TITLE

Red Blood Cell Distribution Width in 'Non-Dippers' versus 'Dippers'

AUTHOR(S)
Gunebakmaz, Ozgur; Kaya, Mehmet G.; Duran, Mustafa; Akpek, Mahmut; Elcik, Deniz; Eryol, Namık Kemal
PUB. DATE
November 2012
SOURCE
Cardiology;Nov2012, Vol. 123 Issue 3, p154
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: Because both high red cell distribution width (RDW) and non-dipping hypertension are closely related to adverse cardiovascular outcomes and higher inflammatory status, we aimed to investigate whether there is any relationship between RDW and dipping/non-dipping hypertension status. Methods: The present study involved 123 hypertensive patients and 65 age- and gender-matched healthy, normotensive subjects. Hypertensive patients were divided into two groups: 56 dipper patients (20 males, mean age 51.9 ± 15.3 years) and 67 non-dipper patients (27 males, mean age 55.6 ± 15.0 years). If the systolic daytime blood pressure (BP) of the patients decreased by at least 10% during the nighttime, these subjects were 'dippers', and all other subjects were 'non-dippers'. Results: Both dipper patients and non-dipper patients had higher levels of RDW compared to normotensives (13.5 ± 0.89 and 14.1 ± 1.33 vs. 13.0 ± 1.42%, p = 0.027 and p <0.001, respectively). Also RDW values in non-dippers were statistically higher compared to those in dippers (p = 0.008). Although there were negative correlations between RDW values and nocturnal systolic BP fall (p = 0.027, r = -0.199) and diastolic BP fall (p = 0.383, r = -0.079) in all hypertensive patients, these correlations did not reach a statistically significant level. Conclusion: Our study demonstrates that non-dippers have high RDW levels compared to both dippers and controls. Copyright © 2012 S. Karger AG, Basel
ACCESSION #
83816500

 

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