Effects of Jatropha curcas leaves on common Dermatophytes and causative agent of Pityriasis versicolor in Rivers State, Nigeria

Mbakwem-Aniebo, C.; Okoyomo, E. P.; Ogugbue, C. J.; Okonko, I. O.
December 2012
Nature & Science;Dec2012, Vol. 10 Issue 12, p151
Academic Journal
The antifungal activity of Jatropha curcas leaves used by traditional medicine practitioners against the three major Dermatophytes - Trichophyton, Microsporum, Epidermophyton together with Malassezia furfur [the causative agent of Pityriasis versicolor (Eczema)], was studied by well-in-agar diffusion technique using different concentrations of ethanolic extracts. Isolates from the scalp, skin, toes and feet of forty individuals (mainly children) were obtained in four locations namely Aluu, Choba, Rumuosi and Emohua areas of Rivers State, Nigeria. The study revealed a significant inhibitory effect of Jatropha curcas leaves on the fungal isolates at five different concentrations of 250mg/ml, 200mg/ml, 150mg/ml, 100mg/ml and 50mg/ml used. Assessment of the various minimum inhibitory concentrations (MIC) showed that Jatropha curcas leaves have the most potential for use as an antidermatophytic agent. The minimum inhibitory concentration (MIC) of the ethanol extract was between 19.95 and 79.43 mg/ml. The zones of inhibition exhibited by the extracts against the test fungal species ranged between 0 and 20mm. The ability of the crude stem extracts of J. curcas to inhibit the growth of fungi is an indication of its broad spectrum antifungal potential which may be employed in the management of fungal infections. The implications of these findings in the use of Jatropha curcas in traditional medicine are discussed.


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