TITLE

FORMULATION AND EVALUATION OF FLOATING TABLETS OF OFLOXACIN

AUTHOR(S)
S., Saigeethika; Singhvi, Gautam; Ramanjaneyulu
PUB. DATE
November 2012
SOURCE
International Journal of Pharmaceutical Sciences & Research;Nov2012, Vol. 3 Issue 11, p4291
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone. Gastric emptying of dosage forms is an extremely variable process and ability to prolong and control the emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Several difficulties are faced in designing controlled release systems for better absorption and enhanced bioavailability. To overcome the problem of conventional dosageforms ofloxacin effervescent floating tablets were developed in six different formulations (F1 to F6) by employing different grades of polymers and effervescent agent sodium bicarbonate. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution parameters and drug release mechanisms. F6 formulation showed good physical parameters and gave slow and maximum drug release of ofloxacin spread over 24 hours and showed maximum similarity with marketed product in dissolution profile. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics.
ACCESSION #
83412887

 

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