TITLE

Association of FTO Polymorphisms with Obesity and Obesity-Related Outcomes in Portuguese Children

AUTHOR(S)
Albuquerque, David; Nóbrega, Clévio; Manco, Licínio
PUB. DATE
January 2013
SOURCE
PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Several studies have reported an association between single nucleotide polymorphisms in the first intron of the FTO gene and body mass index (BMI) or obesity. However, this association has not yet been studied among the Portuguese population. This study aims to assess the association of three FTO polymorphisms (rs1861868, rs1421085 and rs9939609) with obesity-related outcomes in a sample of Portuguese children. Methods: We examined a total of 730 children, 256 normal-weight (55.9% girls), 320 overweight (45.3% girls) and 154 obese (53.2% girls), aging from 6 to 12-years-old, recruited randomly from public schools in the central region of Portugal. DNA samples were genotyped for the three polymorphisms by allelic discrimination TaqMan assay. Association of the FTO polymorphisms with several anthropometric traits was investigated. Additionally, we tested association with the risk of obesity using overweight and obese vs. normal-weight children. Results: We found significant associations of rs9939609 and rs1421085 polymorphisms with weight, BMI, BMI Z-score, waist circumference and hip circumference, even after age and gender adjustment (p<0.05 in all traits). For rs1861868 polymorphism, marginally significant associations were obtained with weight (p = 0.081) and BMI (p = 0.096) after adjustment for age and gender. In case-control studies, both rs9939609 and rs1421085 polymorphisms were significantly associated with obesity (OR 1.97; 95% CI, 1.08-3.59; p = 0.026; OR 2.11; 95% CI, 1.17-3.81; p = 0.013, respectively) but not with overweight (p>0.05). Haplotype analyses identified two combinations (ACA and GCA) associated with a higher risk of obesity (OR 1.53; 95% CI, 1.06-2.22; p = 0.023; OR 1.73; 95% CI, 1.06-2.87; p = 0.030, respectively). Conclusions: This study provides the first evidence for the association of FTO polymorphisms with anthropometric traits and risk of obesity in Portuguese children.
ACCESSION #
85383584

 

Related Articles

  • Monitoring Childhood Obesity: Assessment of the Weight/Height2 Index. Ellis, Kenneth J.; Abrams, Steven A.; Wong, William W. // American Journal of Epidemiology;1999, Vol. 150 Issue 9, p939 

    The body mass index (BMI), defined as weight/height2, is often used to monitor childhood obesity. BMI values for 979 children (438 White, 283 Black, and 258 Hispanic) aged 3–18 years living in the Houston, Texas, metropolitan area from 1994 to 1998 were compared with percentage of fat...

  • Obesity risk factors in a representative group of Polish prepubertal children. Januszek-Trzciąkowska, Aleksandra; Małecka-Tendera, Ewa; Klimek, Katarzyna; Matusik, Paweł // Archives of Medical Science;Oct2014, Vol. 10 Issue 5, p880 

    Introduction: The study aim was to evaluate risk factors of obesity in Polish children aged 7 to 9 years. Material and methods: A representative group of 2571 children (1268 girls and 1303 boys) was randomly selected according to the European Childhood Obesity Group protocol. Weight and height...

  • Common Predictors of Excessive Adiposity in Children from a Region with High Prevalence of Overweight. Basaldúa, Nancy; Chiquete, Erwin // Annals of Nutrition & Metabolism;Jul2008, Vol. 52 Issue 3, p227 

    Aim: To identify risk factors other than energy intake or expenditure that can predict adiposity and overweight in children from a region with high prevalence of obesity. Methods: We studied 551 children aged 6–12 years (50.5% girls) from a city in the North of Mexico. Tetrapolar...

  • The Effect of Obesity on Self-Esteem among Pre University Iranian Students in Kashan City of Iran April 2009. Alvani, Seyed Reza; Alvani, Shokoofeh // European Journal of Social Sciences;Sep2011, Vol. 24 Issue 1, p48 

    Overweight is one of the most frequent phenomena, which poses serious health risks, emotional disturbances and esthetic and social problems in the world. (Malekzadeh and Mohamad Nejad, 2005), Ayatollahi's (2010) study found that the prevalence of obesity is growing dramatically both in developed...

  • Assessment of Airway Resistance in Normal Trained and Fat Untrained Adolescent Boys Influenced by Exercise Experiences. Mohammadizadeh, Mahmoud Asle; Ghanbarzadeh, Mohsen; Habibi, Abdolhamid; Shakeriyan, Said // Tanaffos;2013, Vol. 12 Issue 1, p42 

    Background: Overweight and obese children are at increased risk of a wide range of health conditions including respiratory diseases. In addition, inactivity can decrease pulmonary function. This study assessed the effect of obesity and inactivity on pulmonary function impairment in adolescents....

  • Field methods in the evaluation of obesity in children and adolescents. Sampei, Miriam Akemi; Sigulem, Dirce Maria // Revista Brasileira de Saude Materno Infantil;jan-mar2009, Vol. 9 Issue 1, p21 

    In large samples, the methods for obtaining information on obesity need to be simple, inexpensive and reasonably accurate. This review deals with articles focusing on various field methods for the evaluation of body composition. The Bioimpedance and Near infrared methods are simple to execute...

  • Effect of protein intake and weight gain velocity on body fat mass at 6 months of age: The EU Childhood Obesity Programme. Escribano, J; Luque, V; Ferre, N; Mendez-Riera, G; Koletzko, B; Grote, V; Demmelmair, H; Bluck, L; Wright, A; Closa-Monasterolo, R // International Journal of Obesity;Apr2012, Vol. 36 Issue 4, p548 

    INTRODUCTION:Higher protein intake during the first year of life is associated with increased weight gain velocity and body mass index (BMI). However, the relationship of protein intake and weight gain velocity with body composition is unclear.OBJECTIVE:To assess if the increases in weight gain...

  • Delivery by caesarean section and risk of obesity in preschool age children: a prospective cohort study. Huh, Susanna Y.; Rifas-Shiman, Sheryl L.; Zera, Chloe A.; Rich Edwards, Janet W.; Oken, Emily; Weiss, Scott T.; Gillman, Matthew W. // Archives of Disease in Childhood;Jul2012, Vol. 97 Issue 7, p610 

    Objective To examine whether delivery by caesarean section is a risk factor for childhood obesity. Design Prospective prebirth cohort study (Project Viva). Setting Eight outpatient multi-specialty practices based in the Boston, Massachusetts area. Participants We recruited women during early...

  • The impact of breastfeeding on FTO-related BMI growth trajectories: an application to the Raine pregnancy cohort study. Abarin, Taraneh; Yan Wu, Yan; Warrington, Nicole; Lye, Stephen; Pennell, Craig; Briollais, Laurent // International Journal of Epidemiology;Dec2012, Vol. 41 Issue 6, p1650 

    Introduction For years, body mass index (BMI) has been used by scientists to track weight problems and obesity in children and adults. Recent studies have implicated the fat mass and obesity gene (FTO) in the increase of BMI in young adults. A longer duration of breastfeeding is known to reduce...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics