Targeting microRNAs to modulate TRAIL-induced apoptosis of cancer cells

Lu, T; Shao, N; Ji, C
January 2013
Cancer Gene Therapy;Jan2013, Vol. 20 Issue 1, p33
Academic Journal
MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs, which are evolutionarily conserved and function as regulators of gene expression. These molecules are involved in numerous biological processes including differentiation, development, proliferation and apoptosis. Further investigation identifies that miRNAs may act as either potent oncogenes or tumor-suppressor genes, linking to cancer initiation and progression. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), as a member of the TNF family, is an attractive therapeutic target in cancer because it directly induces tumor cell apoptosis and has no cytotoxicity to normal cell types in vitro or in vivo. However, the resistance to TRAIL-induced apoptosis limits its clinical effectiveness. Interestingly, several studies convincingly demonstrate a role of miRNAs in modulating sensitive/resistant phenotypes to TRAIL. Here, we review the current findings about miRNAs involved in TRAIL-induced apoptosis in different cancers.


Related Articles

  • miR-137 Inhibits the Invasion of Melanoma Cells through Downregulation of Multiple Oncogenic Target Genes. Luo, Chonglin; Tetteh, Paul W; Merz, Patrick R; Dickes, Elke; Abukiwan, Alia; Hotz-Wagenblatt, Agnes; Holland-Cunz, Stefan; Sinnberg, Tobias; Schittek, Birgit; Schadendorf, Dirk; Diederichs, Sven; Eichm├╝ller, Stefan B // Journal of Investigative Dermatology;Mar2013, Vol. 133 Issue 3, p768 

    MicroRNAs are small noncoding RNAs that regulate gene expression and have important roles in various types of cancer. Previously, miR-137 was reported to act as a tumor suppressor in different cancers, including malignant melanoma. In this study, we show that low miR-137 expression is correlated...

  • MicroRNA-376c Inhibits Cell Proliferation and Invasion in Osteosarcoma by Targeting to Transforming Growth Factor-Alpha. Jin, Yi; Peng, Dan; Shen, Yi; Xu, Min; Liang, Ying; Xiao, Bowen; Lu, Jing // DNA & Cell Biology;Jun2013, Vol. 32 Issue 6, p302 

    MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-376c expression level was decreased while transforming growth factor-alpha (TGFA) mRNA expression levels...

  • MiRNA regulation of TRAIL expression exerts selective cytotoxicity to prostate carcinoma cells. Huo, Wei; Jin, Ning; Fan, Li; Wang, Weihua // Molecular & Cellular Biochemistry;Mar2014, Vol. 388 Issue 1/2, p123 

    Prostate carcinoma is the most common cancer for men and among the leading cancer-related causes. Many evidences have shown that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) potently induces apoptosis in cancer cells, and thus, is a promising biologic agent for prostate...

  • Systematic Transcriptome Wide Analysis of lncRNA-miRNA Interactions. Jalali, Saakshi; Bhartiya, Deeksha; Lalwani, Mukesh Kumar; Sivasubbu, Sridhar; Scaria, Vinod // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Background: Long noncoding RNAs (lncRNAs) are a recently discovered class of non-protein coding RNAs, which have now increasingly been shown to be involved in a wide variety of biological processes as regulatory molecules. The functional role of many of the members of this class has been an...

  • MicroRNAs in control of cardiac hypertrophy. Da Costa Martins, Paula A.; De Windt, Leon J. // Cardiovascular Research;Mar2012, Vol. 93 Issue 4, p563 

    MicroRNAs refer to a subfamily of small non-coding RNA species that are designed to influence gene expression in nearly all cell types studied to date. Studies from the past decade have demonstrated that microRNAs are atypically expressed in the cardiovascular system under specific pathological...

  • MiR-133a suppresses the migration and invasion of esophageal cancer cells by targeting the EMT regulator SOX4. Shujun Li; Xuebo Qin; Yang Li; Xun Zhang; Ren Niu; Helin Zhang; Airong Cui; Wenting An; Xiaolu Wang // American Journal of Translational Research;Sep2015, Vol. 7 Issue 8, p1390 

    MicroRNAs (miRNAs) are small, non-coding RNAs which can function as oncogenes or tumor suppressor genes in human cancers. In the present study, we demonstrated that the expression ofmiR-133a was dramatically decreased in examined esophageal squamous cell carcinoma (ESCC) cell lines and clinical...

  • MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells. Wang, Zheng-ming; Du, Wen-jun; Piazza, Gary A; Xi, Yaguang // Acta Pharmacologica Sinica;Nov2013, Vol. 34 Issue 11, p1374 

    MicroRNAs (miRNAs) are small non-coding RNA molecules, whose primary function is to regulate gene expression at the post-transcriptional/translational levels. MiRNAs play crucial roles in normal biological processes and are commonly dys-regulated in human diseases. Stem cells are regarded as the...

  • Development of Novel antimiRzymes for Targeted Inhibition of miR-21 Expression in Solid Cancer Cells. Larcher, Leon M.; Wang, Tao; Veedu, Rakesh N. // Molecules;7/1/2019, Vol. 24 Issue 13, p2489 

    MicroRNAs (miRNAs) are short non-coding RNAs that are involved in the regulation of gene expression. Previous reports showed an over-expression of miRNA-21 (miR-21) in various cancer cells, and its up-regulation is closely related to cancer initiation, proliferation and metastasis. In this work,...

  • MicroRNA-200b regulates cyclin D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells. Xia, Wei; Li, Jie; Chen, Liucun; Huang, Baochun; Li, Shaohua; Yang, Guang; Ding, Hongmei; Wang, Fang; Liu, Nongle; Zhao, Qiang; Fang, Tao; Song, Tao; Wang, Tianyou; Shao, Ningsheng // Molecular & Cellular Biochemistry;Nov2010, Vol. 344 Issue 1/2, p261 

    MicroRNAs (miRNAs) are endogenous non-coding small RNAs that inhibit gene expression post-transcriptionally. By regulating their target genes, miRNAs play important roles in tumor generation and development. Recently, the mir-200 family was revealed to inhibit the epithelial-mesenchymal...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics