TITLE

The influence of vitamin D on cardiovascular disease

AUTHOR(S)
Lakemond, Rachel
PUB. DATE
March 2012
SOURCE
Australian Medical Student Journal;2012, Vol. 3 Issue 1, p31
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Vitamin D is essential for many biological functions in the body. Populations that are deficient in vitamin D have increased cardiovascular morbidity and mortality. Current research is controversial, and the evidence base is still developing. This review looks at the interaction between vitamin D levels and cardiovascular disease, including the major cardiovascular risk factors - diabetes, obesity, hyperlipidaemia and hypertension. Methods: A literature review was undertaken through MEDLINE / PubMED / Ovid / Springerlink / Web of Science databases. The terms, "vitamin D", "vitamin D deficiency", "cardiovascular risk", "cardiovascular disease", "structure", "function", "ergocalciferol", "cholecalciferol", "calcitriol", "vitamin D receptors", "1α-hydroxylase", "diabetes", "obesity", "hypercholesterolaemia", "hyperlipidaemia" and "hypertension" were used. Sixty-eight articles were selected and analysed, with preference given to studies published in English and published within recent years. Results: There is a correlation between adequate vitamin D levels and type two diabetes mellitus, but limited research to support this. Obesity, physical inactivity and elevated circulating lipids are more common in vitamin D deficiency. These relationships have not been shown to be causal. Some studies have shown an inverse correlation between hypertension and vitamin D levels, while others have shown no relationship. Conclusion: The studies analysed show there is limited evidence to suggest that cardiovascular disease may be prevented by adequate vitamin D levels. There are few well-designed studies that demonstrate the relationship between the cardiovascular risk factors- diabetes, obesity, hyperlipidaemia, hypertension, and vitamin D. Further research is needed to clarify the influence of vitamin D on cardiovascular disease.
ACCESSION #
85673273

 

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