TITLE

Bone Morphogenetic Proteins in Craniofacial Surgery: Current Techniques, Clinical Experiences, and the Future of Personalized Stem Cell Therapy

AUTHOR(S)
Chenard, Kristofer E.; Teven, Chad M.; Tong-Chuan He; Reid, Russell R.
PUB. DATE
January 2012
SOURCE
Journal of Biomedicine & Biotechnology;2012, Vol. 2012, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Critical-size osseous defects cannot heal without surgical intervention and can pose a significant challenge to craniofacial reconstruction. Autologous bone grafting is the gold standard for repair but is limited by a donor site morbidity and a potentially inadequate supply of autologous bone. Alternatives to autologous bone grafting include the use of alloplastic and allogenic materials, mesenchymal stemcells, and bone morphogenetic proteins. Bonemorphogenetic proteins (BMPs) are essential mediators of bone formation involved in the regulation of differentiation of osteoprogenitor cells into osteoblasts. Here we focus on the use of BMPs in experimental models of craniofacial surgery and clinical applications of BMPs in the reconstruction of the cranial vault, palate, and mandible and suggest a model for the use of BMPs in personalized stem cell therapies.
ACCESSION #
85115054

 

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