Red Blood Cell Distribution Width in 'Non-Dippers' versus 'Dippers'

Gunebakmaz, Ozgur; Kaya, Mehmet G.; Duran, Mustafa; Akpek, Mahmut; Elcik, Deniz; Eryol, Namık Kemal
November 2012
Cardiology;Nov2012, Vol. 123 Issue 3, p154
Academic Journal
Objectives: Because both high red cell distribution width (RDW) and non-dipping hypertension are closely related to adverse cardiovascular outcomes and higher inflammatory status, we aimed to investigate whether there is any relationship between RDW and dipping/non-dipping hypertension status. Methods: The present study involved 123 hypertensive patients and 65 age- and gender-matched healthy, normotensive subjects. Hypertensive patients were divided into two groups: 56 dipper patients (20 males, mean age 51.9 ± 15.3 years) and 67 non-dipper patients (27 males, mean age 55.6 ± 15.0 years). If the systolic daytime blood pressure (BP) of the patients decreased by at least 10% during the nighttime, these subjects were 'dippers', and all other subjects were 'non-dippers'. Results: Both dipper patients and non-dipper patients had higher levels of RDW compared to normotensives (13.5 ± 0.89 and 14.1 ± 1.33 vs. 13.0 ± 1.42%, p = 0.027 and p <0.001, respectively). Also RDW values in non-dippers were statistically higher compared to those in dippers (p = 0.008). Although there were negative correlations between RDW values and nocturnal systolic BP fall (p = 0.027, r = -0.199) and diastolic BP fall (p = 0.383, r = -0.079) in all hypertensive patients, these correlations did not reach a statistically significant level. Conclusion: Our study demonstrates that non-dippers have high RDW levels compared to both dippers and controls. Copyright © 2012 S. Karger AG, Basel


Related Articles

  • Relationship between serum bilirubin concentration and nondipper hypertension. Demir, Mehmet; Demir, Canan; Keçeoğlu, Serdar // International Journal of Clinical & Experimental Medicine;2014, Vol. 7 Issue 5, p1454 

    Background: Although nondipper hypertension has been associated with increased cardiovascular morbidity and mortality, the relationship between bilirubin levels and nondipper hypertension remains unclear. Several studies have demonstrated that higher serum bilirubin levels inhibit inflammation...

  • Effect of One-Week Salt Restriction on Blood Pressure Variability in Hypertensive Patients with Type 2 Diabetes. Iuchi, Hiroyuki; Sakamoto, Masaya; Suzuki, Hirofumi; Kayama, Yosuke; Ohashi, Kennosuke; Hayashi, Takeshi; Ishizawa, Sho; Yokota, Tamotsu; Tojo, Katsuyoshi; Yoshimura, Michihiro; Utsunomiya, Kazunori // PLoS ONE;1/5/2016, Vol. 11 Issue 1, p1 

    Background: Increased short-term blood pressure (BP) variability on 24-hour ambulatory BP monitoring (ABPM) is known to be a risk factor for cardiovascular events. However, very few studies have evaluated the effect of salt restriction on BP variability particularly in hypertensive patients...

  • Ghrelin and its promoter variant associated with cardiac hypertrophy. Ukkola, O; Pääkkö, T; Kesäniemi, Y A // Journal of Human Hypertension;Jul2012, Vol. 26 Issue 7, p452 

    The roles of ghrelin, a peptide hormone that has a role in regulating food intake and energy homeostasis, in the cardiovascular system have not yet been unambiguously established. We evaluated the association between plasma ghrelin concentrations and −501A>C single-nucleotide polymorphism...

  • Electrocardiographic Left Ventricular Hypertrophy Criteria and Ambulatory Blood Pressure Monitoring Parameters in Adults. Gómez-Marcos, Manuel A.; Recio-Rodríguez, Jose I.; Patino-Alonso, María C; Agudo-Conde, Cristina; Fernandez-Alonso, Carmen; Martinez Vizcaino, Vicente; Cantera, Carlos Martin; Guenaga-Saenz, Nahia; González-Viejo, Natividad; García-Ortiz, Luis // American Journal of Hypertension;Mar2014, Vol. 27 Issue 3, p355 

    BACKGROUND To examine the relationship between ambulatory blood pressure monitoring parameters (ABPM) and electrocardiographic criteria for left-ventricular hypertrophy (LVH) in adults. METHODS This study analyzed 1,544 subjects from the EVIDENT study (mean age = 55±14 years; 61% women). A...

  • Factors Associated With Glomerular Hyperfiltration in the Early Stage of Hypertension. Palatini, Paolo; Dorigatti, Francesca; Saladini, Francesca; Benetti, Elisabetta; Mos, Lucio; Mazzer, Adriano; Zanata, Giuseppe; Garavelli, Guido; Casiglia, Edoardo // American Journal of Hypertension;Sep2012, Vol. 25 Issue 9, p1011 

    BackgroundGlomerular hyperfiltration predicts development of nephropathy in hypertension but the factors responsible for increased glomerular filtration rate (GFR) are not well known. Aim of this study was to examine which clinical variables influence GFR in the early stage of...

  • Twenty-four-Hour Profile of Central Blood Pressure and Central-to-Peripheral Systolic Pressure Amplification. Jankowski, Piotr; Bednarek, Agnieszka; Olszanecka, Agnieszka; Windak, Adam; Kawecka-Jaszcz, Kalina; Czarnecka, Danuta // American Journal of Hypertension;Jan2013, Vol. 26 Issue 1, p27 

    BACKGROUND The significant difference in central and peripheral blood pressure (BP) values has only recently been widely recognized. Ambulatory BP monitoring has been shown to have advantages over office BP measurements because ambulatory monitoring can provide important information not...

  • Divergent Retinal Vascular Abnormalities in Normotensive Persons and Patients With Never-Treated, Masked, White Coat Hypertension. Triantafyllou, Areti; Doumas, Michael; Anyfanti, Panagiota; Gkaliagkousi, Eugenia; Zabulis, Xenophon; Petidis, Konstantinos; Gavriilaki, Eleni; Karamaounas, Polykarpos; Gkolias, Vasileios; Pyrpasopoulou, Athina; Haidich, Anna- Bettina; Zamboulis, Chrysanthos; Douma, Stella // American Journal of Hypertension;Mar2013, Vol. 26 Issue 3, p318 

    BACKGROUND Hypertensive patients with retinal arteriolar abnormalities are at increased risk for cardiovascular events. However, the extent of retinal microvascular changes in naïve, never-treated patients with hypertension of short duration has not been established. In addition to this, the...

  • Functional capacity and heart rate response: associations with nocturnal hypertension. Ritvo, Paul; Stefanyk, Leslie E.; Azargive, Saam; Stojanovic, Slobodan; Stollon, Faye; Habot, Juda; Khaykin, Yaariv; Fair, Terry; Pirbaglou, Meysam // BMC Cardiovascular Disorders;Jul2015, Vol. 15 Issue 1, p1 

    Background: Absences of normative, 10-20 % declines in blood pressure (BP) at night, termed nocturnal non-dipping, are linked to increased cardiovascular mortality risks. Current literature has linked these absences to psychological states, hormonal imbalance, and disorders involving...

  • PRACTICAL ASPECTS OF HOME AND AMBULATORY BLOOD PRESSURE MONITORING. Peixoto, Aldo J. // Methodist DeBakey Cardiovascular Journal;Oct2015, Vol. 11 Issue 4, p214 

    Out-of-office blood pressure (BP) monitoring is becoming increasingly important in the diagnosis and management of hypertension. Home BP and ambulatory BP monitoring (ABPM) are the two forms of monitoring BP in the out-of-office environment. Home BP monitoring is easy to perform, inexpensive,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics