Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors

Chan Joo Yeom; Yoko Goto; Yuxi Zhu; Hiraoka, Masahiro; Harada, Hiroshi
November 2012
International Journal of Molecular Sciences;Nov2012, Vol. 13 Issue 11, p13949
Academic Journal
Because of the accelerated proliferation of cancer cells and the limited distance that molecular oxygen can diffuse from functional tumor blood vessels, there appears to be a unique histology in malignant solid tumors, conglomerates of micro tumor cords. A functional blood vessel exists at the center of each tumor cord and is sequentially surrounded by well-oxygenated, oxygen-insufficient, and oxygen-depleted cancer cells in the shape of baumkuchen (layered). Cancer cells, by inducing the expression of various genes, adapt to the highly heterogeneous microenvironments in each layer. Accumulated evidence has suggested that not only tumor microenvironments but also cellular adaptive responses to them, influence the radioresistance of cancer cells. However, precisely how these factors affect one another and eventually influence the therapeutic effect of radiation therapy remains to be elucidated. Here, based on recent basic and clinical cancer research, we deduced extrinsic (oxygen concentration, glucose concentration, pH etc.) and intrinsic (transcriptional activity of hypoxia-inducible factor 1, metabolic pathways, cell cycle status, proliferative activity etc.) parameters in each layer of a tumor cord. In addition, we reviewed the latest information about the molecular mechanism linking these factors with both tumor radioresistance and tumor recurrence after radiation therapy.


Related Articles

  • Overexpression of Eag1 potassium channels in clinical tumours. Hemmerlein, Bernhard; Weseloh, Rüdiger M.; Queiroz, Fernanda Mello de; Knötgen, Hendrik; Sánchez, Araceli; Rubio, María E.; Martin, Sabine; Schliephacke, Tessa; Jenke, Marc; Heinz-Joachim-Radzun; Stühmer, Walter; Pardo, Luis A. // Molecular Cancer;2006, Vol. 5, p41 

    Background: Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a large range of normal and tumour tissues from different collections...

  • Inhibiting Effects of a Cyclic Peptide CNGRC on Proliferation and Migration of Tumor Cells In Vitro. Wei, Yan; Yin, Guangfu; Yin, Hao; Yan, Danhong; Ma, Chuying; Huang, Zhongbing; Liao, Xiaoming; Yao, Yadong; Chen, Xianchun // International Journal of Peptide Research & Therapeutics;Jun2013, Vol. 19 Issue 2, p163 

    The cyclic peptide Cys-Asn-Gly-Arg-Cys (CNGRC) has previously been demonstrated as a tumor vasculature-homing peptide, which can specifically bind to CD13/aminopeptidase N in vivo. However, the effect of the peptide (CNGRC) binding to tumor cells in vitro has not yet been reported. In this...

  • LEGUME MOLECULE MAY FIGHT CANCER.  // New Vegetarian & Natural Health;Winter2006, p10 

    The article cites a research conducted by Peter Greshoff of the University of Queensland in Brisbane, Queensland which found a molecule in legumes that is capable of cutting blood supply to tumors. By cutting blood supply to tumors, growth and regression of cancer can be prevented. Greshoff's...

  • Driving glioblastoma growth by alternative polyadenylation. Han, Ting; Kim, John K // Cell Research;Sep2014, Vol. 24 Issue 9, p1023 

    Global shortening of 3′ untranslated regions (3′ UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3′ UTR shortening in glioblastomas and demonstrates a causal...

  • Semi-automated evaluation of Ki-67 index in invasive ductal carcinoma of the breast. SUCIU, CRISTIAN; MURESAN, ANCA; CORNEA, REMUS; SUCIU, OANA; DEMA, ALIS; RAICA, MARIUS // Oncology Letters;2014, Vol. 7 Issue 1, p107 

    A significant factor that affects the value of the Ki-67 proliferation index (IK) is the interpretation and implementation approach. This method is based on visual or automated methods to count tumor nuclei labeled with Ki-67 antigen, and is prone to errors. Detection of Ki-67 is a useful tool...

  • Fish and Breast Cancer. Hampton, Tracy // JAMA: Journal of the American Medical Association;12/5/2007, Vol. 298 Issue 21, p2474 

    This article reports on a study using zebrafish to understand how human cancer cells invade tissues and form new blood vessels. The study has shown how 2 proteins in the metastasis of malignant cancer cells in breast cancer work to allow breast cancer cells to enter blood vessels and thus travel...

  • CD133+ Glioblastoma Stem-Like Cells Induce Vascular Mimicry in Vivo. Ming-Tsang Chiao; Yi-Chin Yang; Wen-Yu Cheng; Chiung-Chyi Shen; Jiunn-Liang Ko // Current Neurovascular Research;Aug2011, Vol. 8 Issue 3, p210 

    Glioblastoma is one of the most angiogenic malignancies, the neoplastic vessels of which are likely to arise by angiogenesis and vasculogenesis. An alternative mechanism of tumor vasculature is described, termed vasculogenic mimicry, by which highly aggressive tumor cells can form vessel-like...

  • Multiscale modelling and nonlinear simulation of vascular tumour growth. Macklin, Paul; McDougall, Steven; Anderson, Alexander; Chaplain, Mark; Cristini, Vittorio; Lowengrub, John // Journal of Mathematical Biology;Apr2009, Vol. 58 Issue 4/5, p765 

    In this article, we present a new multiscale mathematical model for solid tumour growth which couples an improved model of tumour invasion with a model of tumour-induced angiogenesis. We perform nonlinear simulations of the ulti-scale model that demonstrate the importance of the coupling between...

  • Tenascin-C is expressed by human glioma in vivo and shows a strong association with tumor blood vessels. Brösicke, Nicole; Landeghem, Frank; Scheffler, Björn; Faissner, Andreas // Cell & Tissue Research;Nov2013, Vol. 354 Issue 2, p409 

    The extracellular matrix (ECM) protein tenascin-C (TN-C) is upregulated within glioma tissues and cultured glioma cell lines. TN-C possesses a multi-modular structure and a variety of functional properties have been reported for its domains. We describe five novel monoclonal antibodies...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics