TITLE

Resolution of immune response by recombinant transforming growth factor-beta (rTGF-β) during influenza A virus infection

AUTHOR(S)
Srivastava, Vikram; Khanna, Madhu; Sharma, Sonal; Kumar, Binod
PUB. DATE
October 2012
SOURCE
Indian Journal of Medical Research;Oct2012, Vol. 136 Issue 4, p641
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background & objectives: Replication of influenza A virus in the respiratory tract leads to cell damage and liberation of cytokines and chemokines. The in vivo cytokine induction and modulation by recombinant transforming growth factor- β1 (rTGF-β1) has not been studied. Therefore, in the present study the effect of rTGF-β1, a potent immunomodulatory cytokine which has anti-inflammatory properties and downregulates the release of inflammatory molecules, against influenza-virus infection in the airway of mice was investigated. Methods: rTGF-β1 was administered intravenously to mice with concomitant intranasal infection of influenza A/Udorn/317/72 (H3N2) virus, and the survival rate, virus titre, histopathological changes and levels of factors regulating inflammation in the airway fluid were analysed. Result: The immune response to influenza A virus was characterized by an influx of both macrophages and lymphocytes into the lungs of the infected host. rTGF-β1 significantly suppressed virus multiplication and improved the survival rate of mice. rTGF-β1 downregulated infiltration of neutrophils and the release of inflammatory molecules, such as interferon-gamma (IFN-γ), interleukin-1 β (IL-1β) and stimulated release of IL-10 that potentiates anti-inflammatory response into airway. Interpretation & conclusions: A generalized pulmonary inflammation does not contribute to viral clearance but represents an immunological background within which antiviral immunity operates. Treatment with rTGF-β1 reduced macrophage count and neutrophils influx in lungs of infected mice.
ACCESSION #
83699288

 

Related Articles

  • Transforming Growth Factor-Beta and the Kidney: What We Know and What We Can Do? Hai-Chun Yang; Yiqin Zuo; Fogo, Agnes B. // Current Enzyme Inhibition;Jul2010, Vol. 6 Issue 2, p87 

    Transforming growth factor-� (TGF-�) and its receptors are expressed in the kidney. The effects of TGF-� are mainly through activation of Smad pathways. In different pathophysiological situations such as development, immunomodulation, fibrosis and cell response, TGF-�...

  • Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response Machado, Paulo R.; Rosa, Maria Elisa A.; Costa, Diego; Mignac, Moema; Silva, João S.; Schriefer, Albert; Teixeira, Mauro M.; Bacellar, Olivia; Carvalho, Edgar M. // Transactions of the Royal Society of Tropical Medicine & Hygiene;Aug2011, Vol. 105 Issue 8, p438 

    Abstract: Disseminated leishmaniasis (DL) is an emerging form of Leishmania braziliensis infection characterised by multiple cutaneous lesions on different parts of the body and a high rate of mucosal involvement. Systemic production of TNFα and IFNγ in DL patients is lower than in...

  • TGF-β and Regulatory T Cell in Immunity and Autoimmunity. Yisong Wan // Journal of Clinical Immunology;Nov2008, Vol. 28 Issue 6, p647 

    Abstract Introduction  The immune response is controlled by several inhibitory mechanisms. These mechanisms include regulatory T cells, which exist in multiple classes. Notable among these are Foxp3-expressing regulatory T cells (Treg), NKT cells, and Tr1 cells. Common to these...

  • TUMOUR IMMUNOLOGY: Dealing with tumours. Bell, Elaine // Nature Reviews Immunology;Nov2001, Vol. 1 Issue 2, p87 

    Reports on the results of a study on the suppression of anti-tumor immune responses. Functions of the transforming growth factor-β cytokine; Requirements for effective tumor eradication; Implications for cancer therapy.

  • Transforming Growth Factor � (TGF-�) and Regulatory T Cells (Treg): The Interface of Tumor and Host Immunity. Maeda Oda, Julie Massayo; Guembarovski, Roberta Losi; Ehara Watanabe, Maria Angelica // European Neurological Journal;Mar2012, Vol. 4 Issue 1, p27 

    Signals from the microenviroment have a profound influence on the maintenance or progression of cancers. It is known that the transforming growth factor beta (TGF-�) can act as both a tumor suppressor and as a significant stimulator of tumor progression, invasion, and metastasis. TGF-�...

  • The Effect of Cytokines on MicroRNA Expression in TW01 Nasopharyngeal Carcinoma Cells. Ting Wei Lee; Eng Lai Tan; Ching Ching Ng; Sook Yee Gan // British Journal of Medicine & Medical Research;Jul-Sep2013, Vol. 3 Issue 3, p543 

    Aims: To determine the effect of cytokines, namely transforming growth factor-beta one (TGF-β1), and interleukin-6 (IL-6) on the expression of 88 cancer-related microRNAs (miRNAs) in TW01 nasopharyngeal carcinoma (NPC) cells with or without the presence of Epstein-Barr virus latent membrane...

  • Transforming Growth Factor-β1 Regulates the Expression of the High-Affinity Receptor for IgE on CD34+ Stem Cell-Derived CD1a+ Dendritic CellsIn Vitro. Allam, Jean-Pierre; Klein, Elisabeth; Bieber, Thomas; Novak, Natalija // Journal of Investigative Dermatology;Oct2004, Vol. 123 Issue 4, p676 

    It has been reported that monocytes, Langerhans cells (LC) and other dendritic cells (DC) express the high-affinity receptor for IgE (FcℇRI) in patients with atopic diseases. These cells may be instrumental in the control of the immune response and the allergic inflammation. In this...

  • Seminal plasma and male factor signalling in the female reproductive tract. Robertson, Sarah A. // Cell & Tissue Research;Oct2005, Vol. 322 Issue 1, p43 

    In mammals, insemination results in the transmission of seminal factors that act, in the female reproductive tract, to promote sperm survival, to “condition” the female immune response to tolerate the conceptus and to organise molecular and cellular changes in the endometrium to...

  • Reduced Lung Function in a Chronic Asthma Model Is Associated with Prolonged Inflammation, but Independent of Peribronchial Fibrosis. Koerner-Rettberg, Cordula; Doths, Sandra; Stroet, Anke; Schwarze, Jürgen // PLoS ONE;2008, Vol. 3 Issue 2, p1 

    Background: In asthma, mechanisms contributing to chronicity remain to be determined. Recent models of sensitisation with prolonged airway allergen challenges reproduce typical features of chronic asthma. However, the interplay between inflammation, structural changes and lung function is poorly...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics