TITLE

Small but Significant: Inter- and Intrapatient Variations in iPS Cell-based Disease Modeling

AUTHOR(S)
Sgodda, Malte; Cantz, Tobias
PUB. DATE
January 2013
SOURCE
Molecular Therapy;Jan2013, Vol. 21 Issue 1, p5
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study which discusses the use of intra-patient variations in induced pluripotent stem (IPS) cells based transplants for disease modeling. The study uses disease modeling of patient specific IPS cell and reprogramming with pluripotency associated transcriptome or epigenome. Result shows that human infection specific IPS cell lines demonstrates significant intra and inter sample inconsistency that should be addressed to tissue functional derivatization.
ACCESSION #
84622361

 

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