TITLE

Prevalence of Carbapenemase-Producing Enterobacteriaceae in a University Hospital in Rabat, Morocco: A 19-Months Prospective Study

AUTHOR(S)
Wartiti, M. A. el; Bahmani, F. Z.; Elouennass, M.; Benouda, A.
PUB. DATE
November 2012
SOURCE
International Arabic Journal of Antimicrobial Agents;2012, Vol. 2 Issue 3, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: This study aims to assess the prevalence of clinical isolates of Enterobacteriaceae with carbapenem resistance, and to characterize the types of carbapenemases produced. Methods: Non-duplicate Enterobacteriaceae (Klebsiella spp, Enterobacter spp and E. coli) clinical isolates collected over 19 months (May 2009 through December 2010) were included in this study. The modifed Hodge test was performed on strains showing reduced ertapenem susceptibility. Isolates that tested positive were sent to the French reference center on emerging resistance for molecular characterization and clone determination. Results: A total of 463 strains were investigated: E. coli 63.9%, Klebsiella spp 27.9% and Enterobacter spp 8.2%. Carbapenemase production occurred in 13 isolates (2.8%). Ten strains produced class D carbapenemases (OXA-48). These included 6 K. pneumoniae, 1 K. oxytoca and 3 E. cloacae. New Delhi metallo-β-lactamase-1 (NDM-1) was produced by three K. pneumoniae strains. Conclusion: The high prevalence of carbapenemases producing Klebsiella and Enterobacter among clinical isolates and the detection of NDM-1 carbapenemase is a source of concern in Morocco. This feature requires setting up an emerging resistance monitoring and surveillance scheme at national level.
ACCESSION #
85226571

 

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