Diagnostic value of antithyroid peroxidase antibody for incidental autoimmune thyroiditis based on histopathologic results

Rho, Myung; Kim, Dong; Hong, Hyun; Park, Young; Kwon, Min; Jung, Soo; Kim, Young; Kang, Taewoo
December 2012
Endocrine (1355008X);Dec2012, Vol. 42 Issue 3, p647
Academic Journal
Detection of antithyroid peroxidase antibody (TPOAb) is widely used in the diagnosis of autoimmune thyroiditis (AIT), but no research has evaluated the diagnostic accuracy of TPOAb detection using histopathologic reference standards. To fill this research gap, this study assessed the diagnostic accuracy of detection of TPOAb and that of other serological markers in asymptomatic patients who had been diagnosed with AIT by histopathologic analysis after thyroid surgery. After review of patient records, 598 patients who had undergone thyroid nodule surgery were enrolled for examination for thyroid parenchyma by a pathologist and classification into no co-existing lymphocytic thyroiditis, Hashimoto thyroiditis, or non-Hashimoto type of lymphocytic thyroiditis (NHLT). The correlation between patient serological data and thyroid parenchyma pathology was analyzed. Statistically significant differences ( P < 0.05) were found between co-existing lymphocytic thyroiditis and no co-existing lymphocytic thyroiditis groups regarding thyroid-stimulating hormone (TSH) and TPOAb levels. And, TPOAb titer was significantly associated with the degree of inflammation. An abnormal TPOAb titer was found in 86 of the 598 patients (14.4 %) and the specificity of TPOAb detection for AIT diagnosis was found to be 96.9 %. The prevalence of Hashimoto thyroiditis and NHLT in the 560 papillary thyroid cancer (PTC) patients was found to be 7.9 and 17.9 %, respectively. The results indicate that TPOAb titer is associated with the degree of thyroid inflammation and that detection of TPOAb is a very specific means of diagnosing AIT. The results also indicate that the incidence of AIT and PTC coexistence is relatively high.


Related Articles

  • Unusual presentations of Hashimoto's encephalopathy: trigeminal neuralgiaform headache, skew deviation, hypomania. Beckmann, Yesim; Top, Dilek; Yiğit, Tamer // Endocrine (1355008X);Dec2011, Vol. 40 Issue 3, p495 

    Hashimoto's encephalopathy (HE) is a term used to describe an encephalopathy of presumed autoimmune origin characterized by high titers of antithyroid-peroxidase antibodies. We describe three patients showing unusual clinical presentations like trigeminal-neuralgia, skew deviation, hypomania...

  • A possible case of Hashimoto's encephalopathy after surgery and radiometabolic therapy for thyroid carcinoma. Onesti, Emanuela; Koudriavtseva, Tatiana; Galiè, Edvina; Anelli, Vincenzo; Jandolo, Bruno // Neurological Sciences;Aug2013, Vol. 34 Issue 8, p1489 

    No abstract available.

  • Selenium and the thyroid: A close-knit connection. Bhuyan, Ashok K.; Sarma, Dipti; Saikia, Uma K. // Indian Journal of Endocrinology & Metabolism;Dec2012 Supplement, Vol. 16, pS354 

    Introduction: In areas with severe selenium deficiency higher incidence of thyroiditis has been reported due to a decreased activity of selenium-dependent glutathione peroxidase enzyme within thyroid cells. Aims and Objective: To study the effect of selenium supplementation in patients with...

  • Analiza komórek CD4+CD161+CD196+ i CD4+IL-17+ Th17 we krwi obwodowej u mÅ‚odocianych z zapaleniem tarczycy typu Hashimoto i chorobÄ… Gravesa-Basedowa. Bossowski, Artur; Moniuszko, Marcin; Idźkowska, Ewelina; Dąbrowska, Milena; Jeznach, Marta; Sawicka, Beata; Borysewicz-Sańczyk1, Hanna; Bossowska, Anna; Rusak, Małgorzata; Bodzenta-Łukaszyk, Anna // Pediatric Endocrinology, Diabetes & Metabolism;2012, Vol. 18 Issue 3, p89 

    Introduction: Up till now, altered balance of Th1 and Th2 immune cells has been postulated to play an important role in the pathogenesis of autoimmune thyroid diseases (AITD). However, recent studies on thyroid diseases suggest a new role for Th17 (T helper 17) cells that have been classified as...

  • Rheumatic manifestations of euthyroid, anti-thyroid antibody-positive patients. Tagoe, Clement; Zezon, Anna; Khattri, Saakshi; Castellanos, Patricia // Rheumatology International;Jul2013, Vol. 33 Issue 7, p1745 

    The aim of this study is to define the rheumatic manifestations of euthyroid patients with chronic lymphocytic thyroiditis (CLT) but without a well-defined connective tissue disease. Forty-six consecutive patients with anti-thyroid peroxidase (αTPO) and/or anti-thyroglobulin antibodies...

  • What is the benefit of screening for thyroid function in pregnant women in the detection of newly diagnosed thyropathies? Sarapatkova, Hana; Sarapatka, Jan; Frysak, Zdenek // Biomedical Papers of the Medical Faculty of Palacky University i;Dec2013, Vol. 157 Issue 4, p358 

    Background. Thyroid gland disturbances are the most common endocrine disorders in pregnancy. There are some particular recommendations for the investigation of women in risk groups, but no consensus guidelines for general screening exists at present in the Czech Republic. Aim. The aim of our...

  • Seronegative Hashimoto thyroiditis with thyroid autoantibody production localized to the thyroid. Baker Jr., Maj James R.; Saunders, Nancy B.; Wartofsky, Col Loenard; Tseng, Yueh-Chu L.; Burman, Col Kenneth D.; Baker, J R Jr; Saunders, N B; Wartofsky, L; Tseng, Y C; Burman, K D // Annals of Internal Medicine;Jan88, Vol. 108 Issue 1, p26 

    A patient without serologic evidence of an autoimmune disorder had a thyroidectomy for neck compression caused by her goiter. Histologic examination of the gland revealed pathologic changes compatible with Hashimoto disease, and lymphocytes isolated from her thyroid gland were transformed into...

  • Evidence for Higher Success Rates and Successful Treatment Earlier in Graves' Disease with Higher Radioactive Iodine Doses. Sztal-Mazer, Shoshana; Nakatani, Viviane Yumi; Bortolini, Luis Gustavo; Boguszewski, Cesar Luiz; Graf, Hans; de Carvalho, Gisah Amaral // Thyroid;Oct2012, Vol. 22 Issue 10, p991 

    Background: Graves' disease is commonly treated with curative intent using radioactive iodine (RAI). While higher doses have been shown to increase success rates, more evidence is needed. Further, very few studies assess the time to treatment success without the need for antithyroid drugs after...

  • Metamorphic thyroid autoimmunity in Down Syndrome: from Hashimoto's thyroiditis to Graves' disease and beyond. Aversa, Tommaso; Valenzise, Mariella; Salerno, Mariacarolina; Corrias, Andrea; Iughetti, Lorenzo; Radetti, Giorgio; De Luca, Filippo; Wasniewska, Malgorzata // Italian Journal of Pediatrics;11/11/2015, Vol. 14, p1 

    Background: It is known that Hashimoto's thyroiditis (HT) may progress to Graves' disease (GD) and that this phenomenon may be more frequent in the patients with Down syndrome (DS). Aims: To shed light on the relationships between Down syndrome (DS) and metamorphic thyroid autoimmunity. Patients...


Read the Article

Courtesy of

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics