TITLE

Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives

AUTHOR(S)
Rani, Mamta; Yusuf, Mohamad
PUB. DATE
December 2012
SOURCE
European Journal of Chemistry;Dec2012, Vol. 3 Issue 4, p406
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Five new compounds, bis-pyrazoline derivatives (2a-e) with antibacterial properties, built around the alkyl chains of varying lengths were prepared via reaction of various 1-ω-alkoxybis- chalcones with N-substituted thiosemicarbazide in ethanolic NaOH solution. The antibacterial activity of these compounds were evaluated by the disk diffusion method against two Gram-positive and two Gram-negative bacteria and the minimum inhibitory concentration were determined. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, ESI mass spectrometry and their purities were also confirmed by elemental analyses. The formation and stereochemical features of the compounds, 2a-e, are found to be independent of the internal spacer length. The results showed that compounds 2a and 2e are better antibacterial agent compared to Gentamicin and Tetracycline.
ACCESSION #
84927462

 

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