A Remarkable Case of Micro-Endemism in Laonastes aenigmamus (Diatomyidae, Rodentia) Revealed by Nuclear and Mitochondrial DNA Sequence Data

Nicolas, Violaine; Herbreteau, Vincent; Couloux, Arnaud; Keovichit, Kham; Douangboupha, Bounneuang; Hugot, Jean-Pierre
November 2012
PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1
Academic Journal
L. aenigmamus is endemic to the limestone formations of the Khammuan Province (Lao PDR), and is strongly specialized ecologically. From the survey of 137 individuals collected from 38 localities, we studied the phylogeography of this species using one mitochondrial (Cyt b) and two nuclear genes (BFIBR and GHR). Cyt b analyses reveal a strong mtDNA phylogeographical structure: 8 major geographical clades differing by 5-14% sequence divergence were identified, most of them corresponding to distinct karst areas. Nuclear markers display congruent results but with a less genetic structuring. Together, the data strongly suggest an inland insular model for Laonastes population structure. With 8 to 16 evolutionary significant units in a small area (about 200650 km) this represents an exceptional example of micro-endemism. Our results suggest that L. aenigmamus may represent a complex of species and/or sub-species. The common ancestor of all Laonastes may have been widely distributed within the limestone formations of the Khammuan Province at the end of Miocene/ beginning of the Pliocene. Parallel events of karst fragmentation and population isolation would have occurred during the Pleistocene or/and the end of the Pliocene. The limited gene flow detected between populations from different karst blocks restrains the likelihood of survival of Laonastes. This work increases the necessity for a strict protection of this rare animal and its habitat and provides exclusive information, essential to the organization of its protection.


Related Articles

  • Cystic Lung Disease in Genetic Syndromes with Deficient Tumor Suppressor Gene Function. Daccord, Cécile; Nicod, Laurent P.; Lazor, Romain // Respiration;Dec2017, Vol. 94 Issue 6, p467 

    Cystic lung diseases constitute a distinct group of rare lung disorders, among which two result from monogenic defects affecting tumor suppressor genes: lymphangioleiomyomatosis, either sporadic or associated with tuberous sclerosis complex, and Birt-Hogg-Dubé syndrome. These disorders have...

  • Birt-Hogg-Dubé syndrome: clinicopathological features of the lung. Furuya, Mitsuko; Nakatani, Yukio // Journal of Clinical Pathology;Mar2013, Vol. 66 Issue 3, p178 

    Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant inherited disorder characterised by fibrofolliculomas, renal tumours, pulmonary cysts and pneumothorax. The pulmonary cysts and repeated episodes of pneumothorax are the clinical hallmarks for discovering families affected by the...

  • Pulmonary cystic disease associated with integumentary and renal manifestations. Cayetano, Katherine S.; Albertson, Timothy E.; Chan, Andrew L. // Journal of Biomedical Research;2013, Vol. 27 Issue 6, p515 

    A 69-year-old man with multiple skin lesions on his face, neck and upper torso, which first appeared in the 3rd decade of his life, was admitted to our hospital. He had cystic changes in his lungs noted on chest computed tomography (CT) scanning, as well as a left kidney mass. This patient...

  • Human Folliculin Delays Cell Cycle Progression through Late S and G2/M-Phases: Effect of Phosphorylation and Tumor Associated Mutations. Laviolette, Laura A.; Wilson, Jonas; Koller, Julia; Neil, Christopher; Hulick, Peter; Rejtar, Tomas; Karger, Barry; Teh, Bin Tean; Iliopoulos, Othon // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    The Birt-Hogg-Dube disease occurs as a result of germline mutations in the human Folliculin gene (FLCN), and is characterized by clinical features including fibrofolliculomas, lung cysts and multifocal renal neoplasia. Clinical and genetic evidence suggest that FLCN acts as a tumor suppressor...

  • Where Birt-Hogg-Dubé meets Cowden Syndrome: mirrored genetic defects in two cases of syndromic oncocytic tumours. Pradella, Laura Maria; Lang, Martin; Kurelac, Ivana; Mariani, Elisa; Guerra, Flora; Zuntini, Roberta; Tallini, Giovanni; MacKay, Alan; Reis-Filho, Jorge S; Seri, Marco; Turchetti, Daniela; Gasparre, Giuseppe // European Journal of Human Genetics;Oct2013, Vol. 21 Issue 10, p1169 

    Birt-Hogg-Dubè (BHD) is an autosomal dominant syndrome characterised by skin fibrofolliculomas, lung cysts, spontaneous pneumothorax and renal cancer. The association of benign cutaneous lesions and increased cancer risk is also a feature of Cowden Syndrome (CS), an autosomal dominant disease...

  • Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN. Hasumi, Hisashi; Baba, Masaya; Hasumi, Yukiko; Huang, Ying; Oh, Hyoungbin; Hughes, Robert M.; Klein, Mara E.; Takikita, Shoichi; Nagashima, Kunio; Schmidt, Laura S.; Linehan, W. Marston // JNCI: Journal of the National Cancer Institute;Nov2012, Vol. 104 Issue 22, p1750 

    Background Birt-Hogg-Dubé (BHD) syndrome is a hereditary hamartoma syndrome that predisposes patients to develop hair follicle tumors, lung cysts, and kidney cancer. Genetic studies of BHD patients have uncovered the causative gene, FLCN, but its function is incompletely understood. Methods...

  • Topical Rapamycin as a Treatment for Fibrofolliculomas in Birt-Hogg-Dubé Syndrome: A Double-Blind Placebo-Controlled Randomized Split-Face Trial. Gijezen, Lieke M. C.; Vernooij, Marigje; Martens, Herm; Oduber, Charlene E. U.; Henquet, Charles J. M.; Starink, Theo M.; Prins, Martin H.; Menko, Fred H.; Nelemans, Patty J.; van Steensel, Maurice A. M. // PLoS ONE;Jun2014, Vol. 9 Issue 6, p1 

    Background: Birt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominant disorder characterised by the occurrence of benign, mostly facial, skin tumours called fibrofolliculomas, multiple lung cysts, spontaneous pneumothorax and an increased renal cancer risk. Current treatments for...

  • Knockdown of Slingshot 2 (SSH2) serine phosphatase induces Caspase3 activation in human carcinoma cell lines with the loss of the Birt-Hogg-Dubé tumour suppressor gene (FLCN). Lu, X; Boora, U; Seabra, L; Rabai, E M; Fenton, J; Reiman, A; Nagy, Z; Maher, E R // Oncogene;2/20/2014, Vol. 33 Issue 8, p956 

    Birt-Hogg-Dubé (BHD) syndrome, is a dominantly inherited familial cancer syndrome associated with susceptibility to renal cell carcinoma (RCC) caused by inactivating mutations in the folliculin (FLCN) gene. The precise functions of the FLCN gene product are still under investigation but RCC...

  • Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival. Possik, Elite; Jalali, Zahra; Nouët, Yann; Yan, Ming; Gingras, Marie-Claude; Schmeisser, Kathrin; Panaite, Lorena; Dupuy, Fanny; Kharitidi, Dmitri; Chotard, Laëtitia; Jones, Russell G.; Hall, David H.; Pause, Arnim // PLoS Genetics;Apr2014, Vol. 10 Issue 4, p1 

    Dysregulation of AMPK signaling has been implicated in many human diseases, which emphasizes the importance of characterizing AMPK regulators. The tumor suppressor FLCN, responsible for the Birt-Hogg Dubé renal neoplasia syndrome (BHD), is an AMPK-binding partner but the genetic and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics