Small but Significant: Inter- and Intrapatient Variations in iPS Cell-based Disease Modeling

Sgodda, Malte; Cantz, Tobias
January 2013
Molecular Therapy;Jan2013, Vol. 21 Issue 1, p5
Academic Journal
The article presents a study which discusses the use of intra-patient variations in induced pluripotent stem (IPS) cells based transplants for disease modeling. The study uses disease modeling of patient specific IPS cell and reprogramming with pluripotency associated transcriptome or epigenome. Result shows that human infection specific IPS cell lines demonstrates significant intra and inter sample inconsistency that should be addressed to tissue functional derivatization.


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