TITLE

Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases

AUTHOR(S)
Andreou, A.; Koh, D.; Collins, D.; Blackledge, M.; Wallace, T.; Leach, M.; Orton, M.
PUB. DATE
February 2013
SOURCE
European Radiology;Feb2013, Vol. 23 Issue 2, p428
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To determine the measurement reproducibility of perfusion fraction f, pseudodiffusion coefficient D and diffusion coefficient D in colorectal liver metastases and normal liver. Methods: Fourteen patients with known colorectal liver metastases were examined twice using respiratory-triggered echo-planar DW-MRI with eight b values (0 to 900 s/mm) 1 h apart. Regions of interests were drawn around target metastasis and normal liver in each patient to derive ADC (all b values), ADC ( b values ≥100 s/mm) and intravoxel incoherent motion (IVIM) parameters f, D and D by least squares data fitting. Short-term measurement reproducibility of median ADC, ADC, f, D and D values were derived from Bland-Altman analysis. Results: The measurement reproducibility for ADC, ADC and D was worst in colorectal liver metastases (−21 % to +25 %) compared with liver parenchyma (−6 % to +8 %). Poor measurement reproducibility was observed for the perfusion-sensitive parameters of f (−75 % to +241 %) and D (−89 % to +2,120 %) in metastases, and to a lesser extent the f (−24 % to +25 %) and D* (−31 % to +59 %) of liver. Conclusions: Estimates of f and D derived from the widely used least squares IVIM fitting showed poor measurement reproducibility. Efforts should be made to improve the measurement reproducibility of perfusion-sensitive IVIM parameters. Key Points: • Quantitative diffusion-weighted MRI parameters are increasingly used for clinical management decisions. • However perfusion-sensitive intravoxel incoherent motion (IVIM) parameters showed poor measurement reproducibility. • Measurement reproducibility of IVIM parameters was worse in metastases than normal liver. • Efforts to improve measurement reproducibility of IVIM parameters should be explored.
ACCESSION #
84581162

 

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