Plasma and Urine Dimercaptopropanesulfonate Concentrations after Dermal Application of Transdermal DMPS (TD-DMPS)

Cohen, Jennifer P.; Ruha, Anne-Michelle; Curry, Steven C.; Biswas, Kallol; Westenberger, Benjamin; Ye, Wei; Caldwell, Kathleen L.; LoVecchio, Frank; Burkhart, Keith; Samia, Nasr
March 2013
Journal of Medical Toxicology;Mar2013, Vol. 9 Issue 1, p9
Academic Journal
2,3-Dimercaptopropane-1-sulfonate (DMPS) is a metal chelator approved in Europe for oral or intravenous use for heavy metal poisoning. Transdermally applied DMPS (TD-DMPS) is used by some alternative practitioners to treat autism, despite the absence of evidence for its efficacy. We found no literature evaluating the pharmacokinetics of the transdermal route of delivery or the ability of TD-DMPS to enhance urinary mercury elimination. We hypothesized that TD-DMPS is not absorbed. Eight adult volunteers underwent application of 1.5–3 drops/kg of TD-DMPS. Subjects provided 12-h urine collections the day before and day of application. Subjects underwent blood draws at 0, 30, 60,90, 120, and 240 min after TD-DMPS application. Plasma and urine were assayed for the presence of DMPS. Urine was assayed for any change in urinary mercury excretion after DMPS. One control subject ingested 250 mg of oral DMPS and underwent the same urine and blood collections and analyses. No subject had detectable urine DMPS or increased urine mercury excretion after TD-DMPS. One subject had detectable levels of DMPS in the 30-min plasma sample, suspected to be contamination. All other samples for that subject and the other seven subjects showed no detectable plasma DMPS. The control subject had detectable urine and plasma DMPS levels and increased urine mercury excretion. These results indicate that TD-DMPS is not absorbed. There was no increase in urine mercury excretion after TD-DMPS. Our results argue that TD-DMPS is an ineffective metal chelator.


Related Articles

  • ACCUMULATION OF HEAVY METALS BY HIGHER AQUATIC VEGETATION OF ARTIFICIAL CANALS. Bilyk, Tetiana; Shylo, Olga; Karpova, Galyna; Chumanova, Olena // Proceedings of National Aviation University;2014, Vol. 2 Issue 59, p125 

    Accumulation of heavy metals by high plants of artificial canals of Desnyanskiy district in Kyiv was considered. Cleansing ability of different types of submerged and air-water vegetation was compared. Types of plants improving sanitary conditions of reservoirs in urban sites were determined.

  • Toxicological Status of Children with Autism vs. Neurotypical Children and the Association with Autism Severity. Adams, James; Audhya, Tapan; McDonough-Means, Sharon; Rubin, Robert; Quig, David; Geis, Elizabeth; Gehn, Eva; Loresto, Melissa; Mitchell, Jessica; Atwood, Sharon; Barnhouse, Suzanne; Lee, Wondra // Biological Trace Element Research;Feb2013, Vol. 151 Issue 2, p171 

    This study investigates both the level of toxic metals in children with autism and the possible association of those toxic metals with autism severity. This study involved 55 children with autism ages 5-16 years compared to 44 controls with similar age and gender. The study included measurements...

  • Toxic Metals and Autism: Two new studies.  // Latitudes Online;10/31/2010, p7 

    The article reports on two new studies linking autism with high mercury levels or other heavy metal toxins. Lab results for mercury levels were reportedly generated by Vitamin Diagnostics for subjects with autism spectrum disorder. The neurotoxicity of mercury is said to be well-established and...

  • Health risks of heavy metals in the mediterranean mussels as seafood. Stankovic, Slavka; Jovic, Mihajlo // Environmental Chemistry Letters;Jun2012, Vol. 10 Issue 2, p119 

    In recent years, mussels have already become commercially important seafood species worldwide. Mussels accumulate a wide range of metals in their soft tissue. Thus, the determination of accumulated concentrations of heavy metals, such as Pb, Cd, Hg, and As, in mussels is essential because of...

  • EFFECT OF HEAVY METALS ON PISUM SATIVUM LINN. Borah, Mrigakhi; Devi, Ashalata // International Journal of Advanced Biological Research;2012, Vol. 2 Issue 2, p314 

    A pot experiment was carried out to study the responses of Pisum sativum L. growing in Copper, Zinc and Lead treated soil. Three different soil concentrations of each heavy metal were prepared from salts of these metals (100, 200 and 400 mg/Kg for Cu, Zn and Pb) bearing twenty replicates for...

  • UK campaigners question Unilever over India activities; Why environment activists are alleging toxic pollution by the Anglo-Dutch multinational through Mercury contamination.  // FRPT- FMCG Snapshot;5/18/2014, p4 

    The article talks about the protests lodged by the UK Campaign for Justice in Kodaikanal over alleged mercury poisoning in Tamil Nadu, India caused by the mercury thermometer factory owned by a subsidiary of consumer goods company Unilever.

  • Safety Norms for Toys. Marphatia, Ravi // Paintindia;Aug2008, Vol. 58 Issue 8, p70 

    The article reports on the results of a study conducted by Consumer Education and Research Society (CERS) of Ahmedabad, India which reveals the presence of toxic heavy metals in intimate infant articles. According to the study, the presence of toxic substances are within the limits of the Bureau...

  • Assessment of mercury heavy metal toxicity-induced physiochemical and molecular changes in Sesbania grandiflora L. Malar, S.; Sahi, S.; Favas, P.; Venkatachalam, P. // International Journal of Environmental Science & Technology (IJE;Oct2015, Vol. 12 Issue 10, p3273 

    Mercury (Hg) is one of the major toxic heavy metals because it bioaccumulates and biomagnifies in animal and human bodies via the food chain. To eliminate heavy metal contamination, plants are being used as removal agents of pollutants/toxic chemicals from the environment. The present study was...

  • Toxic metal contamination in cattle of Zambia. Yabe, John // Japanese Journal of Veterinary Research;Nov2012, Vol. 60 Issue 4, p212 

    In this article, the author discusses the current status of metal pollution in cattle of Africa. He found that the level of toxic metals in water, soils, and edible vegetables has exceeded the acceptable limits for human consumption. He also found that accumulation of lead and cadmium in cattle...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics