Redefining Chronic Toxoplasmosis--A T Cell Exhaustion Perspective

Bhadra, Rajarshi; Khan, Imtiaz A.
October 2012
PLoS Pathogens;Oct2012, Vol. 8 Issue 10, Special section p1
Academic Journal
The article discusses CD8 T cells exhaustion during chronic toxoplasmosis and its implication for immunotherapy against Toxoplasma gondii protozoa. Based on observation, HIV-infected nonprogressors is controlled by virus-specific polyfunctional CD8 T cell response and development of memory phenotype CD44 and CD127. A study is cited which explored the positive costimulatory signals CD40-CD40L pathway during the rescue of exhausted C8 T cells.


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