TITLE

Modulation of Antioxidant Enzyme Expression by PTU-Induced Hypothyroidism in Cerebral Cortex of Postnatal Rat Brain

AUTHOR(S)
Bhanja, Shravani; Jena, Srikanta
PUB. DATE
January 2013
SOURCE
Neurochemical Research;Jan2013, Vol. 38 Issue 1, p42
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study aimed to elucidate the effect of 6- n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameters and expression of antioxidant enzymes in cerebral cortex of rat brain during postnatal development. A significant decrease in levels of lipid peroxidation and HO were seen in 7 and 30 days old PTU-treated rats with respect to their controls. Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls. However, increase in translated product of CAT was seen in all age groups of PTU-treated rats. Glutathione peroxidase activity was decreased in 7 days and increased in 15 days old PTU-treated rats with respect to their control groups. Histological sections clearly show a decline in neuronal migration with neurons packed together in the hypothyroid group as compared to the control.
ACCESSION #
84402971

 

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