Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes

Kim, Tae; Park, Man; Lee, Seong; Yang, Sae; Lee, Kwan; Nam, Moon; Park, Yong; Woo, Jeong; Kim, Young; Baik, Sei
December 2012
Endocrine (1355008X);Dec2012, Vol. 42 Issue 3, p584
Academic Journal
The purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes. This cross-sectional study recruited subjects from the pre-diabetic cohort of the Korea National Diabetes Program. Among study subjects ( n = 616) aged 21-77 years with a history of hyperglycemia (fasting plasma glucose (FPG) ≥5.5 mmol/mL), analyses were conducted on 504 participants (296 women, 208 men) except for subjects with FPG ≥ 7.0 mmol/L or 120-min post-challenge plasma glucose ≥11.1 mmol/L or A1C ≥ 6.5 %. For insulin sensitivity and β-cell function classified by the categories of A1C levels, ∆Ins/∆Glu was lower in the highest quartile group than other groups. Although there was no significant difference in HOMA-IR according to the A1C categories, even lowest A1C group (≤5.3 %) already included many subjects with abnormal glucose tolerance. A1C showed a significant association with hsCRP, number of metabolic syndrome (MetS) components and ∆Ins/∆Glu after adjusting for age, gender, BMI, and medications whereas HOMA-IR was insignificantly associated with A1C. Stepwise regression analysis for A1C showed that A1C is independently and negatively associated with ∆Ins/∆Glu, and positively associated with hsCRP. Our study showed that higher A1C was associated with impaired early-phase insulin secretion, MetS, and low grade inflammation in Koreans with the relatively high risk for the future development of diabetes.


Related Articles

  • Association between Serum 25-Hydroxyvitamin D Level and Insulin Resistance in a Rural Population. Bo Mi Song; Hyeon Chang Kim; Dong Phil Choi; Sun Min Oh; Il Suh // Yonsei Medical Journal;Jul2014, Vol. 55 Issue 4, p1036 

    Purpose: A low serum 25-hydroxyvitamin D [25(OH)D] level in the blood has been correlated with an increased risk of diabetes mellitus; however, the association be-tween serum 25(OH)D level and insulin resistance has not been established in a Korean rural population. The aim of this study was to...

  • Differentiation of obese patients at moderate or higher Findrisc score based on their atherogenic index. Andreeva-Gateva, Pavlina A.; Konsulova, Petya; Orbetzova, Maria; Georgieva-Nikolova, Radka; Tafradjiiska-Hadjiolova, Radka; Angelova, Violina; Voynikov, Yulian; Nikolova, Irina; Simova, Iscra // Postgraduate Medicine;Nov2016, Vol. 128 Issue 8, p790 

    Objectives: The purpose of this study was to reveal different subgroups of patients with at least moderate risk of developing diabetes in the next 10 years, based on clustering of cardiovascular risk factors.Methods: We performed a one-center cross-sectional study of...

  • Risk Factors Associated with Metabolic Syndrome in Iranian Middle Aged Women. Delavar, Mouloud Agajani; Lye, Munn Sann; Khor, Geok Lin; Syed Hassan, Syed Tajuddin B; Hanachi, Parichehr // HealthMed;2011, Vol. 5 Issue 6, p1522 

    Background: Metabolic syndrome, which is linked to increased risk of diabetes and cardiovascular disease, is increasing in Iran due to rapid nutrition transition and the nature of obesity epidemic. Objective: The aimed of the study was to examine risk factors contributing to the development of...

  • Risk for Obstructive Sleep Apnea among People with Diabetes. Nasser, Jameel; Habib, Fatima; Malallah, Fatima; Darwish, Nada; Rabie, Ebtisam // Bahrain Medical Bulletin;Sep2014, Vol. 36 Issue 3, p1 

    Objective: The aim of this study is to identify people at high risk for Obstructive Sleep Apnea (OSA) and to evaluate the impact of OSA on the control of cardiovascular risk factors. Design: A Cross-Sectional Study. Setting: Four Primary Health Care Centers. Method: Patients attending diabetes...

  • Link has been found between wrist size and risk of diabetes.  // Podiatry Now;Jun2011, Vol. 14 Issue 6, p14 

    The article reports a study published in the journal "Circulation" which identified an association between wrist circumference and a risk for diabetes and heart disease in overweight children.

  • Metabolic syndrome in an adolescent -- case report. Paul, Corina; Velea, I.; Tamasan, Ionela // Romanian Journal of Pediatrics;2011, Vol. 60 Issue 3, p284 

    The metabolic syndrome (MS) represents a sum of risk factors leading to the occurence of cardio-vascular diseases and diabetes mellitus (DM). Of these factors we can mention: abdominal obesity, dyslipidemia, arterial hypertension, impaired glucose tolerance. That is why the early depistation of...

  • Should Physical Activity Recommendations Be Ethnicity-Specific? Evidence from a Cross-Sectional Study of South Asian and European Men. Celis-Morales, Carlos A.; Ghouri, Nazim; Bailey, Mark E. S.; Sattar, Naveed; Gill, Jason M. R. // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    Background: Expert bodies and health organisations recommend that adults undertake at least 150 min.week−1 of moderate-intensity physical activity (MPA). However, the underpinning data largely emanate from studies of populations of European descent. It is unclear whether this level of...

  • The association of cardiovascular risk factors with saturated fatty acids and fatty acid desaturase indices in erythrocyte in middle-aged Korean adults. Seung Rye Kim; So Yeon Jeon; Seung-Min Lee // Lipids in Health & Disease;10/24/2015, Vol. 14, p1 

    Background: The quality of dietary fats is associated with risk of cardiovascular diseases (CVD). We aimed to investigate the association between fatty acids in erythrocyte membrane phospholipids and CVD risk factors in middle-aged Korean adults. Methods: Fifty-five middle-aged adults who...

  • Association of Magnesium Intake with High Blood Pressure in Korean Adults: Korea National Health and Nutrition Examination Survey 2007–2009. Choi, Mi-Kyeong; Bae, Yun Jung // PLoS ONE;Jun2015, Vol. 10 Issue 6, p1 

    Background: Magnesium is known to lower the risk of cardiovascular disease. However, studies on its relationship with hypertension, a single and common cause of various chronic diseases, are limited and their findings are not consistent. The purpose of the present study is to identify the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics