TITLE

Estimation and Comparison of Levels of Salivary Alkaline Phosphatase and Aspartate Aminotransferase in Healthy Subjects and Patients with Gingivitis and Periodontitis: A Cross-Sectional Biochemical Study

AUTHOR(S)
Sah, Nupur; More, Shobha P.; Bhat, Kishore
PUB. DATE
December 2012
SOURCE
Indian Journal of Stomatology;2012, Vol. 3 Issue 4, p244
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim: Host responses to periodontal disease include the production of different enzymes that are released by stromal, epithelial or inflammatory cells. There are important enzymes associated with cell injury and cell death like: aspartate and alanine aminotransferase (AST, ALT), lactate dehydrogenase (LDH), creatine kinase (CK), alkaline and acidic phosphatase (ALP, ACP). Changes in enzymatic activity reflect metabolic changes in the gingiva and periodontium in inflammation. Material and methods: In this study we have examined the activity of ALP and AST in saliva from patients with gingivitis, periodontitis and in saliva from healthy patients. Periodontal disease was determined based on clinical parameters (gingival index (GI), bleeding on probing (BOP) and probing depth (PD). Results: Results obtained showed a statistically significant increase in the levels of ALP and AST in periodontitis patients in comparison to healthy people and gingivitis patients. Conclusions: Based on these results, it can be assumed that activity of these enzymes in saliva, may be useful in diagnosis in periodontal disease.
ACCESSION #
85211677

 

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