

  • Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum. Tonkin, Christopher J.; Carret, Céline K.; Duraisingh, Manoj T.; Voss, Till S.; Ralph, Stuart A.; Hommel, Mirja; Duffy, Michael F.; da Silva, Liliana Mancio; Scherf, Artur; Ivens, Alasdair; Speed, Terence P.; Beeson, James G.; Cowman, Alan F. // PLoS Biology;Apr2009, Vol. 7 Issue 4, p0771 

    Cytoadherance of Plasmodium falciparum-infected erythrocytes in the brain, organs and peripheral microvasculature is linked to morbidity and mortality associated with severe malaria. Parasite-derived P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) molecules displayed on the erythrocyte...

  • Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. Bodi, Joseph M.; Nsibu, Célestin N.; Longenge, Roland L.; Aloni, Michel N.; Akilimali, Pierre Z.; Tshibassu, Pierre M.; Kayembe, Patrick K.; Omar, Ahmeddin H.; Hirayama, Kenji; Verhaegen, Jan // Malaria Journal;2013, Vol. 12 Issue 1, p1 

    Background: Blackwater fever (BWF) is one of the severe forms of malaria. This complication was first described among non-immune European expatriates in the malaria endemic areas. Recently, resurgence of this form of malaria has been reported among the indigenous populations. The objective of...

  • Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. Lon, Chanthap; Michele Spring; Sok, Somethy; Chann, Soklyda; Bun, Rathvichet; Mali Ittiverakul; Nillawan Buathong; Thay, Khengheng; Kong, Nareth; You, Yom; Worachet Kuntawunginn; Lanteri, Charlotte A.; Saunders, David L. // Malaria Journal;2014, Vol. 13 Issue 1, p1 

    The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine,...

  • Dihydroartemisinin/piperaquine.  // Reactions Weekly;Nov2014, Vol. 1525 Issue 1, p51 

    An abstract of the article "Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine," by C. Lon and colleagues is presented.

  • Parenteral artesunate reduced inhospital mortality more than quinine in severe falciparum malaria. Dondorp, A.; Nosten K., F.; Stepniewska // Evidence Based Medicine;Apr2006, Vol. 11 Issue 2, p52 

    The article focuses on the results of a study on the relative effectiveness of parenteral artesunate and parenteral quinine for patients with severe falciparum malaria. According to the results, the artesunate group had a lower risk of mortality and of developing hypoglycemia than the quinine...

  • Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia. Maude, Richard J.; Silamut, Kamolrat; Plewes, Katherine; Charunwatthana, Prakaykaew; Ho, May; Abul Faiz, M.; Rahman, Ridwanur; Hossain, Md Amir; Hassan, Mahtab U.; Bin Yunus, Emran; Hoque, Gofranul; Islam, Faridul; Ghose, Aniruddha; Hanson, Josh; Schlatter, Joel; Lacey, Rachel; Eastaugh, Alison; Tarning, Joel; Lee, Sue J.; White, Nicholas J. // Journal of Infectious Diseases;Jan2014, Vol. 209 Issue 1, p120 

    Background. Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in...

  • Reduced erythrocyte deformability associated with hypoargininemia during Plasmodium falciparum malaria. Rey, Juliana; Buffet, Pierre A.; Ciceron, Liliane; Milon, Geneviève; Mercereau-Puijalon, Odile; Safeukui, Innocent // Scientific Reports;1/24/2014, p1 

    The mechanisms underlying reduced red blood cell (RBC) deformability during Plasmodium falciparum (Pf) malaria remain poorly understood. Here, we explore the possible involvement of the L-arginine and nitric oxide (NO) pathway on RBC deformability in Pf-infected patients and parasite cultures....

  • VAR2CSA Signatures of High Plasmodium falciparum Parasitemia in the Placenta. Rovira-Vallbona, Eduard; Monteiro, Isadora; Bardají, Azucena; Serra-Casas, Elisa; Neafsey, Daniel E.; Quelhas, Diana; Valim, Clarissa; Alonso, Pedro; Dobaño, Carlota; Ordi, Jaume; Menéndez, Clara; Mayor, Alfredo // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Plasmodium falciparum infected erythrocytes (IE) accumulate in the placenta through the interaction between Duffy-binding like (DBL) domains of parasite-encoded ligand VAR2CSA and chondroitin sulphate-A (CSA) receptor. Polymorphisms in these domains, including DBL2X and DBL3X, may affect their...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics