Virologic and Immunologic Evidence Supporting an Association between HHV-6 and Hashimoto's Thyroiditis

Caselli, Elisabetta; Zatelli, Maria Chiara; Rizzo, Roberta; Benedetti, Sabrina; Martorelli, Debora; Trasforini, Giorgio; Cassai, Enzo; degli Uberti, Ettore C.; Di Luca, Dario; Dolcetti, Riccardo
October 2012
PLoS Pathogens;Oct2012, Vol. 8 Issue 10, Special section p1
Academic Journal
Hashimoto's thyroiditis (HT) is the most common of all thyroid diseases and is characterized by abundant lymphocyte infiltrate and thyroid impairment, caused by various cell- and antibody-mediated immune processes. Viral infections have been suggested as possible environmental triggers, but conclusive data are not available. We analyzed the presence and transcriptional state of human herpesvirus 6 (HHV-6) in thyroid fine needle aspirates (FNA) and peripheral blood mononuclear cells (PBMCs) from 34 HT patients and 28 controls, showing that HHV-6 DNA prevalence (82% vs. 10%, p≤0.001) and viral load were significantly increased in FNA from HT patients, and thyrocytes from HT FNA displayed a 100-fold higher HHV-6 DNA load compared to infiltrating lymphocytes. In addition, while HHV-6 was strictly latent in positive samples from controls, a low grade acute infection was detected in HT samples. HHV-6 variant characterization was carried out in 10 HT FNA samples, determining that all specimens harbored HHV-6 Variant A. The tropism of HHV-6 for thyroid cells was verified by infection of Nthy-ori3-1, a thyroid follicular epithelial cell line, showing that thyrocytes are permissive to HHV-6 replication, which induces de novo expression of HLA class II antigens. Furthermore, HHV-6-infected Nthy-ori3-1 cells become targets for NK-mediated killing, NK cells from HT patients show a significantly more efficient killing of HHV-6 infected thyroid cells than healthy controls, and HT patients have increased T-cell responses to HHV-6 U94 protein, associated to viral latency. These observations suggest a potential role for HHV-6 (possibly variant A) in the development or triggering of HT.


Related Articles

  • Chemokines as Novel Therapeutic Targets in Autoimmune Thyroiditis. Fang, Yujiang; Zhao, Lei; Yan, Feng // Recent Patents on DNA & Gene Sequences;Jan2010, Vol. 4 Issue 1, p52 

    Chemokines, a group of proinflammatory chemotactic cytokines, function to recruit leukocytes to inflammation sites, but they also play important roles in tumor growth, angiogenesis, organ sclerosis, and autoimmunity. In recent years, increasing evidence has accumulated to support the concept...

  • Association of immunoblastic lymphadenopathy and Hashimoto's thyroiditis. Watanabe, Hiroko; Watanabe, H // Annals of Internal Medicine;Jul77, Vol. 87 Issue 1, p62 

    A 75-year-old white woman with a supraclavicular mass and primary hypothyroidism was found to have immunoblastic lymphadenopathy and Hashimoto's thyroidits. Peripheral blood contained normal percentages of T and B lymphocytes, but there was a markedly decreased response to phytohemagglutinin and...

  • Modulation of Apoptosis: New Opportunities for Drug Discovery to Treat Autoimmune Thyroiditis. Fang, Yujiang; Zhao, Lei; Parker, Charles A.; Yan, Feng; Zhang, Chunwei // Recent Patents on Inflammation & Allergy Drug Discovery;Nov2010, Vol. 4 Issue 3, p255 

    The balance between apoptosis and cell proliferation is the key determinant in the pathogenesis of many diseases including autoimmune thyroiditis. In recent years, many studies have strengthened the concept that pro-and antiapoptotic molecules expressed in thyroid epithelial cells as well as in...

  • Intermittent ophthalmoplegia.  // British Medical Journal;12/2/1978, Vol. 2 Issue 6151, p1534 

    Presents a case report on Hashimoto thyroiditis in Great Britain. Signs and symptoms; Complications of the disease; Increased level of triiodothyronine than thyroxine secretions.

  • Variation in Rates of Autoimmune Thyroid Disease by Race/Ethnicity in US Military Personnel. McLeod, Donald S. A.; Caturegli, Patrizio; Cooper, David S.; Matos, Peter G.; Hutfless, Susan // JAMA: Journal of the American Medical Association;4/16/2014, Vol. 311 Issue 15, p1563 

    A letter to the editor is presented in response to an article about the correlation between autoimmune thyroid disease and race/ethnicity among U.S. military personnel, that was published in a 2014 issue of the "Journal of American Medical Association" (JAMA).

  • Autoimmune Thyroid Diseases in a Large Group of Hungarian Patients with Primary Sjögren's Syndrome. Margit Zeher; Ildiko Fanny Horvath; Antonia Szanto; Peter Szodoray // Thyroid;Jan2009, Vol. 19 Issue 1, p39 

    Background:Previous studies on relatively small populations of patients with primary Sjögren's syndrome (pSS) suggested an association between pSS and Hashimoto's thyroiditis (HT). As some findings in the literature regarding the relationship between pSS and thyroid disease are contradictory,...

  • Papillary thyroid cancer significantly linked to autoimmune disease. Adams, Stacey L.; Leiser, Mark; Shafer, Emily; Taliercio, Adam; Volansky, Rob // Hem/Onc Today;4/25/2013, Vol. 14 Issue 8, p44 

    The article discusses the results of a study which showed a link between papillary thyroid cancer (PTC) and pathologically confirmed Hashimoto's thyroiditis, an autoimmune disease.

  • Thyroid Peroxidase Antibodies. Sadler, Chris // Clinician Reviews;Dec2015 Supplement Celebrating with NPs & PAs, pS16 

    The article provides an answer to a question regarding treatment of a patient suffering from Thy­roid peroxidase (TPO) antibod­ies.

  • Celiac autoimmunity in autoimmune thyroid disease is highly prevalent with a questionable impact. Sharma, Bharat Rakeshkumar; Joshi, Ameya S.; Varthakavi, Premlata K.; Chadha, Manoj D.; Bhagwat, Nikhil M.; Pawal, Pratibha S. // Indian Journal of Endocrinology & Metabolism;Jan/Feb2016, Vol. 20 Issue 1, p97 

    Introduction: The prevalence of autoimmune thyroid disease (AITD) is 10-12% in the general population worldwide. Among various disorders co-existing with AITD, the concomitance of celiac disease (CD) with AITD results in poor absorption of thyroid medications and results in higher doses of the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics