TITLE

Noninvasive Diagnosis of NASH and Liver Fibrosis Within the Spectrum of NAFLD

AUTHOR(S)
Alkhouri, Naim; McCullough, Arthur J.
PUB. DATE
October 2012
SOURCE
Gastroenterology & Hepatology;Oct2012, Vol. 8 Issue 10, p661
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in the United States, affecting an estimated 70 million Americans. The histologic spectrum of NAFLD ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and eventually cirrhosis. Patients with NASH and significant fibrosis seen on liver biopsy have an increased risk for liver-related morbidity and mortality compared to patients with simple steatosis. Due to the high prevalence of NAFLD, there has been an urgent need to develop reliable noninvasive markers and tests that can accurately predict the presence of advanced disease without the need for liver biopsy. These tests can be divided into 2 groups: those that predict the presence of NASH (such as markers of hepatocyte apoptosis, oxidative stress, and inflammation, as well as predictive models based on clinical variables) and those that predict the presence of fibrosis (such as simple and complex predictive models). This paper provides an overview of various noninvasive methods for detecting NAFLD and suggests a diagnostic algorithm that can be used in clinical practice.
ACCESSION #
83324460

 

Related Articles

  • Pathogenesis of cBFL in common with IPF? Correlation of IP-1OIFARC ratio with histological patterns. Kishi, M.; Miyazaki, Y.; Jinta, T.; Furusawa, H.; Ohtani, Y.; Inase, N.; Yoshizawa, Y. // Thorax;Sep2008, Vol. 63 Issue 9, p810 

    Background: A Th1 predominant immune response has been shown in acute hypersensitivity pneumonitis. Predominance of Th2 appears to favour the development of pulmonary fibrosis through the profibrotic process and has been described as crucial in the progression of idiopathic pulmonary fibrosis....

  • Oral Hobnail Hemangioma: A Case Report. Hiremath, Santhosh Kumar S.; Charantimath, Shivayogi; Byakodi, Sanjay; Bijjal, Shridevi; Byakodi, Raghavendra; Sapra, Gaurav // Archives of Iranian Medicine (AIM);Jul2013, Vol. 16 Issue 7, p428 

    Hobnail hemangioma is a benign vascular lesion and intraoral of the lesions are relatively rare. Histopathologically, it shows distinctive biphasic pattern with vascular channels lined by endothelial cells showing characteristic "hobnail" cytomorphology. Since hobnail hemangioma shares similar...

  • Serum TGF-β, Serum MMP-1, and HOMA-IR as Non-Invasive Predictors of Fibrosis in Egyptian Patients with NAFLD. Mahmoud, Adel A.; Bakir, Amal S.; Shabana, Sherif S. // Saudi Journal of Gastroenterology;Sep/Oct2012, Vol. 18 Issue 5, p327 

    Background/Aim: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent cause of chronic liver disease worldwide. A number of these patients progress to nonalcoholic steatohepatitis (NASH) which carries significant morbidity and mortality. The aim of this study is to evaluate the...

  • Serum progranulin as an independent marker of liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease. Yilmaz, Yusuf; Eren, Fatih; Yonal, Oya; Polat, Zulfikar; Bacha, Mohammad; Kurt, Ramazan; Ozturk, Oguzhan; Avsar, Erol // Disease Markers;2011, Vol. 31 Issue 4, p205 

    Background: Elevated progranulin levels are associated with visceral obesity, elevated plasma glucose, and dyslipidemia. Progranulin has not been previously investigated as a biomarker of nonalcoholic fatty liver disease (NAFLD). We sought to determine whether serum progranulin levels are...

  • The Relationship of Serum Hemojuvelin and Hepcidin Levels with Iron Overload in Nonalcoholic Fatty Liver Disease. Boga, Salih; Alkim, Huseyin; Alkim, Canan; Koksal, Ali Riza; Bayram, Mehmet; Yilmaz Ozguven, Muveddet Banu; Tekin Neijmann, Sebnem // Journal of Gastrointestinal & Liver Diseases;Sep2015, Vol. 24 Issue 3, p293 

    Background & Aims: Mild iron overload is frequently reported in patients with nonalcoholic fatty liver disease (NAFLD). Hepcidin is the master iron-regulatory peptide and hemojuvelin (HJV) is the key regulator of iron-dependent secretion of hepcidin. The aims of this study were to evaluate serum...

  • Cytokeratin 18 as a non invasive marker in diagnosis of NASH and its usefulness in correlation with disease severity in Egyptian patients. Maher, Mohsen M.; Ibrahim, Wesam A.; Saleh, Shereen A.; Shash, Lobna; Gabal, Hoda Abou; Tarif, Mohammed; Gamal, Mohammed // Egyptian Journal of Medical Human Genetics;2015, Vol. 16 Issue 1, p41 

    Background: A simple noninvasive test that accurately distinguishes NASH from NAFL as well as determines the disease severity is urgently needed. Recently, it was found that determination of cytokeratin-18 (CK-18) fragments in the blood, predicts and correlates with histological NASH in which...

  • Recombinant adenovirus Ad-RUNrf2 reduces paraquat-induced A549 injury. Cai, Q; Lu, Z; Hong, G; Jiang, X; Wu, Z; Zheng, J; Song, Q; Chang, Z // Human & Experimental Toxicology;Nov2012, Vol. 31 Issue 11, p1102 

    The article presents a study on the reduction of paraquat-induced A549 injury by recombinant adenovirus Ad-Runrf2. The study made use of the enzyme-linked immunosorbent assay and Western blotting to observe the impact of RU486-induced Nrf2 expression on the inflammatory cytokines, apoptosis...

  • A New Participant in the Pathogenesis of Alcoholic Gastritis: Pyroptosis. Li, Gang; Zhu, Lei; Cao, Zhigang; Wang, Jing; Zhou, Fuxin; Wang, Xiuyun; Li, Xiaoguang; Nie, Gang // Cellular Physiology & Biochemistry (Karger AG);Sep2018, Vol. 49 Issue 1, p406 

    Background/Aims: Alcohol abuse exerts deleterious effects on the internal organs of the body, and alcohol-related gastritis is a common disease for which prompt treatment is essential to prevent the condition from growing worse. However, the therapeutic methods have some adverse...

  • Circulating Matrix Metalloproteinases 1, 2, 9 and Their Inhibitors TIMP-1 and TIMP-2 as Serum Markers of Liver Fibrosis in Patients With Chronic Hepatitis C: Comparison With PIIINP and Hyaluronic Acid. Leroy, Vincent; Monier, Frederique; Bottari, Serge; Trocme, Candice; Sturm, Nathalie; Hilleret, Marie-Noëlle; Morel, Francoise; Zarski, Jean-Pierre // American Journal of Gastroenterology;Feb2004, Vol. 99 Issue 2, p271 

    OBJECTIVES: Histological examination of liver biopsy is currently required in the management of patients with chronic hepatitis C. Our aim was to evaluate thediagnostic utilityof a panel of circulating markers in detecting the stage of fibrosis.METHODS: One hundred and ninety four-patients who...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics