Recurrent pregnancy loss in patients with thyroid dysfunction

Sarkar, Debanjali
December 2012
Indian Journal of Endocrinology & Metabolism;Dec2012 Supplement, Vol. 16, pS350
Academic Journal
Purpose of the Review: Thyroid disturbances are common in women during their reproductive years. Thyroid dysfunction interferes with human reproductive physiology, reduces the likelihood of pregnancy and adversely affects pregnancy outcome, thus becoming relevant in the algorithm of reproductive dysfunction. This review highlights the "gap" in knowledge regarding the contribution of thyroid dysfunction in reproduction. Literature Reviewed: Following implantation, the maintenance of the pregnancy is dependent on a multitude of endocrinological events that will eventually aid in the successful growth and development of the fetus. It is estimated that approximately 8-12% of all pregnancy losses are the result of endocrine factors. Autoimmune thyroid disease is present in around 4% of young females and up to 15% are at risk because they are thyroid antibody-positive. There is a strong relationship between thyroid immunity on one hand and infertility, miscarriage, and thyroid disturbances in pregnancy and postpartum, on the other hand. Even minimal hypothyroidism can increase rates of miscarriage and fetal death and may also have adverse effects on later cognitive development of the offspring. Hyperthyroidism during pregnancy may also have adverse consequences. Pregnant women with subclinical hypothyroidism or thyroid antibodies have an increased risk of complications, especially pre-eclampsia, perinatal mortality, and miscarriage. Universal screening for thyroid hormone abnormalities is not routinely recommended at present, but thyroid function must be examined in female with fetal loss or menstrual disturbances. Practitioners providing health care for women should be alert to thyroid disorders as an underlying etiology for recurrent pregnancy loss.


Related Articles

  • Maternal Subclinical Hypothyroidism, Thyroid Autoimmunity, and the Risk of Miscarriage: A Prospective Cohort Study. Liu, Haixia; Shan, Zhongyan; Li, Chenyan; Mao, Jinyuan; Xie, Xiaochen; Wang, Weiwei; Fan, Chenling; Wang, Hong; Zhang, Hongmei; Han, Cheng; Wang, Xinyi; Liu, Xin; Fan, Yuxin; Bao, Suqing; Teng, Weiping // Thyroid;Nov2014, Vol. 24 Issue 11, p1642 

    Background: Increasing data suggest that subclinical hypothyroidism (SCH) and thyroid autoimmunity (TAI) are associated with adverse pregnancy outcomes, but there are limited data on the association of these conditions in early pregnancy with subsequent miscarriage. Methods: In this prospective...

  • Prevalence and Impact of Thyroid Disorders on Maternal Outcome in Asian-Indian Pregnant Women. Nambiar, Vimal; Jagtap, Varsha S.; Sarathi, Vijaya; Lila, Anurag R.; Kamalanathan, Sadishkumar; Bandgar, Tushar R.; Menon, Padmavathy S.; Shah, Nalini S. // Journal of Thyroid Research;2011, p1 

    Aims. To establish the prevalence and the effect of thyroid dysfunction on pregnancy outcomes in Asian-Indian population. Subjects and Methods. The study cohort comprised of 483 consecutive pregnant women in the first trimester attending the antenatal clinic of a tertiary center in Mumbai,...

  • Presenting results with confidence.  // Journal of Clinical Pathology;Dec2009, Vol. 62 Issue 12, p1059 

    No abstract available.

  • A Novel In-Silico Drug Designing Approach for Identification of Natural Compounds for Treatment of Hypothyroid. Wanjari, Pankhuri; Jayadeepa, R. M. // International Proceedings of Chemical, Biological & Environmenta;2012, Vol. 31, p12 

    Hypothyroidism is an endocrine disorder characterized by abnormally low thyroid hormone production, resulting in the deficiency of thyroid hormone. Hypothyroid can be treated by giving synthetic drug intake of L-thyroxin (T4) and L-triiodothyronine (T3) as a replacement or supplementary therapy...

  • Levothyroxine Therapy in Patients with Thyroid Disease. Mandel, Susan J.; Brent, Gregory A.; Larsen, P. Reed // Annals of Internal Medicine;9/15/93, Vol. 119 Issue 6, p492 

    Discusses the indications for and the proper monitoring of levothyroxine therapy in patients with thyroid disease. Prevalence of overt hypothyroidism in women and men in the U.S; Information on thyroid hormone physiology and thyroid-pituitary regulation; Situations associated with...

  • Pattern of Thyroid Function During Early Pregnancy in Women Diagnosed with Subclinical Hypothyroidism and Treated with l-Thyroxine Is Similar to That in Euthyroid Controls. Christian De Geyter; Sabine Steimann; Beat Müller; Marius E. Kränzlin; Christian Meier // Thyroid;Jan2009, Vol. 19 Issue 1, p53 

    Background:Subclinical hypothyroidism (SCH) is associated with a higher miscarriage rate. It is unclear how the thyroid function in SCH differs from that in euthyroidism during early pregnancy. We intended to determine the regulation of thyroid function in women with SCH receiving constant...

  • Role of red blood cell distribution width (RDW) in thyroid dysfunction. P., Geetha J.; R., Srikrishna // International Journal of Biological & Medical Research;May2012, Vol. 3 Issue 3, p1476 

    Background: Thyroid hormones play an important physiological role in humans. Erythrocyte abnormalities are frequently associated with thyroid dysfunction. However they are rarely investigated and related to the thyroid. Aim: In this study an attempt is made to evaluate Red blood cell...

  • Subclinical Thyroid Disease. Wilson, George R.; Curry Jr., R. Whit // American Family Physician;10/15/2005, Vol. 72 Issue 8, p1517 

    Subclinical thyroid dysfunction is defined as an abnormal serum thyroid-stimulating hormone level (reference range: 0.45 to 4.50 µU per mL) and free thyroxine and triiodothyronine levels within their reference ranges. The management of subclinical thyroid dysfunction is controversial. The...

  • Expression and significance of IGF-1 and IGF-1R in thyroid nodules. Liu, Ying-Jian; Qiang, Wei; Shi, Jing; Lv, Si-Qing; Ji, Mei-Ju; Shi, Bing-Yin // Endocrine (1355008X);Aug2013, Vol. 44 Issue 1, p158 

    There are limitations in the diagnosis of thyroid nodules, especially follicular lesions, and their pathogenesis remains unclear. Insulin-like growth factor-1 (IGF-1) has been implicated in tumor cell apoptosis, transformation, invasion, and metastasis; however, its role in thyroid nodules is...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics