TITLE

Effect of natural honey from Ilam and metformin for improving glycemic control in streptozotocin-induced diabetic rats

AUTHOR(S)
Nasrolahi, Ozra; Heidari, Reza; Rahmani, Fatima; Farokhi, Farah
PUB. DATE
October 2012
SOURCE
Avicenna Journal of Phytomedicine;Autumn2012, Vol. 2 Issue 4, p212
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective(s): Diabetes mellitus is a public health problem and one of the five leading causes of death globally. In the present study, the effect of Metformin with natural honey was investigated on glycemia in the Streptozotocin-induced diabetic rats. Materials and Methods: Thirty Wistar male rats were randomly divided into six groups including C: non diabetic rats received distilled water, CH: non diabetic rats received honey, CD: diabetic rats administered with distilled water, DM: Metformin treated diabetic rats, DH: honey treated diabetic rats, and DMH: diabetic rats treated with a combination of Metformin and natural honey. Diabetes was induced by a single dose of Streptozotocin (65 mg/kg; i.p.). The animals were treated by oral gavage once daily for four weeks. At the end of the treatment period, the animals were sacrificed and their blood samples collected. Amount of glucose, triglyceride (TG), total cholesterol (TC), HDL cholesterol, LDL cholesterol, VLDL cholesterol, total bilirubin, and albumin were determined in serum. Results: Group CD: showed hyperglycemia (252.2�4.1 mg/dl), while level of blood glucose was significantly (p<0.01) reduced in groups DH (124.2�2.7 mg/dl), DM (108.0�3.4 mg/dl), and DMH (115.4�2.1 mg/dl). Honey in combination with Metformin significantly (p<0.01) reduced level of bilirubin but Metformin alone did not reduce bilirubin. Honey alone and in combination with Metformin also significantly reduced triglycerides, total cholesterol, LDL, VLDL and increased HDL, but Metformin did not reduced triglycerides and increased HDL. Conclusion: The results of the present study demonstrated that consuming natural honey with Metformin improves glycemic control and is more useful than consuming Metformin alone. The higher therapeutic effect of Ilam honey on lipid abnormalities than Tualang honey was also evident.
ACCESSION #
85102532

 

Related Articles

  • Antidiabetic Drugs in Combination with Hydroxychloroquine Improve Glycemic Control in Alloxan Induced Diabetic Rats. Zannah, Shaheda; Islam, Md. Saiful; Towheedur Rahman, A. F. M.; Asaduzzaman, Md.; Al Bari, Abdul Alim; Ali, Yusuf; Islam, Gazi Jahirul; Khurshid Alam, A. H. M.; Ali, Hazrat; Rashid, Mamunur // Pharmacology & Pharmacy;Jun2014, Vol. 5 Issue 7, p725 

    Worldwide prevalence of diabetes mellitus has become an issue of great concern in current decades. This life threatening disease is associated with worsening of glycemic control and progressive metabolic dysfunctions. Objective: Current study aimed to investigate the effect of hydroxychloroquine...

  • HYPOGLYCAEMIC ACTIVITY OF AERIAL PARTS OF ARGEMONE MEXICANA L. IN EXPERIMENTAL RAT MODELS. Rout, S. P.; Kar, D. M.; Mandal, P. K. // International Journal of Pharmacy & Pharmaceutical Sciences;Oct2011 Supplement, Vol. 3, p533 

    Experimental Design, Materials and Methods: The aim of the present study was focus on, to the evaluation of hypoglycaemic activity of hydro-alcoholic extract of aerial parts of Argemone mexicana L. (HAAM). The study was carried out on normal, glucose loaded, and streptozotocin (STZ) induced...

  • Ethanolic Extract of Ocimum Grattissimum Leaves (Linn.) Rapidly Lowers Blood Glucose Levels in Diabetic Wistar Rats. Onaolapo, Adejoke Y.; Onaolapo, Olakunle J.; Adewole, Stephen A. // Macedonian Journal of Medical Sciences;Dec2011, Vol. 4 Issue 4, p351 

    Background: The present study was undertaken to investigate the effects of ethanolic extracts of Ocimum gratissimum leaves on blood glucose and weight parameters in streptozotocin induced diabetic Wistar rats. Aim: The aim was to provide information on the glucose lowering potentials of...

  • Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice. Ezz El-Arab, Aly M.; Girgis, Shenouda M.; Hegazy, Eman M.; Abd El-Khalek, Azzat B. // BMC Complementary & Alternative Medicine;2006, Vol. 6, p6 

    Background: Bee honey is a functional food which has a unique composition, antimicrobial properties and bifidogenic effect. In order to assess whether honey can inhibit the toxic effect of mycotoxins, the present study was undertaken. Methods: Production of biomass and toxins by Aspergillus...

  • Antioxidant Effect of Curcumin Extracts in Induced Diabetic Wister Rats. Hussein, H. K.; Abu-Zinadah, O. A. // International Journal of Zoological Research;2010, Vol. 6 Issue 4, p266 

    No abstract available.

  • Ocimum Gratissimum Linn Causes Dose Dependent Hepatotoxicity in Streptozotocin-Induced Diabetic Wistar Rats. Onaolapo, Adejoke Y.; Onaolapo, Olakunle J. // Macedonian Journal of Medical Sciences;Mar2012, Vol. 5 Issue 1, p17 

    Aim: Hepatoprotective effects of Ethanolic extract Ocimum gratissimum leaves (O. gratissimum) in streptozotocin-induced diabetic rats was studied. Material and Methods: Thirty-six adult rats were assigned into six groups (A, B, C, D, E and F) of six rats each. Group A was the control, while...

  • The Effect of Hydroalcoholic Extract of Artemisia (Artemisia herba-alba) and Markers of Liver Damage Compared with Metformin in Streptozotocin-Induced Diabetic Rats. Farhad, Kouhpeyma; Hossein, Kargar Jahromi; Shahla, Zahiri; Sara, Azhdari; Mohammad, Farzam; Saeid, Mahmoudi Teimourabad // Advances in Environmental Biology;Apr2013, Vol. 7 Issue 4, p743 

    Introduction: Studies indicate that Artemisia extract caused a significant decrease in glucose levels in diabetic animals. The aim of this study was to investigate the effect of Artemisia plant extracts to improve diabetes complications and markers of liver damage, it is. Materials and Methods:...

  • Sitagliptin, sitagliptin and metformin, or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats. Sharma, Ashish Kumar; Sharma, Akash; Kumari, Rita; Kishore, Kunal; Sharma, Divya; Srinivasan, Bharthu Parthsarthi; Sharma, Ashok; Singh, Santosh Kumar; Gaur, Samir; Jatav, Vijay Singh; Sharma, Prashant; Srivastava, Varnika; Joshi, Sneha; Joshi, Megha; Dhakad, Prashant Kumar; Kanawat, Davender Singh; Mishra, Akanksha; Sharma, Anil; Singh, Dharmendra; Singh, Ravinder Pal // Journal of Biomedical Research;May2012, Vol. 26 Issue 3, p200 

    Abstract: Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neu-ropathy, and thoracoabdominal neuropathy. In this study, type 2...

  • ANTI-HYPERGLYCEMIC EFFECT ANNONA RETICULATA L. LEAVES ON EXPERIMENTAL DIABETIC RAT MODEL. ROUT, SOUMYA P.; KAR, DURGA M.; MOHAPATRA, SANTOSH B.; SWAIN, SHARADA P. // Asian Journal of Pharmaceutical & Clinical Research;Jan2013 Supplement, p56 

    Context: Annona reticulata Linn (Annonaceae) commonly known as bullock's heart is widely distributed all over India and leaves are used as insecticides, anthelmintic, styptic and are also used externally as suppurant. Objective: The present study has been designed to determine the effectiveness...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics