TITLE

Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats

AUTHOR(S)
Imanishi, Tamotsu; Hossain, Muhammad Mubarak; Suzuki, Tadahiko; Ping Xu; Sato, Itaru; Kobayashi, Haruo
PUB. DATE
January 2012
SOURCE
Advances in Pharmacological Sciences;2012, Vol. 2012, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Anticholinesterases (antiChEs) are used to treat Alzheimer's disease. The comparative effects of two antiChEs, methanesulfonyl fluoride (MSF) and donepezil, on the extracellular levels of ACh in the hippocampus were investigated by in vivo microdialysis in freely moving rats. MSF at 1 and 2mg/kg produced a dose-dependent increase in ACh efflux from 10 min to at least 3 hrs after injection. At 2 mg/kg, the increase was still present at 24 hr. Donepezil at 1mg/kg showed a similar but smaller effect, and, paradoxically, 2mg/kg showed no consistent effect. MSF at 1 and 2 mg/kg decreased acetylcholinesterase activity in the hippocampus to 54.8 and 20.1% of control, respectively. These results suggest that MSF is a suitable candidate for the treatment of Alzheimer's disease.
ACCESSION #
84996064

 

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