TITLE

Tumor size and effectiveness of electrochemotherapy

AUTHOR(S)
Mali, Barbara; Miklavcic, Damijan; Campana, Luca G.; Cemazar, Maja; Sersa, Gregor; Snoj, Marko; Jarm, Tomaz
PUB. DATE
January 2013
SOURCE
Radiology & Oncology;2013, Vol. 47 Issue 1, p32
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. Electrochemotherapy (ECT) is an effective and safe method for local treatment of tumors. However, relatively large variability in effectiveness of ECT has been observed, which likely results from different treatment conditions and tumor characteristics. The aim of this study was to investigate the relationship between tumor size and effectiveness of a single-session ECT. Materials and methods. A systematic search of various bibliographic databases was performed and nine studies eligible for this study were extracted. Different statistical methods including meta-analysis were applied to analyze the data. Results. The results of analysis based on data from 1466 tumors of any histotype show significantly lower effectiveness of ECT on tumors with maximal diameter equal to or larger than 3 cm (complete response (CR) of 33.3%, objective response (OR) of 68.2%) in comparison to smaller tumors (CR% of 59.5%, OR% of 85.7%). The results of meta-analysis indicated that ECT performed on tumors smaller than 3 cm statistically significantly increases the probability of CR by 31.0% and OR by 24.9% on average in comparison to larger tumors. The analysis of raw data about the size and response of tumors showed statistically significant decrease in effectiveness of ECT progressively with increasing tumor diameter. The biggest drop in CR% was detected at tumor diameters as small as 2 cm. Conclusions. The standard operating procedures for ECT should be reexamined and refined for the treatment of large tumors. We propose that future clinical trials should include accurate ECT treatment planning and/or multiple ECT cycles, besides a prolonged observation for tumor response evaluation.
ACCESSION #
85401324

 

Related Articles

  • Curettage of benign bone tumors and tumor like lesions: A retrospective analysis. Zile Singh Kundu; Gupta, Vinay; Singh Sangwan, Sukhbir; Rana, Parveen // Indian Journal of Orthopaedics;May/Jun2013, Vol. 47 Issue 3, p295 

    Background: Curettage is one of the most common treatment options for benign lytic bone tumors and tumor like lesions. The resultant defect is usually filled. We report our outcome curettage of benign bone tumors and tumor like lesions without filling the cavity. Materials and Methods: We...

  • The effects of a tourniquet used in total knee arthroplasty: a meta-analysis. Wei Zhang; Ning Li; Sifeng Chen; Yang Tan; Al-Aidaros, Mohammed; Liaobin Chen // Journal of Orthopaedic Surgery & Research;2014, Vol. 9 Issue 1, p1 

    Background The purpose of this research is to evaluate the effects of a tourniquet in total knee arthroplasty (TKA). Methods The study was done by randomized controlled trials (RCTs) on the effects of a tourniquet in TKA. All related articles which were published up to June 2013 from Medline,...

  • Patterns of treatment in Australian men following fracture. Otmar, R.; Henry, M. J.; Kotowicz, M. A.; Nicholson, G. C.; Korn, S.; Pasco, J. A. // Osteoporosis International;Jan2011, Vol. 22 Issue 1, p249 

    Summary: This study aimed to describe treatment initiation rates for men who had recently sustained a fracture. Most (75.9%) men potentially eligible for subsidised treatment at the time of fracture remained untreated even after a subsequent fracture. Introduction: This study aimed to describe...

  • Meta-analysis of the effectiveness of Chinese and Western integrative medicine on medium and advanced lung cancer. Yang, Shuo; Cui, Meng; Li, Hai-yan; Zhao, Ying-kai; Gao, Yong-hong; Zhu, Hai-yan // Chinese Journal of Integrative Medicine;Nov2012, Vol. 18 Issue 11, p862 

    Objective: To summarize the effectiveness of Chinese and Western integrative medicine in treating medium and advanced lung cancer, and to provide guidelines for clinical application. Methods: For this metaanalysis, a comparative search of Chinese medicine data in Chinese National Knowledge...

  • Field validation of secondary data sources: a novel measure of representativity applied to a Canadian food outlet database. Clary, Christelle M.; Kestens, Yan // International Journal of Behavioral Nutrition & Physical Activit;2013, Vol. 10, p77 

    Background: Validation studies of secondary datasets used to characterize neighborhood food businesses generally evaluate how accurately the database represents the true situation on the ground. Depending on the research objectives, the characterization of the business environment may tolerate...

  • Predictive Validity of the Braden Scale for Pressure Ulcer Risk: A Meta-analysis. Park, Seong-Hi; Park, Yu-Sun // Journal of Korean Academy of Nursing;2014, Vol. 44 Issue 6, p595 

    Purpose: The Braden Scale is one of the most intensively studied risk assessment scales used in identifying the risk of developing pressure sore. However, not all studies show that the predictive validity of this scale is sufficient. The purpose of this study was to evaluate the Braden Scale for...

  • A Meta-Analysis of Randomized Controlled Trials on Acupuncture for Amblyopia. Xingke Yan; Tiantian Zhu; Chongbing Ma; Anguo Liu; Lili Dong; Junyan Wang // Evidence-based Complementary & Alternative Medicine (eCAM);2013, Vol. 2013, p1 

    Objective. To assess the evidence of efficacy and safety of acupuncture for amblyopia and analyze the current situation of its clinical setting. Methods. We systemically searched Wanfang, Chongqing Weipu Database for Chinese Technical Periodicals (VIP), China National Knowledge Infrastructure...

  • What Can Alcohol Researchers Learn from Research about the Relationship Between Macro-Level Gender Equality and Violence against Women? Roberts, Sarah C. M. // Alcohol & Alcoholism;Mar/Apr2011, Vol. 46 Issue 2, p95 

    Aims: This systematic review focuses on research about macro-level gender equality and violence against women (VAW) and identifies conceptually and theoretically driven hypotheses as well as lessons relevant for alcohol research. Hypotheses include: amelioration—increased equality...

  • Wound drains in posterior spinal surgery: a meta-analysis. Yancheng Liu; Yaomin Li; Jun Miao // Journal of Orthopaedic Surgery & Research;1/22/2016, Vol. 11, p1 

    Background: The use of drains following posterior spinal surgery is controversial. Thus, the aim of this meta-analysis was to review the advantages and adverse effects of closed suction drainage systems in posterior spinal surgery. Methods: All randomized and non-randomized controlled trials...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics